#LeftVentricularNoncompaction hashtag - Bluesky

@genesndiseases.bsky.social

2 months ago

#PDE4DIP is identified as a driver of #LeftVentricularNoncompaction; its overexpression disrupts #cardiomyocyte polarity and energy metabolism, while knockdown restores #ATP and migration, highlighting new therapeutic targets for LVNC.

#OpenAccess: doi.org/10.1016/j.ge...

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Genes & Diseases Journal

@genesndiseases.bsky.social

9 months ago

#PDE4DIP activation plays a critical role in #LeftVentricularNoncompaction development by regulating #cellpolarity, skeleton, and energy metabolism via the Rho-ROCK pathway, thereby offering potential targets and therapeutic strategies. #medsky

#OpenAccess:

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Genes & Diseases Journal

@genesndiseases.bsky.social

9 months ago

Dysfunction of PDE4DIP contributes to LVNC development by regulating cell polarity, skeleton ec1 This study demonstrates that dysfunction of PDE4DIP contributes to the development of left ventricular non-compaction (LVNC) cardiomyopathy by disrupting cel...

This study identifies #PDE4DIP as a key player in #LeftVentricularNoncompaction development by regulating #cellpolarity, skeleton, and energy metabolism via the Rho-ROCK pathway. #LVNC

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