Use of a cell-based #mathematical model of #cardiac #electrophysiology to assess effects of #cardiomyocyte cell variability predicts reduced #gapjunction #cell coupling to amplify cardiomyocyte variability and destabilise the #heartbeat

Muscular-Vascular coupling🤠

Oxygen-sensing by #SkeletalMuscle Capillary #EndothelialCell

Acute (<1 min), Localized (sub-mm) O2 depletion at muscle surface->
Connexin 40 #GapJunction -mediated retrograde conduction to arterioles->
Vasodilation->
⬆️Local flow

#PNAS 2023
www.pnas.org/doi/10.1073/...