FDA points to liver injury with Amgen's Tavneos The FDA raises the pressure on Amgen to withdraw vasculitis drug Tavneos from the market with a report linking serious side effects to the drug.

The #FDA has ramped up the pressure on #Amgen to #withdraw #Tavneos for a rare #vasculitis condition from the market, with a report saying it has identified cases of serious #liverinjury – including deaths – among people taking the drug.

Intraperitoneal and Extraperitoneal Pringle Hepatic Hilar Occlusion in Laparoscopic Liver Resection: A Prospective Randomized Controlled Study

This randomized study demonstrates that Pringle #Hepatic hilar occlusion with a bulldog clamp in #Laparoscopic #LiverResection is safe and effective, reducing #LiverInjury and promoting faster recovery. #medsky

Full article here: doi.org/10.1007/s115...

Protective Effects of Berberine on Nonalcoholic Fatty Liver Disease in db/db Mice via AMPK/SIRT1 Pathway Activation

This study explores the hepatoprotective effects of #Berberine in #NAFLD, improving #InsulinResistance, lipid profiles, & #LiverInjury, while suppressing #OxidativeStress, #Inflammation, & #Apoptosis via activation of #AMPK/#SIRT1. #medsky

To read: doi.org/10.1007/s115...

Zhang et al. show that Sanghuang, a traditional medicinal fungus, may ameliorate #liverinjury and promote #regeneration by targeting multiple pathways including HIF-1α and MAPK signaling. doi.org/10.4103/REGE... #TraditionalChineseMedicine #NetworkPharmacology #MolecularDocking #MedSky #neuroskyence

Oral #sodiumnitrate markedly improves #MASLD- and #T2DM-like phenotypes by rebalancing #macrophages via a sialin–CtsL–Nrf2 axis, reducing #LiverInjury and metabolic #inflammation, and highlighting nitrate as a promising #MetabolicTherapy.

#CoverPage in #STTT: doi.org/10.1038/s413...

Effect of Lachnum YM156 Polyphenol on STAT3/COX-2 Signal Pathway and Gut Microbiota in Mice🐁 with N-Nitrosodiethylamine-Induced Hepatic Injury🩼🩹
www.ftb.com.hr/archives/196...
#SDG3 #polyphenol #gutmicrobiota #liverinjury #signallingpathway

Immunoglobulin G binding as a quantitative marker of hepatocellular death across acute and chronic liver injury
Albin, J. E. et al.
Paper
Details
#LiverInjury #Biomarkers #IgG

AMP just published!
"Drug-Induced Hepatitis Caused by Methylphenidate: A Case Report"

Full paper here:
www.actamedicaportuguesa.com/revista/inde...

#adolescent #ADHD #drugtherapy #liverinjury #methylphenidate #actamedicaportuguesa

Challenges and practical considerations in predicting idiosyncratic drug induced liver injury Explore the article collection: Challenges and practical considerations in predicting idiosyncratic drug induced liver injury. Published in Expert Opinion on Drug Metabolism & Toxicology.

Excited to see this new article collection, “Challenges and practical considerations in predicting idiosyncratic drug-induced liver injury (iDILI)”, in Expert Opinion on Drug Metabolism & Toxicology. Enjoy! tinyurl.com/ytcfytn7

#DrugSafety #DILI #Toxicology #LiverInjury #Pharmacovigilance

#LiverResearchers: Next week, Dr. Siddhi Jain from @pittdeptofmed.bsky.social will share her research on #LiverInjury and #LiverRegeneration! https://loom.ly/7bN2IQ8 #VirtualSeminar #ASIPwebinar #pathology #pathobiology

#LiverResearchers: Register for this virtual event on #LiverInjury and #LiverRegeneration with Dr. Siddhi Jain from @pittdeptofmed.bsky.social! https://loom.ly/7bN2IQ8 #VirtualSeminar #ASIPwebinar #pathology #pathobiology

Check out this highly cited article!

Scientists reveal that #Berberine (BBR) could reverse #NAFLD-related #liverinjury, likely by activating the AMPK/SIRT1 signaling pathway to inhibit oxidative stress, #inflammation, & apoptosis in #hepatic tissue. #medsky

Read: link.springer.com/article/10.1...

Epigenetics Update - HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury bit.ly/4kqmpTD

Wei-Chien Yuan/Fernando D. Camargo reporting in Cell Stem Cell

#Epigenetics #LiverInjury
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Perfect for cancer, immunology, and aging; epigenometech.com

Agents Included in LiverTox by Drug Class

#Medsky🧪 #pharmasky #publichealth LiverTox: Clinical & Research Information on Drug-Induced #LiverInjury @NIH

www.ncbi.nlm.nih.gov/books/NBK569...

FDA adds boxed warning to fezolinetant for rare serious liver injury The FDA has added a boxed warning for fezolinetant (VEOZAH; Astellas), highlighting the rare occurrence of serious liver injury in patients taking the menopause treatment.

🗞️New today: The FDA has added a boxed warning for #fezolinetant (VEOZAH; Astellas), highlighting the rare occurrence of serious #liverinjury in patients taking the #menopause treatment. ow.ly/r0c350UsUax #MedSky #OBGYNSky