MAFB and #CEBPA promote #urothelial growth, and their reduced expression in #hypospadias reveals a pathogenic mechanism whereby MAFB knockdown suppresses CEBPA, inhibits #Wntβcatenin signaling, arrests the #cellcycle, and induces #apoptosis.

#OpenAccess: doi.org/10.1016/j.ge...

This study shows that MAFB suppresses #Urothelial #CellGrowth by downregulating #CEBPA and inhibiting #Wnt/#β-catenin signalling, providing new insights into the #Genetic mechanisms underlying #Hypospadias. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

This new study identifies #CEBPA as a novel gene involved in the pathogenesis of #hypospadias and shows that abnormal expression of V-maf musculoaponeurotic fibrosarcoma oncogene homolog B and CEBPA affects uroepithelial growth via Wnt/β-catenin signaling. #medsky

#OpenAccess: buff.ly/V1c5F0V

On September 13, 2024, a study published in Genes & Diseases and led by researchers from the Children’s Hospital of Chongqing Medical University in China identified MAFB and CEBPA as crucial regulators of urothelial cell growth.
#Apoptosis #CEBPA
Details: doi.org/10.1016/j.ge...