an elderly woman is dancing in front of a brick wall and a trash can . ALT: an elderly woman is dancing in front of a brick wall and a trash can .

Could get used to these “accept” emails 🙃 Looks like we might finally have a double feature about #proteotoxicity #proteasome and #p-bodies #autophagy coming up soon 🤩

Very happy to share our recent preprint describing #Golgi protein quality control #PQC in mammalian cells. #proteasome #ubiquitin #ChemBio Fantastic work by @joaodiamantino.bsky.social and team! #proudPI @unidue-zmb.bsky.social @imprs-lm.bsky.social

This review highlights emerging “neurodevelopmental proteasomopathies,” #monogenic disorders linked to #proteasome variants, discussing their molecular mechanisms, and potential as #biomarkers for diagnosis and therapy. @cnrs.fr @inserm.fr

#OpenAccess: doi.org/10.1016/j.ge...

This review highlights emerging “neurodevelopmental proteasomopathies,” #monogenic disorders linked to #proteasome variants, discussing their molecular mechanisms, and potential as #biomarkers for diagnosis and therapy. @cnrs.fr @inserm.fr

#OpenAccess: doi.org/10.1016/j.ge...

Formation & function of #MembranelessOrganelles! #CryoET structures of #proteasome storage granules inside cells!
Read our paper @cp-cell.bsky.social!

❕Publication: doi.org/10.1016/j.ce...
❕Press Release: www.biochem.mpg.de/en/pressroom

@uoftmedicine.bsky.social
@erc.europa.eu #UPSmeetMet

Graphical abstract for "Proteasome-associated autoinflammatory syndromes: The impact of mutations in proteasome subunits on particle assembly, structure, and activity" Eva M. Huber2 ∙ Wolfgang Heinemeyer2 ∙ Michael Groll3

🔬How do single amino acid changes cause severe diseases? New #Structure study uses #Yeast to reveal the structural basis of PRoteasome-Associated Autoinflammatory Syndromes; 15 crystal structures show PRAAS-linked mutations

🔗 www.yeastgenome.org/reference/S1...

#Proteasome #YeastResearch

Azidohomoalanine (AHA) Metabolic Labeling Reveals Unique #Proteomic Insights into Protein Synthesis and Degradation in Response to Bortezomib Treatment 🧬🔬🖥️🥼

www.mdpi.com/2227-7382/13...

@rpfahlman.bsky.social @ualbertapress.bsky.social @ualberta.bsky.social

#proteomes #proteoform #proteasome

Among patients with #MultipleMye­loma #MMsm treated with conventional #chemotherapy, #proteasome inhibitors, and/or #immunomodulatory agents, long-​term PFS was found to be associated with achieving complete response and being diagnosed at a younger age: https://ow.ly/eMNC50Xon5h
#HemeSky #OncSky

Traditional Chinese Medicine Erhuang Suppository for Treatment of Persistent High-risk Human Papillomavirus Infection and Its Impact on Transcriptome of Uterine Cervix - Current Medical Science Objective High-risk human papillomavirus (HR-HPV) infection is the chief cause of cervical intraepithelial neoplasia (CIN) and cervical carcinoma. The Erhuang suppository (EHS) is a traditional…

This study investigates the #therapeutic potential of #intravaginal Erhuang suppositories, which regulate #Immune responses and inhibit #Proteasome activity, offering promising avenues for targeting high-risk #HumanPapillomavirus. #medsky

To read:

In @jcb.org, Dennison and Baldridge @umich.edu reveal how the #Golgi-localized Tul1 #ubiquitin ligase complex targets substrates to the #proteasome versus the vacuole in S. cerevisiae. rupress.org/jcb/article/...

#Biochemistry #ProteinHomeostasis

Dennison and Baldridge @umich.edu reveal how the #Golgi-localized Tul1 #ubiquitin ligase complex targets substrates to the #proteasome versus the vacuole in S. cerevisiae. rupress.org/jcb/article/...

#Biochemistry #ProteinHomeostasis

Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancer Tang et al. reveal that the anti-breast cancer efficiency of bortezomib in vivo can be enhanced by TM or AMD3100 in a CD8+ T cell-dependent manner. Treatment with drug combinations activates CD8+ T ce...

Drug combinations sensitize cancer cells to #proteasome inhibitor. The drugs reduce breast cancer growth, by inducing cancer cell antigen presentation and CD8 #T-cell responses. The drug combinations increase efficacy of #immunotherapy in mouse models of breast cancer.
www.cell.com/cell-reports...

박준범 on Instagram: "Q. Which molecule helps proteins fold properly and checks if they are correctly folded? #proteinfolding #ubiquitin #proteasome #medicalmemes" 5,092 likes, 41 comments - doctorjaybe on July 1, 2025: "Q. Which molecule helps proteins fold properly and checks if they are correctly folded? #proteinfolding #ubiquitin #proteasome #medicalmemes".

Q. Which molecule helps proteins fold properly and checks if they are correctly folded?

#proteinfolding #ubiquitin #proteasome #medicalmemes

Instagram www.instagram.com/reels/DLkeVW...

Just came back from the @yicsac.bsky.social symposium at @ki.se 🇸🇪 - my final conference as a PhD student! Honoured to have won best talk for my work on #senescence and the #proteasome and grateful for all the feedback. 🏆 Now, time to wrap up in the lab and write that thesis! #yICSAKI

🙏🏻 for the highlight @frenchdcsociety.bsky.social one important finding was the very efficient #vacuolar pathway in MZ #macrophages challenging the current view that #proteasome dependent pathways (active in DC1) are prominent to generate antigenic peptides for #MHC-I through #cross-presentation

Interferon-induced PARP14-mediated ADP-ribosylation in p62 bodies requires the ubiquitin-proteasome system | The EMBO Journal imageimageInterferon induces the formation of ADP-ribosylation (ADPr)-enriched p62 bodies, requiring PARP14 and p62. Unlike canonical p62 bodies, these ADPr-enriched structures are independent of auto...

🥳 Out now @embojournal.org!
Interferon induces a new class of p62 bodies, with #antiviral & #immunotherapy implications.
p62 is usually linked to #autophagy — but not here.
These are driven by PARP14-mediated ADP-ribosylation & rely on #ubiquitin #proteasome system. www.embopress.org/doi/full/10....

The proteasome activator subunit PSME1 promotes HBV replication by inhibiting the degradation of HBV core protein

This study shows that proteasome activator subunit 1 (PSME1) is a potent #HBV-associated host factor. Upon interacting with HBc, PSME1 inhibits its degradation by the 26S #proteasome, highlighting a promising therapeutic approach for treating HBV-linked diseases. #medsky

Read: buff.ly/v3uYUM1

Substrates bind to residues lining the ring of asymmetrically engaged bacterial proteasome activator Bpa - Nature Communications Mycobacterium tuberculosis has a proteasome similar to eukaryotes. This study reveals how the activator Bpa recruits its substrate HspR, providing structural and mechanistic insights. The authors iden...

Check out our new study revealing how ATP-independent activator Bpa binds asymmetrically to the Mtb #proteasome — and pinpointing key Bpa residues involved in substrate interaction.
👏 Tatjana v. Rosen, Rafal Zdanowicz & @yasser-elhadeg.bsky.social
🔗 www.nature.com/articles/s41...

Understanding neurodevelopmental proteasomopathies as new rare disease entities: A review of current concepts, molecular biomarkers, and perspectives

Reviewing primary proteasompathies associated with #CognitiveImpairment, the cellular changes induced by genomic alterations in #proteasome genes & their relevance as #biomarkers for diagnosis & treatment of #proteasompathies. @cnrs.fr @inserm.fr

#OpenAccess: www.sciencedirect.com/science/arti...

What a timing! We just heard about this amazing story a moment ago at the #FCQC2025, and we can already dig further and read the paper! 😁 Congratulations, Leo and team! #ubiquitin #proteasome

Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...

Wild.

Cell-intrinsic #proteasome derived #defense peptides.

@nature.com

www.nature.com/articles/s41...

Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...

The Proteasome: Our tiniest defender against Bacteria [via Nature] 🧪⚗️🧬🦠🔫

These tiny defenders, present in every cell, detect #bacterial #infection and change their protein #recycling role into antibiotic #protein creation.

www.nature.com/articles/s41...

#proteasome #immune #system #antibiotics

Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...

Cool!
#Proteasome #Innate #Immunity

www.nature.com/articles/s41...

Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...

Proteasomes do more than degrade proteins—they generate defense peptides (PDDPs) that disrupt bacterial membranes, providing a first line of cell-autonomous immunity. Infection enhances PDDP production via PSME3-driven proteasomal shifts. #nature #Proteasome

Nature: www.nature.com/articles/s41...

In the midst of the dark ages, we MUST retain optimism—keep going, keep publishing, keep talking science, and keep doing fun experiments! Our latest paper on the fascinating TF SKN-1/NRF presents exciting new findings using our one and only #Celegans #genetics #oxidativestress #proteasome

Regulation of N-degron recognin-mediated autophagy by the SARS-CoV-2 PLpro ubiquitin deconjugase Viral proteases play critical roles in the host cell and immune remodeling that allows virus production. The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) papain-like protease (PLpro...

In our latest study, we report on how the SARS-CoV-2 protease PLpro manipulates autophagy. Paper in the Journal #Autophagy. #Covid, #Ubiquitin, #Proteasome. bit.ly/3E7cByg

Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors The proteasome is considered an excellent drug target for many infectious diseases as well as cancer. Challenges with robust and safe supply of proteasomes from infectious agents, lack of structural information, and complex pharmacology due to multiple active sites have hampered progress in the infectious disease space. We recombinantly expressed the proteasome of the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease, and demonstrate pharmacological equivalence to the native T. cruzi proteasome.

Great to see the final version of our latest paper now published! We recombinantly produced the #Trypanosoma cruzi #proteasome, determined its cryo-EM structure, revealed substrate promiscuity and generated multiple mutants for better pharmacological understanding. www.jbc.org/article/S002... 🧪

This Special issue seeks to highlight the current understanding of key factors that regulate #proteasome activity. Gaining these insights could pave the way for developing strategies to enhance the effectiveness of targeted therapies. We invite you to contribute your relevant findings here.

Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors The proteasome is considered an excellent drug target for many infectious diseases as well as cancer. Challenges with robust and safe supply of proteasomes from infectious agents, lack of structural i...

Delighted that our work on the Trypanosoma cruzi #proteasome is now accepted by The Journal Of Biological Chemistry and available online!🧪

www.jbc.org/article/S002...

Any #proteasome or #immunoproteasome people here already? A side project developed towards proteasomal degradation and I could use some review/paper recommendations as well as names of labs that are leading the field 🙏🤗