Men, Hirayama, Murata et al. show that misfolded protein aggregates are degraded through #microautophagy, a process mediated by the UBAP1-containing ESCRT-I complex and PTPN23. rupress.org/jcb/article/...

📕 In Cellular Neurobiology collection: rupress.org/jcb/collecti...
#SfN25

Fantastic and productive meeting with the labs of Tamotsu Yoshimori, Shuhei Nakamura, Akiko Kuma at #Osaka University. Discussing perspectives of #microautophagy in th #lysosome regeneration after damage. Thanks so much for hosting me.

ESCRT-I and PTPN23 mediate #microautophagy of ubiquitylated tau aggregates, say Yusen Men, Shoshiro Hirayama, Shigeo Murata @utokyoofficial.bsky.social and colleagues: rupress.org/jcb/article/...

#Autophagy #ProteinHomeostasis #Biochemistry #Neuroscience

Men, Hirayama, Murata et al. @utokyoofficial.bsky.social show that misfolded protein aggregates are degraded through #microautophagy, a process mediated by the UBAP1-containing ESCRT-I complex and PTPN23. rupress.org/jcb/article/...

#autophagy #neuroscience #proteinhomeostasis