Alpha-Synuclein Preformed Fibrils Buy high-quality Alpha-Synuclein Preformed Fibrils (PFF) for research use. rPeptide offers recombinant peptides and proteins ideal for scientific and laboratory research studies.

Check out our Alpha-Synuclein Preformed Fibrils (ASF-1001) for your research needs!

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#Neuroscience #AlphaSynuclein #Fibrils #PFF #ParkinsonsResearch #Neurodegeneration #rPeptide

Protein structure and coupled solvent dynamics in α-synuclein fibrils under controlled confinement The formation of amyloid fibrils by the intrinsically disordered protein α-synuclein in human brain neurons and extracellular tissue is a hallmark of Parkinson disease. Although the stable protein β-s...

How do toxic protein clumps form in #ParkinsonDisease and what keeps them around? A new Cell study zooms in on Alpha-Synuclein fibrils and the water molecules around them to find out. Research conducted using rPeptide's ASF-1001. 🧠

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#Neuroscience #AlphaSynuclein #ProteinResearch

Company Updates: Spring 2026 | StressMarq StressMarq’s product development is driven by an ongoing dialogue between our scientists & the research community. Learn about our new products for Spring 2026.

🌱 StressMarq is excited to welcome spring with a fresh lineup of #AlphaSynuclein, #Tau, and #AmyloidBeta products.

🔎 Discover our approach to product innovation, upcoming conferences, and our ongoing commitment to advancing #neurodegeneration research worldwide 🌸 https://bit.ly/40VPtLf

Tubulin Combats Neurodegeneration by Blocking Toxic Protein Aggregates in In a groundbreaking advancement in neurodegenerative disease research, scientists at Baylor College of Medicine have uncovered a promising new mechanism for combatting conditions such as Alzheimer’s a

#Tubulin Combats #Neurodegeneration by Blocking Toxic Protein Aggregates in the #Brain, #Alzheimers #Parkinsons #Tau #alphasynuclein @bcmhouston.bsky.social bioengineer.org/tubulin-comb...

Boosting Tubulin Could Prevent Protein Clumping in Neurodegenerative Diseases Tubulin alters the behavior of tau and alpha-synuclein, preventing them from forming harmful clumps and instead promoting microtubule assembly.

A Ferreon, L Lucas et al reveal tubulin as a potential protector against toxic protein aggregation #Tau #AlphaSynuclein #Alzheimers #Parkinsons @natcomms.nature.com @bcmhouston.bsky.social www.insideprecisionmedicine.com/topics/patie...

Our paper on disease mechanisms in synucleinopathies, led by Tetiana Serdiuk, is out at Molecular Systems Biology.

#proteomics #structuralproteomics #neurodegeneration #Parkinsons #alphasynuclein #structuralbiology #ethz
@imsb-eth.bsky.social @molsystbiol.org

Alpha-Synuclein High quality recombinant Alpha-Synuclein, >95% purity. Highly monomeric, batch to batch consistency. Order online today - R&D starts at rPeptide.

Check out our Recombinant Alpha-Synuclein (Cat # S-1001) for your research needs!

www.rpeptide.com/product/alph...

Contact Sales@rPeptide.com for a quote or place an order online!

#Neuroscience #AlphaSynuclein #ASyn #LewyBodyDementia #Parkinsons #ResearchReagents #rPeptide

Diagnostic Performance of the α-Synuclein Seed Amplification Assay for Dementia With Lewy Bodies | Neurology Background and ObjectivesThe α-synuclein (α-syn) seed amplification assay (SAA) has shown promising results for diagnosing dementia with Lewy bodies (DLB) using CSF samples. A barrier to implementing ...

An α-Syn seed amplification assay shows promise for detecting Lewy body dementia via CSF, helping differentiate synucleinopathies from AD for earlier, more accurate diagnosis. Powered in part by rPeptide's recombinant Alpha-Synuclein. 🧬🧠

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#AlphaSynuclein #LewyBody #Parkinsons #rPeptide

rPeptide's new ABT Fibril Complex consists of Tau-441, Beta-Amyloid 1-42, and Alpha-Synuclein together in one validated system. Built for the complexity of real Alzheimer's pathology. 🔬

ABT Fibril Complex: t.ly/g4Jpk

#rPeptide #PFFs #Alzheimers #Neurodegeneration #Tau #AlphaSynuclein #BetaAmyloid

Tubulin May Prevent Against Alzheimer’s and Parkinson’s - Neuroscience News Tubulin acts as a master regulator, preventing Tau and alpha-synuclein from forming toxic clumps in Alzheimer's and Parkinson's.

Study from the A. Ferreon lab, L. Lucas et al supports that #Tubulin can curb #Tau and #alphasynuclein toxic aggregation toward their healthy roles, a potential therapeutic strategy. @natcomms.nature.com @bcmhouston.bsky.social @neurosciencenews.bsky.social neurosciencenews.com/tubulin-tau-...

Product Citation 🪐

In flies, downregulation of mino/GPAT shields against #AlphaSynuclein toxicity, enhancing neuronal survival. Mouse studies utilized StressMarq's αSyn PFFs & Monomers.

Paper 🚀 https://go.nature.com/4aOoN3D
Products🌙 https://bit.ly/2u9YHV2 | https://bit.ly/46ndG05

New Assay Helps to Identify Elevated Dementia Risk The approach relies on the detection of pathological alpha-synuclein proteins.

Researchers from #DZNE & partners have developed a method to quantitatively measure pathological #AlphaSynuclein in cerebrospinal fluid, which may facilitate the identification of individuals at elevated risk of #dementia.
👉 www.dzne.de/en/im-fokus/...

The image contains four graphs related to mismatch models for Penn Antiamyloid Therapy Monitoring (ATM). Graph A shows measured vs predicted CDR-SB score with a trend line. B shows time from tau positivity relative to plasma p-tau217. C predicts change in CDR-SB score over time, D displays expected change in CDR-SB score over 18 months of treatment; Resilient, Canonical and Vulnerable groups are compared.

Individuals with #AlzheimerDisease showing greater clinical impairment than predicted by tau burden are more likely to have copathology, including #TDP43 and #AlphaSynuclein, and experience faster decline.

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N15 Alpha-Synuclein, Uniformly Labeled High quality recombinant N15 Alpha-Synuclein, >95% purity. Highly monomeric, batch to batch consistency. Order online today - R&D starts at rPeptide.

To monitor A-Syn behavior and self-assembly in detail, the researchers used rPeptide’s N15 Alpha Synuclein (Cat # S-1004) as a labeled protein tool.

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Our 𝛼-Synuclein helped track structural shifts and validate strategies to disrupt toxic assemblies.

#AlphaSynuclein #N15 #rPeptide

Impairment in stimulus-response learning as a cognitive biomarker in a model of synucleinopathy - Translational Psychiatry Translating findings from preclinical assessments of cognitive function relevant to synucleinopathies into successful clinical trials poses significant challenges. In this study, we examined the effectiveness of human-relevant touchscreen cognitive a...

Product Citation 🍁

Researchers @westernu.ca utilized StressMarq's #AlphaSynuclein PFFs to create touchscreen cognitive tests that detect early stimulus-response learning deficits in a mouse model of #synucleinopathy.

Paper 🛶 https://go.nature.com/3LPaC5K
Product 🌲 https://bit.ly/2u9YHV2

Dopaminergic neurodegeneration in the substantia nigra is associated with olfactory dysfunction in mice models of Parkinson’s disease - Cell Death Discovery Cell Death Discovery - Dopaminergic neurodegeneration in the substantia nigra is associated with olfactory dysfunction in mice models of Parkinson’s disease

Early loss of smell may be more than a symptom, it may reflect early #Parkinsons pathology.

A new study shows #AlphaSynuclein aggregation drives both neuron loss and olfactory deficits in PD models. rPeptide’s Alpha-Synuclein and ready-to-use PFFs supported this work.

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#rPeptide

Product Citation ❄️

Injecting StressMarq's #AlphaSynuclein PFFs into A53T mice induced significant #PD pathology, neuroinflammation, BBB disruption, T-cell infiltration & major loss of dopaminergic neurons.

Paper 🔷 https://bit.ly/4pXJKiF | PFFs🔹https://bit.ly/2u9YHV2 & https://bit.ly/2J8a4Bz

Product Citation 🦋

The FAM49B gene is downregulated in the normal aging process & in #PD pathology. StressMarq's #AlphaSynuclein PFFs helped to reveal that decreased FAM49B levels disrupt key #microglial functions.

Paper 🌼 https://go.nature.com/491OZIh
PFFs 🌺 https://bit.ly/2u9YHV2

Product Citation 🥠

Utilization of StressMarq's #AlphaSynuclein constructs helped validate the immuno-infrared-sensor (iRS) platform for the detection of misfolded αSyn in blood serum, without preprocessing.

Paper 🎊 https://bit.ly/4q0z9n9
αSyn 🪁 https://bit.ly/48w0J27

#neurodegeneration

Product Citation: #AlphaSynuclein & #Tau cross-seeding drives diverse #amyloid structures with distinct cell impacts, suggests a study that employed StressMarq's proteins for #neurodegeneration research.

Paper ⭐ https://bit.ly/4fEc2uz
αSyn 💫 https://bit.ly/48w0J27
Tau ✨ https://bit.ly/3RKlyli

The Role of Alpha-Synuclein in Neurodevelopmental Diseases Can a protein aid autism diagnosis? Review suggests α-synuclein links to neurodevelopmental disorders, aiding early detection. #Autism #AlphaSynuclein

Can a protein aid autism diagnosis? Review suggests α-synuclein links to neurodevelopmental disorders, aiding early detection. #Autism #AlphaSynuclein
www.rimpacts.com/rd/p?c=10077... 📄DOI: doi.org/10.1007/s120...

Product Citation: Neuroimmune activation is an early marker of Parkinson’s disease pathology. Exogenous uptake of oligomeric #AlphaSynuclein by cortical microglia was visualized using StressMarq’s Kinetically-Stable #aSyn Oligomers.

Paper ⚡ https://bit.ly/4gW8ZOG
Product ☀️ https://bit.ly/491ImDG

Molecular mechanisms of α-syn abnormal phase separation in cognitive impairment induced by chronic intermittent hypoxia and the neuroprotect... The pathological association between α-synuclein (α-syn) deposition and neurodegeneration or cognitive dysfunction has been extensively studied f

Product Citation💡

A study from Binzhou Medical University used StressMarq's #AlphaSynuclein Antibody to demonstrate that ROS-regulated abnormal phase separation of α-syn is a novel mechanism underlying CIH-induced #neuronal damage.

Paper🌲https://bit.ly/4agG72n
Product 🍃 https://bit.ly/48t6jod

Figure 4. Graphs show mismatch models in Penn Antiamyloid Therapy Monitoring(ATM) cohort. Graph A is classification, B is time calculation from tau positivity. Graphs C and D show change in CDR-SB score over treatment time and after 18 months.

Individuals with #AlzheimerDisease showing greater clinical impairment than predicted by tau burden are more likely to have copathology, including #TDP43 and #AlphaSynuclein, and experience faster decline. ja.ma/3KLq5Du

Anti-Alpha Synuclein Antibody - Mouse Monoclonal [4F1] Mouse Anti-Mouse Alpha Synuclein Monoclonal IgG1 from StressMarq. Suitable for WB, DB, IHC, ICC/IF, ELISA. High-quality antibodies for scientific research.

Product Citation 🔬

Scientists at Case Western Reserve University used StressMarq's #AlphaSynuclein Antibody to examine the role of C19orf12 in the brain, within the context of #neurodegeneration with brain iron accumulation.

Paper 🧠 https://bit.ly/3KcPGF9
Product 🧫 https://bit.ly/4p1hOKo

A Novel Long Non-Coding RNA Regulates Tau Degradation Long non-coding RNA FAM151B-DT links tau and α-synuclein degradation, uncovering a potential therapeutic target for neurodegenerative diseases.

🔬 The long non-coding RNA FAM151B-DT promotes the autophagic clearance of #AlphaSynuclein and #Tau, making it a promising therapeutic target across multiple #neurodegenerative disorders.

Read more about these exciting findings on the StressMarq blog 🧬 https://bit.ly/4p89fgW

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🧠 🚨 : A novel dual-site AAV rat model of #LewyBodyDisorders enables layer-by-layer hippocampal analysis. Rapamycin alleviates cognitive deficits & reduces α-syn pathology, especially across CA2 sublayers. #alphasynuclein #CA2 #autophagy
Here is our latest paper 🍀

🔎 lnkd.in/dEeJ-62W

Adoptive NK cell transfer confers neuroprotection by attenuating neuroinflammation and alpha-synuclein pathology in a mouse model of synucleinopathy - Molecular Neurodegeneration Advances Background Natural killer (NK) cells are key effector lymphoid cells involved in both innate and adaptive immunity and are capable of clearing abnormally aggregated α-synuclein (αSyn). In preclinical ...

Adoptive NK cell transfer confers #neuroprotection by attenuating #neuroinflammation and #alphasynuclein pathology in a mouse model of #synucleinopathy

Adetutu Adebowale, Jung Ha Byun, Jaegwon Chung..Jae-Kyung Lee @universityofga.bsky.social #Parkinsons

link.springer.com/article/10.1...

Product Citation: C-terminal cleavage of #AlphaSynuclein enhances aggregation & seeding in #Parkinsons disease pathology. StressMarq’s ATTO 594 αSyn PFFs enabled visualization of this process in a neuron-astrocyte co-culture.

Paper ⛩️ https://bit.ly/3KMbAz1
Product 🌸 https://bit.ly/3Tcoetj