New paper out: Psychometric reliability of patient-reported visual analogue scales in subthalamic nucleus deep brain stimulation programming for Parkinson's disease.: Off, Johannes; Scherer, Maximilian; Peschke, Sophia; et al.
Brain communications Vol. 8, no. 2,⊠| Thanks for sharing #dzne #papers
New paper out: Association of Blood-Based Biomarkers and Malignant Infarction in Severe Anterior Circulation Ischemic Stroke.: Lehrieder, Dominik; Neugebauer, Hermann; Kollikowski, Alexander M; et al.
Brain and behavior Vol. 16, no. 4, p. e71333 | Thanks for sharing #dzne #papers
New paper out: rTCT: Rodent Triangle Completion Task to Facilitate Reverse Translational Study of Path Integration.: Duncan, Stephen; Rehman, Sulaiman; Segen, Vladislava; et al.
Hippocampus Vol. 36, no. 3, p. e70090 | Thanks for sharing #dzne #papers
New paper out: Midsagittal Midbrain Area and Midbrain-to-Pons-Ratio Cannot Distinguish Overlap Syndromes Between Amyotrophic Lateral Sclerosis and Progressive Supranuclear Palsy.: Cantré, Daniel; König, Jochem; Makowsky, Caroline; et al.
Clinical neuroradiology⊠| Thanks for sharing #dzne #papers
New paper out: Reply to: Utility of Progression Rate Since Symptom Onset in Predicting Subsequent Survival in Progressive Supranuclear Palsy.: Quattrone, Andrea; Franzmeier, Nicolai; Höglinger, GĂŒnter U
Movement disorders Vol. 41, no. 1, p. 279 - 280 | Thanks for sharing #dzne #papers
New paper out: Cost-Effectiveness Modelling of Multiple System Atrophy for Early Health Technology Assessment.: Grand, Tobias Sydendal; Ren, Shijie; Thokala, Praveen; et al.
PharmacoEconomics - open Vol. 10, no. 1, p. 179 - 196 | Thanks for sharing #dzne #papers
New paper out: How alexithymia shapes functional networks: Insights from a general population study.: Krause, Elischa; Klinger-König, Johanna; Goerlich, Katharina S; et al.
European psychiatry Vol. 69, no. 1, p. e45 | Thanks for sharing #dzne #papers
New paper out: Impact of lifestyle factors on quantitative motor and cognitive performance: insights from a longitudinal study on healthy ageing.: Zimmermann, Milan; SĂŒnkel, Ulrike; Wurster, Isabel; et al.
GeroScience Vol. 48, no. 1, p. 1259 - 1275 | Thanks for sharing #dzne #papers
New paper out: Emotion recognition in patients with mild cognitive impairment: The role of face processing and emotional intelligence.: Mahadevan, Rachana; Giesers, Naomi Kristin; Liman, Thomas; et al.
Journal of Alzheimer's disease Vol. 110, no. 1, p.⊠| Thanks for sharing #dzne #papers
New paper out: Reduced osteogenic factors and early osteoblast senescence in SOD1(G93A) ALS mouse model.: Ăzkan, Burak; Ramge, Jan-Moritz; Wiesner, Diana; et al.
JCI insight Vol. 11, no. 5, p. e197475 | Thanks for sharing #dzne #papers
Maintaining and regaining episodic memory in Alzheimer disease: a circuit-based perspective.
Emrah DĂŒzel, Michael R. Kreutz.
Nature Reviews Neurology (2026).
DOI : doi.org/10.1038/s415...
... that cognitive decline can result from inefficient use of existing neural networks, not just structural damage. Some impairments may be reversible through targeted interventions that restore network coordination. (2/2)
Illustration of neurons with branching extensions forming a network of brain cells. Made with AI
Memory loss in Alzheimerâs disease is not explained by neuron loss alone. A review in @natrevneurol.nature.com shows that disruptions in neural network function play a key role, highlighting new directions for diagnosis and treatment.
The âCircuit Utilization Frameworkâ proposes ... (1/2)
đž AI
On #WorldHealthDay: Dr. Anna Aschenbrenner of DZNE explains why the immune fingerprint is the key to understanding disease risk at the individual level, and why mapping it across all of humanity is the next frontier.
#StandWithScience @dzne.science @immunosens.bsky.social
đ„ youtu.be/wzMxWN7ZJPw
Great new work from our lab: #Microglia #glioblastoma interaction in vivo analyzed deep in the corpus callosum wirh #3photon microscopy by @felixnebeling.bsky.social
doi.org/10.1016/j.im...
#neuroscience đ§Ș @dzne.science
Picture of the BonnBrain 2026 Organisers (Martin Fuhrmann, Tobias Rose, Bettina Schnell & Sabine Krabbe)
It's a wrap! Grateful for this incredible #BonnBrain26 team.
Many thanks to our fantastic support crew of the @dzne.science, @mpinb.mpg.de and @unibonn.bsky.social - we could not have done this without you!
See you in 2028 for the next edition!
Donât miss our labâs posters at @bonnbrainconf.bsky.social, featuring exciting new work from Eva Sebastian, @paricio-montesinos.bsky.social & Ziyan Huang on large-scale neuronal activity in sensory thalamus function, decision-making, sleep & inhibitory regulation. đ§ đŹ @dzne.science #BonnBrain26
Elevated Blood đ©ž p-Tau181, p-Tau217 Not Unique to Alzheimerâs Disease đ§ Alzforum reports on recent findings by @mathiasjucker.bsky.social and coworkers published in @natmed.nature.com
đ www.alzforum.org/news/researc...
đ·: DZNE/Frommann
New paper out: Large-scale mapping of the MCH network in ALS mice reveals the vulnerability of dopaminergic and GABAergic neurons in zona incerta: Scekic-Zahirovic, Jelena; Antonucci, Stefano; Wiesner, Diana; et al.
Acta Neuropathologica Communications Vol. 14,⊠| Thanks for sharing #dzne #papers
Multi-modal dissection of cell-type specific TDP-43 pathology in the motor cortex.
Wolfgang Ruf et al.
@natcomms.nature.com (2026).
DOI: 10.1038/s41467-026-69944-6 / URL: www.nature.com/articles/s41...
Researchers from DZNE and collaborators have discovered that aggregates of protein TDP-43, a hallmark of the neurodegenerative diseases ALS and FTD, primarily affect specific brain cells đ§ .
đ www.dzne.de/en/im-fokus/...
New paper out: Exploring neural correlates of automated speech-based cognitive markers through resting-state functional connectivity in aging and at-risk Alzheimer's disease.: Li, Qingyue; Alexopoulou, Zampeta-Sofia; Dyrba, Martin; et al.
Alzheimer's research &⊠| Thanks for sharing #dzne #papers
New paper out: TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism.: Feiten, Astrid Feentje; Dahm, Kilian; Schlepckow, Kai; et al.
Nature Communications Vol. 17, no. 1, p. 2002 | Thanks for sharing #dzne #papers
Blood phosphorylated Tau elevation in immunoglobulin light chain and transthyretin amyloidosis.
Stephan Kaeser, Stephanie Schultz, Anna Hofmann.
@natmed.nature.com (2026).
DOI: 10.1038/s41591-026-04272-2
đ©ž A blood protein seen as an early marker of Alzheimerâs đ§ may also play a role in other diseases: Researchers at DZNE and @hih-tuebingen.bsky.social found elevated phosphorylated tau (pTau) levels in two rare conditions affecting the heart đ and kidneys.
đ www.dzne.de/en/im-fokus/...
New paper out: Alterations in cerebrospinal fluid levels of myelin- and oligodendrocyte-related proteins in sporadic CreutzfeldtâJakob disease: Maass, Fabian; Thomas, Carolina; Kurvits, Lille; et al.
Acta Neuropathologica Communications Vol. 14, no. 1, p. 51 | Thanks for sharing #dzne #papers
New paper out: A physically and mentally active lifestyle relates to younger brain and cognitive age: Behrenbruch, Niklas; Schwarck, Svenja; Schumann-Werner, Beate; et al.
GeroScience | Thanks for sharing #dzne #papers
New paper out: Proton channel Hv1 modulates microglial responses to neurological disorders: Stratmann, Maite; Gagliardi, Caterina; Capasso, Melania
Frontiers in biophysics Vol. 3, p. 1681011 | Thanks for sharing #dzne #papers