Infiltration of glioblastoma (GB) cells into the brain parenchyma and colonization of distant regions are associated with disease recurrence and therapy resistance. Using 3-photon intravital microscopy in an autochthonous GB model, Nebeling et al. identify structured, stage-dependent microglial responses at the far infiltration zone and show that microglial manipulation modulates tumor microtube plasticity and invasion.
🚨New paper from the lab🚨
Felix shows that #microglia shape #glioblastoma invasion at the far infiltration zone. Using in vivo #3photon #imaging, he finds dynamic responses & shows that manipulation reduces GB migration & limits #tumormicrotube #plasticity:
📝 doi.org/10.1016/j.im...
#Neuroscience🧪
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