Impairment in stimulus-response learning as a cognitive biomarker in a model of synucleinopathy - Translational Psychiatry Translating findings from preclinical assessments of cognitive function relevant to synucleinopathies into successful clinical trials poses significant challenges. In this study, we examined the effectiveness of human-relevant touchscreen cognitive a...

Product Citation 🍁

Researchers @westernu.ca utilized StressMarq's #AlphaSynuclein PFFs to create touchscreen cognitive tests that detect early stimulus-response learning deficits in a mouse model of #synucleinopathy.

Paper 🛶 https://go.nature.com/3LPaC5K
Product 🌲 https://bit.ly/2u9YHV2

Adoptive NK cell transfer confers neuroprotection by attenuating neuroinflammation and alpha-synuclein pathology in a mouse model of synucleinopathy - Molecular Neurodegeneration Advances Background Natural killer (NK) cells are key effector lymphoid cells involved in both innate and adaptive immunity and are capable of clearing abnormally aggregated α-synuclein (αSyn). In preclinical ...

Adoptive NK cell transfer confers #neuroprotection by attenuating #neuroinflammation and #alphasynuclein pathology in a mouse model of #synucleinopathy

Adetutu Adebowale, Jung Ha Byun, Jaegwon Chung..Jae-Kyung Lee @universityofga.bsky.social #Parkinsons

link.springer.com/article/10.1...

Research models to study lewy body dementia - Molecular Neurodegeneration Lewy body dementia (LBD) encompasses neurodegenerative dementias characterized by cognitive fluctuations, visual hallucinations, and parkinsonism. Clinical differentiation of LBD from Alzheimer’s dise...

'Research models to study #LewyBodyDementia'

Suelen Lucio Boschen, Aarushi A. Mukerjee, Ayman H. Faroqi, Ben E. Rabichow...John Fryer #Parkinsons #synucleinopathy

bit.ly/3EAS4Tf

This 'pure' group is important.

It's a #synucleinopathy with autonomic involvement and many have central involvement (RBD) yet don't develop motor or cognitive impairment leading to #MSA #PD or #DLB

And many thanks to my amazing colleagues & mentors @MayoClinicNeuro

Many thanks to all involved patients and contributors @unispitalzuerich.bsky.social

#Neuroscience #Parkinsons #SleepMedicine #OpenScience #Tauopathy #Synucleinopathy

Diagnosing Synucleinopathies: Will Parkinson's Disease or Dementia with Lewy Bodies Become ‘Biologically’ Defined? Parkinson’s disease (PD) is the second-most common neurodegenerative disease after Alzheimer’s disease (AD), with an estimated...

Disease-modifying trials for #ParkinsonsDisease have faced setbacks. Could a "biological definition" using biomarkers be the key to earlier intervention & better outcomes? Learn about the future of #synucleinopathy diagnosis! #neurology #biomarkers
doi.org/10.33590/emj...

Pathology of #multiplesystematrophy (MSA). Here is your quiz. When I teach resident courses on this topic folks know this is a #synucleinopathy however they forget the glial cytoplasmic inclusions. Can you spot them in Dennis Dickson's @MayoClinic beautiful pic? @OGdukeneurosurg