A new study in #GENETICS from @hendersi.bsky.social’s group explores how natural variation in #Arabidopsis influences centromere-proximal crossover frequency and segregation distortion when #centromeres are heterozygous. buff.ly/Ev5Xrro
Another beauty from our recent study!
𝐇𝐨𝐥𝐨𝐓𝐫𝐚𝐜𝐤𝐢𝐧𝐠 thousands of holocentromeres' synteny across 40 MY of evolution
Turns out holocentromeres can be stable in identity but wildly dynamic in structure. 🧬
If you want to read more about it, here: www.biorxiv.org/content/10.6...
#Centromeres #Pangenome
Insights into natural neocentromere evolution from a cattle T2T X chromosome. #CattleGenome #T2T #HaplotypeResolvedGenome #Centromeres #Genomics @natcomms.nature.com 🧪🧬 🖥️
www.nature.com/articles/s41...
Complete genome assemblies of two mouse subspecies reveal structural diversity of telomeres and centromeres. #MouseGenomes #StructuralVariants #TsT #Centromeres #Genomics @natgenet.nature.com
www.nature.com/articles/s41...
In a new study published in Horticulture Research, researchers unveiled the first complete genome of F. suspensa.
#Centromeres #Forsythia
Details: doi.org/10.1093/hr/uhae185
Researchers from #InstitutCurie and #HannoverMedicalSchool (MHH) have shown that #centromeres - chromosomal regions critical for #celldivision - play a direct role in activating the #immunesystem, opening new doors for next-generation #cancer or #antiviral #immunotherapy www.cell.com/cell/abstrac...
New logo for the @centromellone.bsky.social 🪰
👩🔬Mellone group explores how cells pass on genetic information focusing on #centromeres, the critical regions that guide #chromosome segregation. Using the genetic power of #Drosophila, they uncover the molecular rules of chromosome #inheritance 🧬
5. The satellite SST1, which is a breakpoint in #Robertsonian translocations, is enriched in recombinogenic G4 motifs and Z-DNA.
6. Non-B DNA display species- and chromosome-specific trends at #centromeres.
Scientists reveal #evolutionary dynamics of #centromeres in #octoploid #strawberries.
#CENH3-specific_antibody #genomics
phys.org/news/2025-03...
The essential N-terminal domain (END) of yeast CENP-A homolog Cse4 stabilizes its localization at #centromeres via binding to #kinetochore proteins Okp1 and Ame1
@suebiggins.bsky.social sky.social and collaborators @hutchbasicsci.bsky.social @fredhutch.bsky.social
www.embopress.org/doi/full/10....
RAD52 dominates DNA repair at #centromeres over RAD51 & NHEJ's factors, leading to apoptotic cell death. Centromeric DSBs reveal nuanced repair pathway choices. #genomics #research PMID:39360606, Nucleic Acids Res 2024, @NAR_Open
Presentation by @khmiga.bsky.social - Discoveries from the
#T2T project. Using #long-read technologies like @pacbio.bsky.social and @nanoporetech.com, Miga et al. explored the structure and function of #centromeres, #telomeres, and other complex regions of the #genome 🧪 🧬 🖥️ 👩🔬
youtu.be/t4kGX373EEQ
The complete genome assembly of Nicotiana benthamiana reveals the genetic and epigenetic landscape of centromeres. #NicotianaBenthamiana #ChromosomeLevelAssembly #Centromeres #Genomics #SciSky #BioSky @natureplants.bsky.social
www.nature.com/articles/s41...
Targeting conserved regions of #kinetochore proteins KNL1 and NDC80 provides antibodies for labeling #centromeres across a spectrum of seed plants ! Great collaboration led my the Macas lab www.biorxiv.org/content/10.1...
How do changes at chromosomes of #oocytes promote #aneuploidy when women age? Melina Schuh's team @SchuhLab @MissMeiosis and @BournHallClinic found signs of aging at #centromeres and #kinetochores: https://www.mpibpc.mpg.de/17105301/pr_1928 @CurrentBiology
How do changes at chromosomes of #oocytes promote #aneuploidy when women age? Melina Schuh's team @SchuhLab @MissMeiosis and @BournHallClinic found signs of aging at #centromeres and #kinetochores: https://www.mpibpc.mpg.de/17105301/pr_1928 @CurrentBiology
How do changes at chromosomes of #oocytes promote #aneuploidy when women age? Melina Schuh's team @SchuhLab @MissMeiosis and @BournHallClinic found signs of aging at #centromeres and #kinetochores: https://www.mpibpc.mpg.de/17105301/pr_1928 @CurrentBiology
How do changes at chromosomes of #oocytes promote #aneuploidy when women age? Melina Schuh's team @SchuhLab @MissMeiosis and @BournHallClinic found signs of aging at #centromeres and #kinetochores: https://www.mpibpc.mpg.de/17105301/pr_1928 @CurrentBiology
How do changes at chromosomes of #oocytes promote #aneuploidy when women age? Melina Schuh's team @SchuhLab @MissMeiosis and @BournHallClinic found signs of aging at #centromeres and #kinetochores: https://www.mpibpc.mpg.de/17105301/pr_1928 @CurrentBiology
How do changes at chromosomes of #oocytes promote #aneuploidy when women age? Melina Schuh's team @SchuhLab @MissMeiosis and @BournHallClinic found signs of aging at #centromeres and #kinetochores: https://www.mpibpc.mpg.de/17105301/pr_1928 @CurrentBiology
