Assembly and phospho-regulatory mechanisms of the budding yeast outer #kinetochore KMN complex. New study from Noah N. Turner (@noahnturner.bsky.social), David Barford and colleagues @mrclmb.ac.uk:
rupress.org/jcb/article/...

#CellDivision #StructuralBiology #kinetochores #centromeres #cryoEM

@noahnturner.bsky.social, Barford et al reveal conserved underlying mechanisms of complex assembly, auto-inhibition, & phosphoregulation that ensure precise control of KMN assembly onto #centromeres to enable genome division. rupress.org/jcb/article/...

#kinetochores #cryoEM #biochemistry #genetics

Designing protein-based artificial kinetochores as decoys to prevent meiotic errors in oocytes - Nature Cell Biology Zhou et al. design protein-based artificial kinetochore constructs as decoys to prevent premature chromosomal separation in aged oocytes. These constructs compete with chromosomal kinetochores, reduci...

Team led by Tomoya Kitajima designed protein-based artificial #kinetochores to act as decoys to reduce bipolar microtubule pulling forces on chromosomes in aged mouse #oocytes, preventing premature #ChromosomeSegregation during meiosis I & II.
In @natcellbio.nature.com
👇
doi.org/10.1038/s415...

How egg cells control the timing of cell division RIKEN researchers have found that MPS1 promotes timely spindle bipolarization, preventing kinetochore–microtubule attachment errors in oocytes.

📃Read a #ResearchHighlight on a study led by Shuhei Yoshida & Tomoya Kitajima (Lab for Chromosome Segregation) in which they find MPS1 proteins play a key role to ensure spindle bipolarization occurs before #kinetochores attach to microtubles in #oocytes during #meiosis.
www.riken.jp/en/news_pubs...

⭐ NAR Breakthrough! ⭐
🔬 How do #kinetochores rebuild each #cellcycle?
A new study reveals the order of assembly, hidden interdependencies, and a new regulatory mechanism.
🧬 Read more: academic.oup.com/nar/article/... @suebiggins.bsky.social @fredhutch.org

#NARbreakthrough #ChromosomeSegregation

How do changes at chromosomes of #oocytes promote #aneuploidy when women age? Melina Schuh's team @SchuhLab @MissMeiosis and @BournHallClinic found signs of aging at #centromeres and #kinetochores: https://www.mpibpc.mpg.de/17105301/pr_1928 @CurrentBiology

How do changes at chromosomes of #oocytes promote #aneuploidy when women age? Melina Schuh's team @SchuhLab @MissMeiosis and @BournHallClinic found signs of aging at #centromeres and #kinetochores: https://www.mpibpc.mpg.de/17105301/pr_1928 @CurrentBiology

How do changes at chromosomes of #oocytes promote #aneuploidy when women age? Melina Schuh's team @SchuhLab @MissMeiosis and @BournHallClinic found signs of aging at #centromeres and #kinetochores: https://www.mpibpc.mpg.de/17105301/pr_1928 @CurrentBiology

How do changes at chromosomes of #oocytes promote #aneuploidy when women age? Melina Schuh's team @SchuhLab @MissMeiosis and @BournHallClinic found signs of aging at #centromeres and #kinetochores: https://www.mpibpc.mpg.de/17105301/pr_1928 @CurrentBiology

How do changes at chromosomes of #oocytes promote #aneuploidy when women age? Melina Schuh's team @SchuhLab @MissMeiosis and @BournHallClinic found signs of aging at #centromeres and #kinetochores: https://www.mpibpc.mpg.de/17105301/pr_1928 @CurrentBiology

How do changes at chromosomes of #oocytes promote #aneuploidy when women age? Melina Schuh's team @SchuhLab @MissMeiosis and @BournHallClinic found signs of aging at #centromeres and #kinetochores: https://www.mpibpc.mpg.de/17105301/pr_1928 @CurrentBiology