⭐ #NARBreakthrough ⭐
🧬An endosomal #mRNAtransporter uses teamwork between its 3 RNA recognition motifs (RRMs) to distinguish #accessory from #essential binding sites. Select #cargomRNAs get “VIT” (very important transcript) status for premium transport. 🚚 Read more here: doi.org/10.1093/nar/...

⭐ #NARBreakthrough! ⭐
🧬 New study uncovers how #RNAstructures control stochastic exon selection in Dscam1 genes. #Balancer RNA structures and a #multi-subunit RNA architecture coordinate spatial and temporal splicing 🔬✨
Read the full article here: doi.org/10.1093/nar/...
#AlternativeSplicing

🎉 Congratulations to the first authors, Priyanka Aggarwal and Manmohan Sharma!
Their study in the laboratory of Prof. Karl-Peter Hopfner provides important #mechanistic insight into #chromatin #remodeling across diverse #nucleosomalstates. 🧬🔬 #NARbreakthrough #Chromatin #Epigenetics #INO80

⭐ #NARBreakthrough! ⭐
🔬Using ATAC-seq to measure #chromatin #accessibility, researchers predicted early conditions that would yield successful #differentiation, improve erythroblast production, and identify signals that further boost #efficiency.
@stanna-ccri.bsky.social 📖 doi.org/10.1093/nar/...

⭐NAR Breakthrough! ⭐
🚀 ALE RNA platform overcomes length limits in #chemicaRNAsynthesis, enabling >200-nt RNAs. Supports sgRNAs and 5′-capped mRNAs with strong translation and precise mods. Site-specific 2′-OMe poly(A) boosts protein expression. 🧬Read more: doi.org/10.1093/nar/...
#NARBreakthrough

🔬 #Trypanosomes process their large rRNA in a highly unusual way-by cutting it into six pieces. A new study from @schneian.bsky.social lab identified two essential proteins, TbLrRP1 and TbLrRP2, that drive this process. Read more: doi.org/10.1093/nar/...
#NARBreakthrough #RibosomeBiogenesis

⭐ NAR Breakthrough! ⭐
🔬 New study reveals how the Retron-Eco7 system helps bacteria sense and fight phage attacks, identifying a clever immune-sensing mechanism in the bacteria–phage arms race.
🧬 Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Microbiology #PhageBiology #BacterialDefense

⭐ NAR Breakthrough! ⭐

🔬 New study by Betancurt et al. uses #PacBio single-molecule sequencing to build a long-read fidelity assay that reveals how different #DNApolymerase families make distinct errors.
🧬 Read more: doi.org/10.1093/nar/...
@nebiolabs.bsky.social @pasteur.fr
#NARBreakthrough

⭐ NAR Breakthrough! ⭐
🔬 How do #kinetochores rebuild each #cellcycle?
A new study reveals the order of assembly, hidden interdependencies, and a new regulatory mechanism.
🧬 Read more: academic.oup.com/nar/article/... @suebiggins.bsky.social @fredhutch.org

#NARbreakthrough #ChromosomeSegregation

Disrupted transcriptional networks regulated by CHD1L during neurodevelopment underlie the mirrored neuroanatomical and growth phenotypes of the 1q21.1 copy number variant Abstract. Distal 1q21.1 deletions and duplications are associated with variable phenotypes including autism, head circumference and height defects. To eluc

⭐ NAR Breakthrough! ⭐
New research highlights CHD1L in the chromosome 1q21.1 region—linked to #autism, head size & growth.
🧠 It controls #DNApackaging & genes for #braindevelopment, #cellfate & #connectivity.
Read more: doi.org/10.1093/nar/...
#NARBreakthrough #Neuroscience @igbmc.bsky.social

⭐ #NARBreakthrough in #RNAengineering!⭐
University of Utah @utah.edu chemists show that a single dye can emit two colors with engineered #Broccoli #aptamers (Golden = yellow, Red = red).
They built the first ratiometric biosensor to track #glycine dynamics!
Read more 👉 doi.org/10.1093/nar/...

⭐NAR Breakthrough!⭐

🧬 New study shows Prp22 has a dual role in #splicing—an ATP-independent function that promotes #exonligation by stabilizing Slu7, and an ATP-dependent role that drives Slu7 dissociation + #mRNArelease.
📖 ttps://doi.org/10.1093/nar/gkaf823

#NARBreakthrough #RNA #RNAHelicase

Promoter-targeted small RNA duplexes increase MBNL1 transcription and mitigate myotonic dystrophy-associated spliceopathy Abstract. Functional depletion of Muscleblind-like (MBNL) proteins is a key trigger of myotonic dystrophy (DM)-associated alternative splicing (AltS) defec

⭐NAR Breakthrough!⭐
🧬 New study shows that small activating RNAs can boost MBNL1 expression in #myotonicdystrophy cells, restoring splicing balance. This highlights #RNAactivation (RNAa) as a promising #therapeutic strategy for this #raredisease.
📖 doi.org/10.1093/nar/...
#NARBreakthrough

Capturing a glycosylase reaction intermediate in DNA repair by freeze-trapping of a pH-responsive hOGG1 mutant Abstract. The human 8-oxoguanine DNA glycosylase 1 (hOGG1) is a bifunctional DNA repair enzyme that possesses both glycosylase and AP-lyase activity. Its A

⭐NAR Breakthrough!⭐
🧬 New structure reveals a hidden step in DNA repair.
Researchers captured a hemiaminal-type intermediate of hOGG1, shedding light on its catalytic mechanism.
📖 doi.org/10.1093/nar/...
#NARBreakthrough #DNArepair #StructuralBiology #hOGG1 #Crystallography #Enzymes

Spontaneously directed loop extrusion in SMC complexes emerges from broken detailed balance and anisotropic DNA search Abstract. DNA loop formation by structural maintenance of chromosome (SMC) proteins, including cohesin, condensin, and the SMC5/6 complex, plays a pivotal

⭐NAR Breakthrough!⭐
Bonato et al. propose a model for how the yeast #condensin SMC complex drives persistent #DNAloopextrusion, using #atomicforcemicroscopy and #moleculardynamics.

Read the full article here: doi.org/10.1093/nar/...
#NARBreakthrough #SMC #biophysics #genomefolding #yeast

tRNA modification profiling reveals epitranscriptome regulatory networks in Pseudomonas aeruginosa Abstract. Transfer RNA (tRNA) modifications have emerged as critical post-transcriptional regulators of gene expression affecting diverse biological and di

⭐NAR Breakthrough!⭐
🧬 Sun et al. just dropped a high-throughput method to track all #tRNA #modifications across cells & tissues using #massspec.
Read the full article here: doi.org/10.1093/nar/...
#NARBreakthrough #RNA #tRNA #epitranscriptomics #systemsbiology #therapeuticdiscovery.

⭐NAR Breakthrough!⭐

AlphaFold2 predicted LSI–RDF interactions and experimentally validated several new functional pairs.

@phoeberice.bsky.social @femijohn.bsky.social

doi.org/10.1093/nar/...

#NARBreakthrough #SyntheticBiology #AlphaFold2 #GenomeEditing #ComputationalBiology

📣 New NAR Breakthrough article! 📣

🧬 Cells resist starvation through a nutrient stress splice switch 🧬

👉 Read the free full text here: lnkd.in/eeE8KM8i

#NARBreakthrough #RNAsplicing #YeastGenetics #Introns #Spliceosome

🌟 New NAR Breakthrough article! 🌟

🧬Unexpected enzymatic function of an ancient nucleic acid-binding fold🧬

📖 Read the full text here: lnkd.in/eMxBP9MQ

#NARBreakthrough #MolecularBiology #ProteinSynthesis #TrypanosomaBrucei #ParasiteResearch #OpenAccessPublishing

🚨 New #NARBreakthrough research article from @scaffidilab.bsky.social!

🧬"Systematic Genetic Perturbation Reveals Principles Underpinning Robustness of the Epigenetic Regulatory Network"

#CancerResearch #Epigenetics

👉 Read here: doi.org/10.1093/nar/...