Capturing a glycosylase reaction intermediate in DNA repair by freeze-trapping of a pH-responsive hOGG1 mutant Abstract. The human 8-oxoguanine DNA glycosylase 1 (hOGG1) is a bifunctional DNA repair enzyme that possesses both glycosylase and AP-lyase activity. Its A

⭐NAR Breakthrough!⭐
🧬 New structure reveals a hidden step in DNA repair.
Researchers captured a hemiaminal-type intermediate of hOGG1, shedding light on its catalytic mechanism.
📖 doi.org/10.1093/nar/...
#NARBreakthrough #DNArepair #StructuralBiology #hOGG1 #Crystallography #Enzymes