A new way to make old antibiotics work again | Research Matters A DNA-based strategy from researchers of Indian Institute of Technology, Bombay makes drug-resistant bacteria responsive to antibiotics again.

Precision Engineering: Using DNA to stop bacteria from fighting back

For a deep dive, check out:
researchmatters.in/news/new-way...

#AMR #ScienceInnovation #antibioticresistance #aptamers #scicomm #science #sciencecommunication #IndianScience #ScienceinIndia

Synthetic aptamer mechanoreceptors enable cell-specific force sensing and temporal control via DNA circuits - Nature Communications Engineering synthetic mechanosensing systems with both cell-specificity and programmability remains challenging, especially for classical mechanoreceptors. Here, the authors develop an all-DNA mechano...

Excited to share “Synthetic Aptamer Mechanoreceptors Enable Cell-Specific Force Sensing and Temporal Control via DNA Circuits.” in NatComm. This is our most significant excursion into mechanobiology #mechanobiology #DNAnanoscience #aptamers www.nature.com/articles/s41...

Machine learning-powered aptamer modification—enhancing precision and therapeutic performance
www.scienceopen.com/hosted-docum...
#MachineLearning #Aptamers #Biotherapeutics #MolecularEngineering

Researchers from Sun Yat-sen University and collaborating institutions reported recent advances in aptamer-based wearable electrochemical sensors in a review published in Microsystems & Nanoengineering in 2025.
#sensor #aptamers
Details: doi.org/10.1038/s413...

Client Challenge

New Publication!
Can “off-the-shelf” aptamers work in plasma? Erin Demek shows how proteins and fatty acids disrupt aptamer sensors – and how simple sample prep restores buffer-like sensitivity.

Read more: www.nature.com/articles/s44...

#Biosensors #Aptamers #AnalyticalChemistry

Did you know that we offer more than 100,000 products? We offer more than just #antibodies. Check out antibodies.com to discover our full portfolio, including #aptamers, #AssayKits, tools for #StructuralBiology and #Proteomics, #exosomes, #Nanodiscs, and more!

Covalent aptamers: agents with promising therapeutic and diagnostic potential Small molecule- and antibody-based approaches have shown tremendous success in both therapeutic and diagnostic applications. Aptamers, which are engineered nucleic acid ligands for proteins, have not found similar broad applicability, potentially due to their susceptibility to nuclease-mediated degradation and shor

Very insightful review by the group of Alexander Deiters in @rscchembio.rsc.org. They give an overview of the development of covalent #aptamers for protein labeling and inhibition including an overview of the chemistries used. doi.org/10.1039/d5cb...
#ChemSky #ChemBio #NucleicAcids #RNA #DNA

This review discusses small nucleic acid therapeutics, highlighting advances in chemical modifications and delivery platforms, profiles approved drugs like #AntisenseOligonucleotides, #aptamers, and #siRNAs, and addresses clinical challenges.

#STTT: doi.org/10.1038/s413...

FfAME - Foundation for Applied Molecular Evolution

🚀 Our website just got an upgrade!
Explore our research, meet the team, and see how we’re advancing AEGIS, artificial DNA, and expanding the boundaries of science!

🔬 Check it out → ffame.org


#FfAME #AEGIS #Research #Astrobiology #Aptamers

Aptamer as a therapeutic agent for dengue infections Current treatments for dengue infections face numerous challenges due to the lack of specific antivirals and the diverse nature of the virus, with existing approaches focusing on supportive care.…

Current treatment for #dengue faces numerous challenges due to the lack of specific antivirals and the diverse nature of the virus.

Could #aptamers be utilized as a therapeutic agent against DENV?

👉https://buff.ly/8hbNueC

#IDSky #MedSky

⭐ #NARBreakthrough in #RNAengineering!⭐
University of Utah @utah.edu chemists show that a single dye can emit two colors with engineered #Broccoli #aptamers (Golden = yellow, Red = red).
They built the first ratiometric biosensor to track #glycine dynamics!
Read more 👉 doi.org/10.1093/nar/...

Aptamers, tiny nucleic acid fragments, are revolutionizing bone repair and regeneration, offering precise targeting and minimal side effects!👍
#Aptamers #acid #bone
@brjournal.bsky.social
www.nature.com/articles/s41...

Immune checkpoint inhibitors in cancer therapy: what lies beyond monoclonal antibodies? Alternative strategies such as small-molecule inhibitors, aptamers, bispecific agents, and gene-editing technologies are being explored to overcome the limitations of monoclonal antibody-based immune…

ICIs in #cancer: what lies beyond monoclonal antibodies?

Alternative strategies such as small-molecule inhibitors, #aptamers, gene-editing, and more are being explored to overcome the limitations of monoclonal antibody-based #ICI.

👉https://buff.ly/vtrydPC

#OncSky

Robotic-assisted #capture-SELEX of RNA #aptamers binding to small molecules #ChemBioChem #MayerLab @unibonn.bsky.social; #automation shorturl.at/rTzPm

Ultra-selective aptamers give viruses a taste of their own medicine Inspired by the way viruses attach to cells, EPFL scientists have developed a method for engineering ultra-selective aptamers.

#Aptamers give #viruses a taste of their own medicine ...

| #DNA | #RNA | #antibodies | #nucleicacid | Via @sciencex.bsky.social‬

Original post on mastodon.social

6-Jun-2025
Ultra-selective #aptamers give viruses a taste of their own medicine
Inspired by the way #viruses attach to cells, EPFL scientists have developed a method for engineering ultra-selective aptamers. The synthetic molecules bind to targets like viral spike proteins, making them useful […]

Aptamer-engaged nanotherapeutics against SARS-CoV-2 - Discover Nano The COVID-19 pandemic, caused by the virus SARS-CoV-2 infection, has underscored the critical importance of rapid and accurate therapeutics. The neutralization of SARS-CoV-2 is paramount in controllin...

Aptamer-engaged #nanotherapeutics against #SARS-CoV-2 #DiscoverNano #FamulokLab @unibonn.bsky.social #Aptamers; #COVID-19; #Neutralization shorturl.at/WGHWq

SciTech Chronicles. . . . . . . . .Mar 4th, 2025 With the eyes of a child you must come out see.... Vol II No 57 361 links Curated 2,700-Year-Old Meteorite Jewelry Unearthed in Poland. http...

SciTech Chronicles. . . . . . . . .Mar 4th, 2025

bit.ly/stc030425

#Częstochowa-Mirów #smelting #SEM #metabolites #fatty #acids #1-linoleoyl-GPE #H5N1 #aerosol #electrochemical #aptamers #polyps #colibactin #epithelial #Nissle #Salto #cryovolcanoes

Now online - the Opinion "Small RNA and Toll-like receptor interactions: origins and disease mechanisms" from
@qichen-lab.bsky.social and co.

#sncRNA #TLR #aptamers #RNAtherapeutics #autoimmunediseases

Read it here 👉 authors.elsevier.com/a/1kcgr3S6Gf...

Researchers invent method for rapid metabolite detection using DNA sequencing Researchers at the University of Toronto have invented a new method that uses DNA sequencing to measure metabolites. This enables rapid and precise analysis of biological compounds, such as sugars, vi...

Researchers invent method for rapid #metabolite detection using #DNA #sequencing

#smol-seq #aptamers

phys.org/news/2025-02...

RNA-Puzzles Round V: blind predictions of 23 RNA structures - Nature Methods The results of the Fifth RNA-Puzzles contest highlights advances in RNA three-dimensional structure prediction and uncovers new insights into RNA folding and structure.

"RNA-Puzzles Round V" dives into blind predictions by 18 modeling groups for 23 #RNA structures. 🧬 From #aptamers to #riboswitches, it showcases the progress and challenges in RNA #3D #modeling.

Proud to be part of this journey!

#RNA3D #StructuralBiology #Bioinformatics

🔗 doi.org/10.1038/s415...

Bioprinting of Aptamer‐Based Programmable Bioinks to Modulate Multiscale Microvascular Morphogenesis in 4D Programmable bioinks are developed that dynamically control VEGF presentation by leveraging on aptamer's unique capabilities to specifically capture and release VEGF spatiotemporally within a bioprin....

3D-printed vascular networks use programmable bioink to control blood vessel growth over time.

By combining aptamers and growth factors, the method mimics the body's precision in forming vascular structures.

#vascular #aptamers #biomedicine

onlinelibrary.wiley.com/doi/10.1002/...

DNA Aptamers That Bind to Alginate Hydrogels Hydrogels have become common in wound treatment because they form very stable and biocompatible environments that promote healing. However, due to the highly porous hydrogel structure, any therapeutic added to these gels tends to diffuse quickly and impact delivery to the target site. Aptamers are short, single-stranded DNA or RNA sequences that bind specifically to a target, so aptamers that bind to hydrogels could serve as tags for therapeutics to prevent rapid diffusion and allow for extended delivery. An in vitro selection approach was developed to identify DNA aptamers for alginate hydrogels. Two DNA aptamers were shown to bind hydrogels ranging from 0.5 to 2% alginate and could be either encapsulated during gelation or introduced to preformed gels. Both aptamers also showed specificity for binding to alginate compared to agarose. To demonstrate the functional aspect of the aptamers as tethers for other biomolecules, both aptamers were conjugated to BSA. Aptamer-conjugated BSA was retained longer in the hydrogel during week-long diffusion studies both when encapsulated or introduced to preformed gels, which adds flexibility to how these aptamers can be deployed in a clinical setting.

What better way to introduce ourselves here than to share our newest paper! Congrats to Ali! #aptamers
pubs.acs.org/doi/full/10....

De novo design and optimization of aptamers with AptaDiff bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

Preprint for AptaDiff and short explainer on #Aptamers www.biorxiv.org/content/10.1...