The guy who 1st used phenol to purify DNA deserved a Nobel prize

#DNA #Biology #NucleicAcids #RNA #basepairing #DoubleHelix

This structure of a tRNA acceptor-stem mimic demonstrates the use of bromine and phosphorus anomalous scattering for RNA structure determination #Crystallography #AnomalousScattering #NucleicAcids doi.org/10.1107/S205...

Minor groove tetrads: a potent and versatile capping interaction for i-motif structures - Biophysical Reviews Minor groove tetrads (MGTs) have emerged as powerful structural elements capable of enhancing the stability and versatility of i-motif DNA structures. These non-canonical tetrads, formed by the minor ...

👏Well done!
Huge kudos to M. Garavís, Bartomeu Mir, I. Serrano, C. Cabrero, C. Ugedo, I. Gómez, N. Escaja & C. González for this outstanding work:

doi.org/10.1007/s125...

#DNAnanotech #iMotif #StructuralBiology #DNAresearch #Biotechnology #NucleicAcids #Biosensing

Using structured libraries, selection, and machine learning to rapidly explore the sequence space of a fluorescent deoxyribozyme Abstract. Finding ways to more comprehensively explore the sequence space of complex functional motifs is an important and unresolved question in nucleic a

#research #machinelearning #nucleicacids

Using structured libraries, selection, and machine learning to rapidly explore the sequence space of a fluorescent deoxyribozyme
(Kurfürst, Volek, Samusevich, Pluskal, Curtis)–NAR: doi.org/10.1093/nar/...

@iocbprague.bsky.social @czechacademy.bsky.social

🧬 A new paper from the group of Ed Curtis at IOCB Prague in collab with the @pluskal-lab.org introduces a structure-guided way to explore nucleic acid sequence space that goes beyond traditional random mutagenesis.

#research #machinelearning #nucleicacids #chemistry
1/3

Covalent aptamers: agents with promising therapeutic and diagnostic potential Small molecule- and antibody-based approaches have shown tremendous success in both therapeutic and diagnostic applications. Aptamers, which are engineered nucleic acid ligands for proteins, have not found similar broad applicability, potentially due to their susceptibility to nuclease-mediated degradation and shor

Very insightful review by the group of Alexander Deiters in @rscchembio.rsc.org. They give an overview of the development of covalent #aptamers for protein labeling and inhibition including an overview of the chemistries used. doi.org/10.1039/d5cb...
#ChemSky #ChemBio #NucleicAcids #RNA #DNA

Biophysical and biological properties of splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages Abstract. Antisense oligonucleotides hold great promise in the treatment of disease, but their efficacy is limited by modest bioavailability and toxicity.

Glad to share our new paper online! Splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages academic.oup.com/nar/article/...
#RNAtherapeutics #Oligonucleotides #SpliceSwitching #Phosphorothioate #NucleicAcids

A DNA Scaffold Approach Facilitates 5′ Labeling of the SARS‐CoV‐2 RNA Pseudoknot for Single‐Molecule Förster Resonance Energy Transfer Investigation DNA scaffold-based labeling strategy is introduced that enables single-molecule Förster resonance energy transfer (smFRET) studies of the SARS-CoV-2 frameshifting pseudoknot. The smFRET measurements ...

Curious about new routes for labelling often complicated RNAs for single-molecule FRET studies? You'll want to check out Graham et al.'s recently published work in ChemPhysChem (congratulations 🥳) - buff.ly/SkaruHO
#rna #rnaresearch #virology #singlemolecule #smfret #nucleicacids

Differential stability and dynamics of DNA-based and RNA-based coacervates affect non-enzymatic RNA chemistry - Nature Communications Mixtures of peptides and nucleic acids tend to demix and form coacervate droplets. Here, the authors show that even short peptides and oligonucleotides form droplets. DNA and RNA impart different prop...

She also talked about the formation of coacervates based on #DNA or #RNA as well as #peptides and their potential involvement in early life. (2/2) www.nature.com/articles/s41...

#ChemSky #OriginOfLife #lipid #membrane #evolution #LipidTime #NucleicAcids

Thrilled to receive the 2026 Melanie O’Neill New Investigator Award in Biological Chemistry. Grateful for the phenomenal students, postdocs, collaborators and mentors who power every discovery in our lab! Onward with more nucleic acid chemistry, gene activation and biosensing!!! #NucleicAcids

Excited to host all members of @mechanism-network.bsky.social for a full week of science 🧬 and networking 🤝 in Cologne! Great kickoff with Fredrik Westerlund introducing the MeChaNiSM MSCA DN🎓 Looking forward to a week full of #nucleicacids ideas 💡
@unicologne.bsky.social @wilhelmssonlab.bsky.social

Nucleic acids as key to a new class of drugs In our "EXplained" video series, we present the seven Clusters of Excellence with which our university is entering the next funding phase of the Excellence Strategy. In the second episode, we get to k...

In the second episode of our new EXplained series, we highlight the #ClusterofExcellence NUCLEATE. At our #university, it is represented by Stefan Engelhardt, who shares insights into #nucleid-based #medicine: go.tum.de/139582

#nucleicacids
@lmumuenchen.bsky.social @uni-wuerzburg.de

📷 ProLehre

Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET Abstract. The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has resulted in significant global mortality, with over 7 million cases reported. Despite

🤔 How did Groves et al. use the FLEX to reveal insights about SARS-CoV-2’s RNA polymerase? Find out here > doi.org/10.1093/nar/...

Want to know more about the FLEX? Learn more, request a tech spec or book a demo on our website: excitinginstruments.com/ei-flex/?utm... #smfret #RNA #nucleicacids

Site-Directed Spin Labeling with the Bis-Nitroxide AsymPol Enables Targeted DNP MAS NMR of RNA Dynamic nuclear polarization (DNP) enhances NMR sensitivity by transferring electron spin polarization to nuclei, providing structural and biophysical insights into complex biomolecules at low concentrations. However, conventional DNP often lacks selectivity, amplifying background signals, e.g. in complex environments such as cells. Here, we introduce the bis-nitroxide AsymPol-NCS-SDSL as the first polarizing agent for site-directed spin labeling of RNA to achieve targeted DNP signal enhancement. This AsymPol derivative was conjugated to several sites in sirtuin1 mRNA (mSirt1), which is targeted by microRNA 34a (miR-34a), both regulators of the cancer gatekeeper protein p53. At 9.4 T, enhancements of up to 27-fold were obtained when AsymPol-labeled mSirt1 was paired with 13C,15N-cytidine-labeled miR-34a. Control over polarization localization was achieved by adjusting the deuteration level of the matrix. The resulting long polarization build-up times (TB,on), due to both deuteration and the low biradical concentration, were reduced by doping the sample with the paramagnetic metal ions CuII and GdIII, while maintaining the sensitivity. Together, these results establish a versatile strategy for nitroxide biradical-based targeted DNP in nucleic acids, paving the way for high-sensitivity RNA studies at concentrations ≤ 40 µM, even in cellular environments.

have you ever worried about your DNP MAS #solid-stateNMR experiments on #nucleicacids being too sensitive? well my colleagues have, so they used site-directed spin labelling to link a DNP-active biradical to RNA, which allows enhancement of the RNA but not pesky background signals!
🔗: bit.ly/4nmAl2K

NGS, qPCR, or Sanger Sequencing: An Assay Selection Guide Choose the best assay for your genomics or transcriptomics project using our interactive selection tool and summary of NGS, qPCR, and Sanger methods.

Having difficulty determining which approach is best for your analysis of #NucleicAcids? Our comprehensive #blog and interactive assay selection #guide will help you make your decision: hubs.ly/Q03sxJDp0

#qPCR #NGS #Sanger

Der CDMO-Markt für Nukleinsäuretherapeutika soll bis 2034 ein Volumen von 25,49 Milliarden US-Dollar erreichen und eine gesunde jährliche Wachstumsrate von 12,27 % aufweisen. - ekz-crosstour Marktübersicht für Nukleinsäure‑Therapeutika-CDMOs:Marktforschungsbericht zum Markt für CDMO-Dienstleistungen rund um Nukleinsäure-Therapeutika nach Molekültyp (mRNA, siRNA, ASO, CRISPR/Cas, Plasmid-D...

CDMO für Nukleinsäuretherapeutika
🧬🏭 CDMO-Markt steigt auf $25.49 Mrd. bis 2034 📈 +12.27% CAGR 🚀
#PharmaManufacturing #NucleicAcids #BioTech

ekz-crosstour.ch/2025/07/17/d...

Two fantastic talks from the #nucleicAcids world at today's @biochemsoc.bsky.social SM@SH seminar! Great to welcome Askash Basu from Durham to hear about bendability in #DNA sequences and beautiful cryoEM from Anamika Kumari Lahiri Lab in the ECR talk slot! 🧬🧬🧬👏@sheffielduni.bsky.social

Meet Prof. Ramón Eritja, Leader of the Oligonucleotide Synthesis Platform
Want to learn more about this renowned expert?
Visit👉 www.nanbiosis.es/ramon-eritja/

#ICTSnews #NanbiosisExpertise #CEbiomedS #CEBS #Biotechnology #Genomics #MolecularBiology #LifeSciences #NucleicAcids #BiomedicalResearch

Automating DNA/RNA extraction from FFPE, ccfDNA & blood isn’t easy. Join our live expert forum to get practical tips for optimizing complex workflows on liquid handlers. Ask your toughest questions! event.on24.com/wcc/r/497083...

#LabAutomation #NucleicAcids #Oncology

“We are witnessing a revolution in nucleic acid research” Stefan Engelhardt is one of three spokespeople of the new Cluster of Excellence NUCLEATE. In this interview he explains the importance of nucleic acid research.

Read the interview with Stefan Engelhardt, our Professor of #Pharmacology and #Toxicology, who talks about the new #ClusterofExcellence, #NUCLEATE, which explores the function and regulation of #nucleicacids: go.tum.de/705241 🧬

#RNA #DNA
@lmumuenchen.bsky.social @uni-wuerzburg.de

📷A. Heddergott

Lynn Zechiedrich BCM

We are pleased to welcome Professor Lynn Zechiedrich (Baylor College of Medicine), a leading expert in DNA topology, supercoiling & topoisomerases, to our JBSD Editorial Board. #JBSD #DNATopology #Topoisomerase #NucleicAcids www.bcm.edu/people-searc...

What’s the most exciting or influential nucleic acids research you’ve come across? Share it with us! 👇 #NationalDNADay #NucleicAcids #Genomics #DNAday2025 #MolecularBiology #Research #DNA #RNA #Epigenetics

🧬 Happy National DNA Day! 🧬
Today we celebrate the completion of the human genome project (2003) and discovery of the double helix (1953). From genome editing to RNA therapeutics, research into nucleic acids continues to drive scientific breakthroughs #NationalDNADay #NucleicAcids #DNAday2025

Exciting times at JBSD as we refresh our Editorial Board! We are pleased that Dr. Elena Bichenkova (Univ. of Manchester), a leader in nucleic acid structure & dynamics, is continuing with us. More announcements to come! #JBSD #StructuralBiology #NucleicAcids

Molecular Therapy Nucleic Acids welcome your submissions of original research articles and reviews.

Molecular Therapy Nucleic Acids welcomes your submissions of original research articles and reviews focused on nucleic acid-based therapeutics to treat and/or correct genetic and acquired disease. Submit your paper today: http://dlvr.it/TK4qg7
#MolecularTherapy #NucleicAcids

#MolecularTherapy Nucleic Acids is the top journal for research and cutting-edge reviews focused on #NucleicAcids, #GeneEditing, #Biotechnology, and more. Learn more about MTNA and submit your research today: bit.ly/4lj850B

In the montage here we have a #SuperResolution #SMLM image of #PanLNP in magenta and #ligand in yellow, and a diffraction-limited image of #NucleicAcids in cyan. When overlayed together, scientists can immediately see what fraction of their LNPs actually carry both RNA cargo and targeting ligand.

RNA Cytoskeletons & AI-Driven Synthetic Biology: New Frontiers! Cutting-edge RNA research explores synthetic biology's frontier, unveiling groundbreaking strategies for constructing artificial cells and understanding cellular building blocks.

New issue is out! 🎉 Creating artificial cells is synthetic biology's boldest goal, and today is a step closer, thanks to RNA origami! Amazing work from @zmbh.uni-heidelberg.de and @mpi-mr.bsky.social 😎🧪🖥️🧬 #biotech #RNA #synbio #nucleicacids Subscribe at 👉 plentyofroom.beehiiv.com/p/rna-skelet...

Nucleic Acid "Assembly"

DNA & RNA are vital for life, carrying genetic info. DNA, as a double helix, stores it, while RNA translates it to proteins. DNA's stability ensures accurate replication, RNA's versatility aids gene expression.

Made in Blender.

#molecules #nucleicacids #blender #molbio

Overlooked alarm signal: RNA damage moves into the spotlight Because RNA is relatively short lived, RNA damage was long dismissed as not that significant. In our interview, biochemist Julian Stingele explains why this view has changed.

➡️RNA damage⬅️ was long dismissed as not that significant. In an interview, Julian Stingele explains why this view has changed:
www.lmu.de/en/newsroom/...
#RNA #NucleicAcids @lmumuenchen.bsky.social @jstingele.bsky.social