https://www.cell.com/cell/fulltext/S0092-8674(25)01502-8 No description available

PDA cells modulate autophagy via ECM sensing through the α3 integrin-Hippo-YAP1 axis, highlighting a novel pathway in tumor heterogeneity regulation. PMID:41702399, Cell 2026, @Cell www.cell.com/cell/fulltext/S0092-8674... #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

#Ryugu #asteroid #samples contain all #DNA and #RNA #building #blocks, bolstering #origin-of-life #theories

The nucleobase presence indicates primitive asteroids could produce and preserve molecules that are important for origin-of-life chemistry scitechupdates.com/r...

https://doi.org/10.1093/nar/gkag260 No description available

Discover how 7 DNA repair patterns guide CRISPR outcomes! Dive into genome-wide networks with indel pattern-guided insights. PMID:41891877, Nucleic Acids Res 2026, @NAR_Open @OTSociety @NAR_Open https://doi.org/10.1093/nar/gkag260 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Hot off the press from the RTI: Efficient Downregulation of Flt-1 Mediated by Splice Switching ASO in Murine Endothelial Cells

buff.ly/UtkzwT5 #RNA #RNATherapeutics @UMassChan

Efficient Downregulation of Flt-1 Mediated by Splice Switching ASO in Murine Endothelial Cells - PubMed Impaired angiogenesis is a common feature of several pathological conditions, including neuromuscular disorders. Such vascular defects not only contribute to disease progression but also may compromise...

Hot off the press from the RTI: Efficient Downregulation of Flt-1 Mediated by Splice Switching ASO in Murine Endothelial Cells
pubmed.ncbi.nlm.nih.gov/41933450/?ut... #RNA #RNATherapeutics

https://doi.org/10.1001/jamapsychiatry.2026.0246 No description available

Delve into ethical dilemmas of RDD trials for stopping opioid use disorder meds. Key insights from JAMA Psychiatry. PMID:41848706, JAMA Psychiatry 2026, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2026.0246 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1093/nar/gkag167 No description available

CRISPR-Cas12a activity enhanced! Reversible crRNA scaffold remodeling via short DNA blockers boosts precision and control. PMID:41784267, Nucleic Acids Res 2026, @NAR_Open @OTSociety @NAR_Open https://doi.org/10.1093/nar/gkag167 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1038/s41586-026-10224-0 No description available

Detect disease origins and therapy responses from just 50μl of plasma with cf-EpiTracing! Profiles histone mods, integrates chromatin states, uses AI. PMID:41781618, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10224-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Quality-oriented diet therapy for chronic kidney disease | Nature Reviews Nephrology Traditional dietary advice for people living with chronic kidney disease (CKD) focused predominantly on the quantity of energy and protein provided by the diet as well as restricting the consumption of single micronutrients. However, flaws in the assumptions that underlie this quantity-based approach have led to re-examination of medical nutrition therapy for kidney-related conditions, with a shift towards recommending more varied and liberalized plant-rich diets with a focus on dietary quality. Although clinical practice guidelines for patients with CKD have cautiously acknowledged this shift, less advice is available on how to translate new knowledge into practical and feasible recommendations that describe which foods patients should be advised to eat. In this Review, we provide a framework for the delivery of quality-oriented diet therapy for people with CKD based on the dietary principles of balance, variety and moderation. This approach also requires consideration of the manner i

Revised CKD diet therapy: Move from rigid nutrient limits to diverse, plant-rich focus for improved nutrition quality! PMID:41491876, Nat Rev Nephrol 2026, @NatRevNeph https://doi.org/10.1038/s41581-025-01034-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Health of adipose tissue: oestrogen matters | Nature Reviews Endocrinology Menopausal women are more likely than premenopausal women to gain weight in the form of excess adipose tissue, which becomes preferentially deposited in the viscera. This body composition shift, largely driven by declining oestrogen levels, increases cardiometabolic disease risk. Oestrogens are key hormones involved in many metabolic processes, including in adipose tissue. Given the strong influence that adipose tissue health has on systemic metabolism, additional insights into mechanisms by which oestrogens affect adipose tissue phenotype and function are critical. Not only is adipose tissue affected by oestrogen signalling, adipose tissue is also a major source of circulating oestrogens, and the only appreciable source of oestrogens for men and postmenopausal women. Therefore, women with obesity have higher circulating levels of oestrogens, but whether this fact contributes to the diverse comorbidities of obesity (such as, cancer, metabolic syndrome and osteoporosis) remains unclear.

Menopause ups visceral fat, often due to lower oestrogen, raising cardiometabolic risk in women. Insights needed! PMID:41006902, Nat Rev Endocrinol 2026, @NatureRevEndo https://doi.org/10.1038/s41574-025-01180-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Early bird registration is ENDS TODAY for our 8th annual #RNA Therapeutics: From Concept to Clinic, June 24–26, 2026 @umasschan.bsky.social‬ #RNATx2026 buff.ly/vi22rN6

https://doi.org/10.1056/NEJMoa2509807 No description available

Prime Editing corrects delGT in NCF1 for p47^phox-deficient CGD. Two participants received stem-cell therapy PM359 with busulfan prep. PMID:41358590, N Engl J Med 2026, @NEJM https://doi.org/10.1056/NEJMoa2509807 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Programmable macromolecule delivery via engineered trogocytosis | Nature Cell Biology Trogocytosis, the transfer of plasma membrane fragments during cell–cell contact, offers potential for macromolecular delivery but is limited by the uncertain fate of trogocytosed molecules, restriction to membrane cargo and unclear generalizability. Here we demonstrate that donor cells engineered with designed receptors specific to surface ligands can transfer proteins to recipient cells through direct contact. We identified key engineering principles for enhancing transfer and ensuring cargo functionalization, including receptor design, pH-responsive membrane fusion, inducible cargo localization and release, and subcellular translocation. The method is broadly applicable across diverse cell types and operates through a dynamin- and endosome acidification-dependent pathway. Exploiting these findings, we developed TRANSFER, a versatile delivery system with programmable cell type specificity and tunability. TRANSFER can sense multiple ligand inputs, deliver large therapeutic protein car

New tech for macromolecule transfer: Engineered receptors enable direct protein delivery between cells via trogocytosis! #BiotechRevolution PMID:41922519, Nat Cell Biol 2026, @NatureCellBio @Stanford https://doi.org/10.1038/s41556-026-01920-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

DPEP2 suppresses hyperinflammation via metabolic reprogramming of macrophages in sepsis | Nature Communications Sepsis-induced excessive inflammation contributes to mortality, but restricting hyperinflammation in sepsis remains challenging. Here, we identify dipeptidase 2 (DPEP2) as an immunotherapeutic target in sepsis by integrating single-cell and bulk RNA sequencing data from septic patients. In patients with sepsis, peripheral monocytes/macrophages have reduced DPEP2 expression, with DPEP2 levels negatively correlating with inflammation severity, disease progression, and clinical outcomes. In vitro, Dpep2 knockdown enhances macrophage-mediated inflammation, while in septic mice in vivo, macrophage-specific Dpep2 loss decreases survival by exacerbating inflammation and organ damage. Mechanistically, sepsis-induced EGR1 represses Dpep2 transcription, leading to reduced DPEP2-mediated enzymatic cleavage of leukotriene D4 (LTD4). Increased LTD4 redirects the metabolic flux toward prostaglandin E2 overproduction, amplifying NF-κB activation and lipopolysaccharide-induced inflammatory cytokine pr

DPEP2 cuts sepsis death risk, regulating inflammation via macrophage metabolism. Reduced DPEP2 in sepsis correlates with severe inflammation and outcomes. PMID:41803155, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-70466-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1001/jamaneurol.2025.5493 No description available

Glucocorticoids in the ED for migraine may pose risks; not advised as first-line for adults or kids. Use with caution! PMID:41661582, JAMA Neurol 2026, @JAMANeuro https://doi.org/10.1001/jamaneurol.2025.5493 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Beautiful work showing the power of #smFRET for uncovering the complexities ensembles in biology, this time for #RNA structures during transcription- congratulations @olivierduss.bsky.social !!

Small-molecule binding and sensing with a designed protein family | Nature Communications The de novo design of small-molecule–binding proteins holds great promise as a potential tool to develop sensors on-demand for arbitrary small molecules. Here we combine deep learning and physics-based methods to generate a family of proteins with diverse and designable pocket geometries, which we employ to computationally design binders for six small-molecule targets. Biophysical characterization of the designed binders reveals nanomolar to low micromolar binding affinities and atomic-level design accuracy. Additionally, we use a cortisol binder to design a chemically induced dimerization (CID) system that enables the construction of a biosensor for cortisol detection. The approach described here demonstrates the potential of the NTF2 fold and deep learning-based protein design in sensor development, paving the way for future platforms to design binders and sensors for small molecules across analytical, environmental, and biomedical applications. Computationally designing proteins wit

Discover how a new protein family, designed via deep learning and physics methods, achieves nanomolar to low micromolar affinities for 6 small molecules! PMID:41904144, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-70953-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

NANP targeting radiosensitizes glioblastoma through TNFR1 sialylation-driven mesenchymal shift | Nature Communications Glioblastoma (GBM) patients have dismal survival due to resistance to initial ionizing radiation therapy (RT). Clonal evolution analysis reveals no dominant RT-resistant clones, prompting a genome-wide CRISPR screen to identify radiosensitizing targets. The screening highlights DNA damage response genes, validating the effectiveness of our approach. N-acylneuraminate-9-phosphatase (NANP), a critical enzyme in the sialic acid synthetic pathway, is top-ranked in the screening and associated with patient outcomes. After radiation, NANP-deficient cells exhibit more DNA damage, G2/M arrest and apoptosis, and impaired DNA repair by favoring non-homologous end-joining over homologous recombination. Mechanistically, NANP influences NF-κB signaling and the mesenchymal state by modulating sialylation and internalization of tumor necrosis factor receptor 1 (TNFR1), thereby affecting RT sensitivity. Intracranial orthotopic xenograft experiments validate the function of NANP in vivo. Here, we ident

A study finds NANP inhibition radiosensitizes glioblastoma by a TNFR1-driven mesenchymal shift, potentially improving GBM therapy. PMID:41851195, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-70853-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Magnetic resonance microscopy maps widespread effects of Alzheimer’s disease on brain structures and behavior in mice | Nature Neuroscience Alzheimer’s disease has widespread effects on brain structure, function and behavior, but we lack a systematic dissection of its impact across hundreds of forebrain and brainstem regions. Here, using diffusion tensor MRI at 25 µm, we mapped the global consequences of mutations in APP and PSEN1 across 231 regions of interest (ROIs) in male and female 5×FAD BXD hybrid mice at 14 months. Over half of the ROIs change in volume along rostrocaudal and mediolateral axes of the CNS, with unexpected swelling in the neocortex, hippocampus and amygdala of up to 10%, counterbalanced by shrinkage in the thalamus, brainstem and most white matter tracts. Yet, total brain volume is unaltered. Variation in individual ROI volumes is highest in females. Differences in fear acquisition and contextual memory performance covary with volumes of several regions and can have opposite polarities between cases and controls. These structural benchmarks establish a foundation for testing therapeutic interventions

Alzheimer's mutations in APP/PSEN1 alter over 50% of 231 brain regions in 5×FAD BXD mice. Detailed MRI maps reveal vast changes at 25μm. PMID:41748785, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-025-02199-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1038/s41581-025-01038-w No description available

Chronic kidney disease affects ~10% globally, challenging the single-cause approach. Reassessing kidney capacity-workload balance is key. PMID:41491877, Nat Rev Nephrol 2026, @NatRevNeph https://doi.org/10.1038/s41581-025-01038-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

ROCKET Launches Structural Biology Past AlphaFold - Harvard University - Department of Molecular & Cellular Biology Five years ago, a team at Google’s DeepMind won CASP14, the long-running protein structure prediction competition, with AlphaFold, a machine-learning system capable of predicting the three-dimensional...

ROCKET Launches Structural Biology Past AlphaFold 🧪 🧬 #AcademicSky #higherEd #RNA #Protein
www.mcb.harvard.edu/department/n... @hekstralab.bsky.social @cam.ac.uk @flatironinstitute.org @umeauniversitet.bsky.social@tcddublin.bsky.social @stjuderesearch.bsky.social @columbiauniversity.bsky.social

New Studies Reveal How DNA Motion and Cell Mechanics Drive Cancer Multiple recent findings show that the physical behavior of DNA and internal cell currents play larger roles in cancer than previously understood.

New Studies Reveal How DNA Motion and Cell Mechanics Drive Cancer

ground.news/article/new-...

#science #forschung #cell #rna #dna #cancer #krebs

https://doi.org/10.1093/nar/gkag172 No description available

CRISPR/Cas9 screening unveils PABPN1 at APA's core. A dBFPR strategy spots APA regulators, boosting detection efficiency. PMID:41755634, Nucleic Acids Res 2026, @NAR_Open @OTSociety @NAR_Open https://doi.org/10.1093/nar/gkag172 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1001/jamadermatol.2026.0019 No description available

Woman, 60s, with 3-year pulmonary hypertension, 2-month dyspnea, and abdominal distension. Possible diagnosis? Let's discuss! 🎯 PMID:41879764, JAMA Dermatol 2026 https://doi.org/10.1001/jamadermatol.2026.0019 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Heart attack damage reversed with injectable RNA therapy, study finds - Replaye Columbia University scientists developed a two-step RNA therapy that may repair cardiovascular tissue after a heart attack by turning muscles into a "healing protein factory."

Heart attack damage reversed with injectable RNA therapy, study finds
replaye.com/heart-attack...

#News #HeartAttack #RNA #Study #Health

🔗 In Silico Analysis of Potential Stabilizer Binding Sites at Protein–RNA Interfaces. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0016 📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

🔗 In Silico Analysis of Potential Stabilizer Binding Sites at Protein–RNA Interfaces. doi.org/10.34133/csb...

📚 CSBJ - A Science Partner Journal: spj.science.org/journal/csbj

@tum.de @ethz.ch #StructuralBiology #DrugDiscovery #ComputationalBiology #RNA #MolecularBiology #Bioinformatics #DrugDesign

Results are in for @stanfordmedicine.bsky.social Kaggle #RNA 3D Folding, Part 2! Top teams team_cp and AyPy together just outperform the best template oracle, another milestone in computational biology. Come join the conversation as we prepare for #CASP17: www.kaggle.com/c/stanford-r...

Hot off the press from the RTI: Testis-specific lncRNA Teshl regulates acrosome biogenesis to maintain sperm structure and function

buff.ly/djTfcMt #RNA #RNATherapeutics @UMassChan

We are thrilled to share our latest work uncovering a completely novel pathway in plants, where Pol II elongation factor SPT6L recruits AGO4 to guide mRNA methylation 🌿🔬
www.biorxiv.org/content/10.6...
#PlantSci #Epigenetics #RNA #Preprint #epitranscriptomics

Exclusive: First clinical trial of tRNA therapy, a new disease-agnostic form of genetic medicine, will start soon Alltrna receives clearance for the first clinical trial of a tRNA-based therapy that could one day be used to treat multiple genetic diseases, starting with tests in Australia. The company raised $109...

A new form of #RNA medicine where a single therapy could potentially be reused across many different diseases is heading into the clinic.

@alltrna.bsky.social just got clearance to start the first trial of a #tRNA therapy

Read more in my exclusive for @endpts.com: endpoints.news/first-clinic...