Programmable macromolecule delivery via engineered trogocytosis | Nature Cell Biology Trogocytosis, the transfer of plasma membrane fragments during cell–cell contact, offers potential for macromolecular delivery but is limited by the uncertain fate of trogocytosed molecules, restriction to membrane cargo and unclear generalizability. Here we demonstrate that donor cells engineered with designed receptors specific to surface ligands can transfer proteins to recipient cells through direct contact. We identified key engineering principles for enhancing transfer and ensuring cargo functionalization, including receptor design, pH-responsive membrane fusion, inducible cargo localization and release, and subcellular translocation. The method is broadly applicable across diverse cell types and operates through a dynamin- and endosome acidification-dependent pathway. Exploiting these findings, we developed TRANSFER, a versatile delivery system with programmable cell type specificity and tunability. TRANSFER can sense multiple ligand inputs, deliver large therapeutic protein car

New tech for macromolecule transfer: Engineered receptors enable direct protein delivery between cells via trogocytosis! #BiotechRevolution PMID:41922519, Nat Cell Biol 2026, @NatureCellBio @Stanford https://doi.org/10.1038/s41556-026-01920-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

China's Hemophilia A Gene Therapy Partnership That Could Change Everything - AktieGo Belief BioMed and Grand Life Sciences partner to bring BBM-H803 gene therapy to 30,000 hemophilia A patients in China. Here's what it means for treatment access.

From lifelong injections to potential one-time cure?
This China hemophilia A gene therapy partnership is shaking up biotech. Could this be the breakthrough patients have been waiting for?
👉 aktiego.com/sectors/biot...
#GeneTherapy #BiotechRevolution #LifeSciences #HealthTech

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. Imagine smart pills that track digestion or medication adherence, sending data straight to your doctor! 🏥💡 This seamless blend of biotech and digital connectivity is revolutionizing healthcare—less invasive, more personalized, and paving the way for a future where our bodies and devices work […]

Agricultural Biotechnology Market Size, Growth Outlook 2032 Agricultural Biotechnology Market growth register a 8.90% CAGR By 2032. Agricultural Biotechnology industry trends By Crop Type, Application, Techniques, top players analysis, regions- forecast 2032.

🌱 Farming goes high-tech! Agri-biotech innovations are reshaping crop yield, sustainability & global food security. #AgriTech #BiotechRevolution #SustainableFarming #FoodTech

www.marketresearchfuture.com/reports/agri...

Longevity.Technology CEO Phil Newman on the longevity industry’s evolution and why Longevity 3.0 might not be as far off as it sounds.

longevity.technology/news/were-al...

#Longevity #FutureOfHealth #BioTechRevolution #AgingInnovation #Longevity3_0 #TechMeetsHealth #AgeReversal

Breaking News: Biotech Skincare Revolutionizes Aging Skins! 🌟🔬 New tech targets genetic markers to restore youthful glow without surgery. #SkincareTech #BiotechRevolution #YouthfulSkin Gifst 4 friends: cutt.ly/mrRsbc36

Scientists Launch Wild New Project to Build a Human Genome From Scratch The medical charity behind the controversial new plan says the benefits outweigh the risks.

Writing Life: Inside the Bold Synthetic Human Genome Project

#SyntheticBiology #HumanGenome #SynHG #GizmodoScience #GenomeSynthesis #Bioethics #BiotechRevolution

gizmodo.com/scientists-l...

"Revolutionizing skincare with biotech: precision-engineered formulas harnessing the power of science for healthier, glowing skin. Say goodbye to guesswork—biotech is changing the game! 🌿✨ #SkinHealth #BiotechRevolution #Wellness" Cheap & High Quality Makeup: cutt.ly/FrRrWxtI

Swedish scientists have created tiny nanorobots from amino acids that can precisely kill cancer cells without harming healthy ones.

#CancerBreakthrough #Nanorobots #MedicalInnovation #SwedenScience #FutureOfMedicine #DNATech #BiotechRevolution

https://doi.org/10.1126/science.add8468 No description available

Synthetic protein circuit mimics neural network in cells! Uses de novo proteins & viral proteases for advanced computation. #BiotechRevolution PMID:39666795, Science 2024, @ScienceMagazine https://doi.org/10.1126/science.add8468 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

https://doi.org/10.1126/science.adt9921 No description available

Synthetic gene circuits engineer T cells to treat brain & inflammatory diseases. Innovative, targeted therapy! #BiotechRevolution PMID:39637005, Science 2024, @ScienceMagazine https://doi.org/10.1126/science.adt9921 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

a man is pouring red liquid into a pitcher with a smiley face on it and the word me written on it ALT: a man is pouring red liquid into a pitcher with a smiley face on it and the word me written on it

The biotech revolution has begun. We will be seeing more technology that works with our receptors to help us modulate our bodies more directly. The future is here. GLP-1s just burst through like the kool-aid man. Fill my cup! #biotechrevolution #GLP-1

Organelle-like structural evolution of coacervate droplets induced by photopolymerization | Nature Communications The dynamic study of coacervates in vitro contributes our understanding of phase separation mechanisms in cells due to complex intracellular physiology. However, current researches mainly involve the use of exogenous auxiliary agents to form multi-compartmental coacervates with short-term stability. Herein, we report the endogenous self-organizing of multi-component coacervates (HA/PDDA/BSA/DMAEMA) induced by a dynamic stimulation process of protein-mediated photopolymerization. As polymerization proceeds, the cycled structural evolution and maturation from coacervate droplets into multi-compartmental coacervates, coacervate vesicles and coacervate droplets are revealed, which are driven by electrostatic interaction and osmotic pressure difference supported by dynamic and thermodynamic control. Specially, by regulating the light stimulation time, a type of multi-compartmental coacervates can be widely obtained with high structural stability over 300 days. Being a promising artificial c

Discover multi-component coacervates evolving into organelle-like structures via protein-mediated photopolymerization! Self-organizing, stable, & dynamic. #BiotechRevolution PMID:39971992, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-57069-1 #Medsky #Pharmsky #RNA 🧪

Substrate interactions guide cyclase engineering and lasso peptide diversification | Nature Chemical Biology Lasso peptides are a diverse class of naturally occurring, highly stable molecules kinetically trapped in a distinctive [1]rotaxane conformation. How the ATP-dependent lasso cyclase constrains a relatively unstructured substrate peptide into a low entropy product has remained a mystery owing to poor enzyme stability and activity in vitro. In this study, we combined substrate tolerance data with structural predictions, bioinformatic analysis, molecular dynamics simulations and mutational scanning to construct a model for the three-dimensional orientation of the substrate peptide in the lasso cyclase active site. Predicted peptide cyclase molecular contacts were validated by rationally engineering multiple, phylogenetically diverse lasso cyclases to accept substrates rejected by the wild-type enzymes. Finally, we demonstrate the utility of lasso cyclase engineering by robustly producing previously inaccessible variants that tightly bind to integrin αvβ8, which is a primary activator of t

Unlocking lasso peptide diversity! 🔓🔄ATP-dependent cyclase engineering is guided by substrate interactions, molecular dynamics & mutational scans. #BiotechRevolution PMID:39261643, Nat Chem Biol 2025, @nchembio https://doi.org/10.1038/s41589-024-01727-w #Medsky #Pharmsky #RNAsky 🧪

Identification and characterization of cell niches in tissue from spatial omics data at single-cell resolution | Nature Communications Deciphering the features, structure, and functions of the cell niche in tissues remains a major challenge. Here, we present scNiche, a computational framework to identify and characterize cell niches from spatial omics data at single-cell resolution. We benchmark scNiche with both simulated and biological datasets, and demonstrate that scNiche can effectively and robustly identify cell niches while outperforming other existing methods. In spatial proteomics data from human triple-negative breast cancer, scNiche reveals the influence of the microenvironment on cellular phenotypes, and further dissects patient-specific niches with distinct cellular compositions or phenotypic characteristics. By analyzing mouse liver spatial transcriptomics data across normal and early-onset liver failure donors, scNiche uncovers disease-specific liver injury niches, and further delineates the niche remodeling from normal liver to liver failure. Overall, scNiche enables decoding the cellular microenvironm

🔬 Exciting breakthrough! The scNiche framework identifies cell niches from spatial omics at single-cell level with unmatched accuracy! #scNiche #BiotechRevolution PMID:39956823, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-57029-9 #Medsky 🧪

https://doi.org/10.1093/nar/gkae1237 No description available

A novel optogenetic toolbox enables blue light-induced transcription deactivation! Engineered compact regulators revolutionize gene expression control. #BiotechRevolution PMID:39676667, Nucleic Acids Res 2025, @NAR_Open @OTSociety https://doi.org/10.1093/nar/gkae1237 #Medsky 🧪

Oral delivery of therapeutic proteins by engineered bacterial type zero secretion system | Nature Communications Genetically engineered commensal bacteria are promising living drugs, however, their therapeutic molecules are frequently confined to their colonization sites. Herein, we report an oral protein delivery technology utilizing an engineered bacterial type zero secretion system (T0SS) via outer membrane vesicles (OMVs). We find that OMVs produced in situ by Escherichia coli Nissle 1917 (EcN) can penetrate the intact gut epithelial barrier to enter the circulation and that epithelial transcytosis involves pinocytosis and dynamin-dependent pathways. EcN is engineered to endogenously load various enzymes into OMVs, and the secreted enzyme-loaded OMVs are able to stably catalyze diverse detoxification reactions against digestive fluid and even enter the circulation. Using hyperuricemic mice and uricase delivery as a demonstration, we demonstrate that the therapeutic efficacy of our engineered EcN with a modified T0SS outperforms that with a direct protein secretion apparatus. The enzyme-loaded

Engineered E. coli Nissle 1917 uses bacterial T0SS for oral protein delivery via OMVs. Crosses gut barrier, enters circulation. #BiotechRevolution PMID:39984501, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-57153-6 #Medsky 🧪

Nanobody-thioesterase chimeras to specifically target protein palmitoylation | Nature Communications The complexity of the cellular proteome is massively expanded by a repertoire of chemically distinct reversible post-translational modifications (PTMs) that control protein localisation, interactions, and function. The temporal and spatial control of these PTMs is central to organism physiology, and mis-regulation of PTMs is a hallmark of many diseases. Here we present an approach to manipulate PTMs on target proteins using nanobodies fused to enzymes that control these PTMs. Anti-GFP nanobodies fused to thioesterases (which depalmitoylate protein cysteines) depalmitoylate GFP tagged substrates. A chemogenetic approach to enhance nanobody affinity for its target enables temporal control of target depalmitoylation. Using a thioesterase fused to a nanobody directed against the Ca(v)1.2 beta subunit we reduce palmitoylation of the Ca(v)1.2 alpha subunit, modifying the channel’s voltage dependence and arrhythmia susceptibility in stem cell derived cardiac myocytes. We conclude that nanobod

Discover targeted protein control: Nanobody-thioesterase chimeras manipulate palmitoylation, enhancing precision. PTM mis-regulation? Not anymore! #BiotechRevolution PMID:39920166, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56716-x #Medsky 🧪

Droplet-supported liquid-liquid lateral phase separation as a step to floating protein heterostructures | Nature Communications Liquid-liquid phase separation plays an important role in many natural and technological processes. Herein, we implement lateral microphase separation at the surface of oil micro-droplets suspended in water to prepare a range of discrete floating protein/polymer continuous two-dimensional (2D) heterostructures with variable interfacial domain structures and dynamics. We show that gel-like domains of bovine serum albumin (BSA) co-exist with fluid-like polyvinyl alcohol (PVA) regions at the oil droplet surface to produce floating heterostructures comprising a 2D phase-separated protein mesh or an array of discrete mobile protein rafts depending on the conditions employed. Enzymes are embedded in the discontinuous BSA domains to produce droplet-supported microphase-separated 2D reaction scaffolds that can be tuned for interfacial catalysis. Taken together, our work has general implications for the structural and functional augmentation of oil droplet interfaces and contributes to the surf

Discover how BSA gels coexist with PVA fluids on oil droplets for dynamic 2D protein/polymer structures! Explore liquid-liquid phase separation in this breakthrough. #BiotechRevolution PMID:39988593, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-57141-w #Medsky 🧪

Revolutionizing Industries with Bacteria from Extreme Environments - SynBioBeta

🌋 Extreme Bacteria Unveiled
Pseudomonas alcaligenes from Chilean hot springs thrives at 44°C, producing substances that enable survival in harsh conditions. 🔬

read more: www.synbiobeta.com/read/revolut...

#ScientificInnovation #BiotechRevolution #ExtremeBacteria #HotSpringDiscovery

Fundraising 🇫🇷 Bioptimus Secures $76M to Advance AI in Biotechnology Bioptimus, an AI startup located in Paris, has successfully raised $76 million in funding. This milestone marks a significant achievement for the company as it continues to develop its artificial intelligence solutions. The funding is expected to propel its growth and innovation in the competitive tech landscape.

Bioptimus secures $76M: Revolutionizing biotechnology with AI 🧬

#Bioptimus #AIInBiology #BiotechRevolution #FundingNews

Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2 - Nature Communications SPNS2 exports S1P and FTY720-P to control immune cell migration. Here, the authors use cryo-EM, immunofluorescence, in vitro binding and in vivo S1P export, and MD simulations to uncover the mechanism...

Discover how SPNS2 transports S1P, pivotal to heart and immunity, and impacts FTY720-P therapy for multiple sclerosis! 🧬🔍 #BiotechRevolution PMID:39820269, Nat Commun 2025, @NatureComms doi.org/10.1038/s414...

#TransformingHealthcare #LifeSavingScience #OncologyResearch #FutureOfMedicine #MedicalBreakthroughs #CellularTherapy #HematologyOncology #ResearchMatters #HopeThroughScience #CuttingEdgeTherapies #ClinicalInnovation #BiotechRevolution #CuringCancer

When cutting-edge tech and biology collide, the line between innovation and accident gets razor-thin. Today's tumor transplant is tomorrow's hostile takeover—inside your DNA. #BioWeaponry #CorpoWars #BiotechRevolution

#CureCancer #AdvancedTherapies #Biopharma #PrecisionMedicine #CheckpointInhibitors #TCellTherapy #SolidTumorTherapy #HematologicCancers #StemCellResearch #CancerTreatment #TumorTargeting #TranslationalResearch #BiotechRevolution #ImmunoOncology #FutureOfMedicine #BreakthroughScience

#CureCancer #AdvancedTherapies #Biopharma #PrecisionMedicine #CheckpointInhibitors #TCellTherapy #SolidTumorTherapy #HematologicCancers #StemCellResearch #CancerTreatment #TumorTargeting #TranslationalResearch #BiotechRevolution #ImmunoOncology #FutureOfMedicine #BreakthroughScience

Combining AI and Crispr Will Be Transformational The genome-editing technology can be supercharged by artificial intelligence—and the results are already being felt.

Merging AI and genome-editing tool Crispr is creating a seismic impact. The future is here, and it's transformative! #BioTechRevolution

www.wired.com/story/combining-ai-and-c...

AI Winners and Losers: Biotech, Batteries, and the Future of Tech

AI Winners and Losers: Biotech, Batteries, and the Future of Tech

https://buff.ly/3YZH5Jf

#BatteryTech #BiotechRevolution #AIInnovation