Minor groove tetrads: a potent and versatile capping interaction for i-motif structures - Biophysical Reviews Minor groove tetrads (MGTs) have emerged as powerful structural elements capable of enhancing the stability and versatility of i-motif DNA structures. These non-canonical tetrads, formed by the minor ...

👏Well done!
Huge kudos to M. Garavís, Bartomeu Mir, I. Serrano, C. Cabrero, C. Ugedo, I. Gómez, N. Escaja & C. González for this outstanding work:

doi.org/10.1007/s125...

#DNAnanotech #iMotif #StructuralBiology #DNAresearch #Biotechnology #NucleicAcids #Biosensing

Exciting application of our programmable #CellCulture matrix #DyNAtrix.

By creating a mechanically reconfigurable microenvironment, we can now invert & guide epithelial cell polarity in real time.

#DNAnanotech

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Electronic Actuation of Surface-Immobilized, pH-Responsive DNA Nanoswitches Dynamic DNA machines exploit the specificity of base pairing and/or sensitivity to the local environment to control the reversible switching of DNA constructs between conformational states. One such e...

🧬New Pre-Print!🧬 PhD candidate Fran D'Rozario explores how pH-sensitive DNA triplexes retain reversible switching in solution, and when densely immobilized on surfaces - a step towards hybrid electronic DNA devices?
👇👇
biorxiv.org/content/10.1...

#DNAnanotech #bioelectronics #smFRET #DNAmachines

DNA Wireframe Revolution: Scaffold-Free Mesh Innovation! DNA wireframe nanostructures breakthrough: BRAIDS creates scaffold-free DNA meshes, innovation molecular engineering without traditional origami methods.

Cubic lattices, complex shapes, better scalability… this could be a game-changer for synthetic biology, nanofabrication, and more. 🧪

Full breakdown + paper link here! 👉 plentyofroom.beehiiv.com/p/dna-wirefr...

#DNAnanotech #biotech #syntheticbiology #nanotech

Now on stage - 2nd Keynote by Yamuna Krishnan 💡🧬
Pioneering DNA nanodevices for real-time imaging and intracellular sensing — decoding the cell from the inside out. Brilliant science! #CSSB25 #DNANanotech #ChemicalBiology

Synthetic CRISPR Networks Driven by Transcription Factors via Structure-Switching DNA Translators CRISPR-Cas systems have advanced many domains in life sciences, enabling diverse applications in gene editing, diagnostics, and biosensing. Here, we introduce a platform that leverages transcription f...

Thrilled to share our latest work published in @jacs.acspublications.org Great group effort resulting in the developement of DNA translators for transcription factor mediated control of CRISPR-Cas activity. #DNAnanotech #SyntheticBio

Hen and egg problem! If you look carefully into biological condensate literature you can find such sharp fronts, which went unnoticed - now we can explain this - and the importance can now be considered in biology.
#softmatter #biomolecularcondensates #DNAnanotech #LLPS #phaseseparation

New preprint on single-molecule mechanostructural fingerprinting! doi.org/10.1101/2025... We use DNA nanoswitch calipers to characterize the geometry and mechanical stability of telomeric DNA G-quadruplexes. #Biophysics #SingleMolecule #Mechanobiology #DNAnanotech

DNA nanotechnology: Scientists are using DNA "stars" to explore "interface flexibility," a crucial factor in building complex structures. This could revolutionize protein design, self-assembly, & nanotherapies. #DNAnanotech #nanoscience #biochemistry

Congratulations to my Masterstudent Kevin for submitting his thesis today @UniHeidelberg! If you want to know more about his work, he will be @nantech2019 or read his paper @AdvSciNews: onlinelibrary.wiley.com/doi/10.1002/adfm.2018086... #DNAnanotech #microfluidics

#DNAnanotech made it on the cover of @NatureNews again! Mona Lisa made from DNA http://www.nature.com/nature/current_issue.html