We had a fantastic conference dinner to close the #CSSB25 at Copenhagen: look at this! 😱 Huge thank you to the organizers Nikos Hatzakis, Morten Meldal, Karen Martinez, Claus Løland & Lucy Holt, as well as the two Deans giving their joint speech here. Had a phenomenal time at the Danish capital. 👌

Now: 🏆 Poster prizes just awarded to the top 4 posters - congratulations to all winners! 🎉 With so much excellent science on display, it was a very tough call for the poster committee. #CSSB25 #PosterPrize #ScienceInAction

..and as a last treat at #CSSB25:
#Nobel laureate #MortenMeldal's lecture about #clicking and its applications.

Fig. caption: he distinguishes: everything ≠ all, since there's a bit of physics... 😉. Plus, a Nobel laureate's advice: get political, you scientists!

And now: Morten Meldal - for me, THE highlight of the conference! 🧪 Host, organizer, and pioneer of click chemistry, he’s now taking the stage for an inspirational talk. A true icon shaping the future of chemical biology! #ClickChemistry @isbuc.bsky.social #CSSB25

Next up: The last flashtalk from Céline Delaitre - presenting her work on fluorescent ligands for angiotensin II AT1 receptors! 🧪 A cutting-edge chemical biology tool to visualize and modulate signaling dynamics. #ChemicalBiology #GPCR #CSSB25

Next up: Jin Zhang - illuminating the biochemical activity architecture of the cell! 🧬 She’s pioneering spatiotemporal biosensors and super-resolution imaging tools to track kinase, phosphatase, GPCR & second messenger activity in living cells. #CellBiology #SuperResolution #CSSB25

Next up: Sonja Schmid @scisonja.bsky.social - presenting the broad-range dynamics of biomolecules uncovered by DyeCycling🌟! She’s using innovative single-molecule fluorescence & nanopore techniques to peer into protein dynamics. Fascinating! #SingleMolecule #ProteinDynamics #CSSB25

@hatzakislab.bsky.social presenting new fast machine-learning based particle tracking tools to extract functional information from diffusion tracks. #deepSPT #CSSB25
www.nature.com/articles/s41...

Last speaker of this session is Nikos Hatzakis @hatzakislab.bsky.social - spotlighting his breakthroughs in 4D single-particle microscopy and machine‑learning analysis to decode enzyme function and cell biology one molecule at a time.🔬🧑‍💻
What a fantastic talk! #SingleMolecule #Biophysics #ML #CSSB25

#BenSchuler with his elegant #IDP #smFRET work next up at #CSSB25 Copenhagen. Reminding everyone about the relevance of intrinsically disordered regions in proteins:

Next up: Ben Schuler - exploring how intrinsically disordered proteins behave in the crowded, dynamic environment of living cells. 🧬 Combining single-molecule spectroscopy with cellular complexity to decode protein folding and function in real time. #ProteinDynamics #SingleMolecule #CSSB25

Looking forward to hearing from #MarkusSauer about his probes and "Molecular resolution fluorescence imaging in cells" at the #CSSB25 Copenhagen.

Up next: Keynote talk by Markus Sauer @sauer-lab.bsky.social - pushing the limits of live-cell imaging! He’s speaking about new strategies to achieve molecular resolution with super-resolution microscopy - in living cells! A breakthrough moment for the field! 🔬🍋 #Microscopy #SuperResolution #CSSB25

Next up: Flashtalk by Mette Malle - unveiling strategies for programmable RNA loading into extracellular vesicles! 🧫 A powerful platform for targeted delivery and functional RNA transport. #RNA #ExtracellularVesicles #SyntheticBiology #CSSB25

Next up: Christian Olsen — presenting on sulfur fluoride exchange (SuFEx) chemistry to target epigenetic regulators! 🔬 A powerful approach to probe and modulate chromatin biology with covalent precision. #ChemicalBiology #Epigenetics #CSSB25

Next up: Thomas Poulsen - diving into precision chemistry from the protein to the proteome! ⚗️ Powerful tools for covalent protein profiling. FANTASTIC work! #ChemBio #Proteomics #CSSB25

Next up: Helma Wennemers - exploring the chemistry of the extracellular matrix! 🧬 Her work on collagen-targeting peptides reveals new ways to image, modulate, and understand ECM biology with precision. #PeptideChemistry #Collagen #ChemicalBiology #CSSB25

Next up: Keynote talk by Ikuhiko Nakase — pioneering strategies for intracellular delivery! 🚀 From cell-penetrating peptides to exosomes and boron-based cancer therapies, his work is transforming how we get molecules where they need to go. Truly exciting! #DrugDelivery #Nanobiotech #CSSB25

After a wonderful poster session, day 1 ends, but day 2 is just about to kick off! 🔬 A lot of structural biology, chemical biology, and super-resolution imaging ahead… here we go! 🚀 #CSSB25 #microscopy #chemistry

So proud of my PhD student @ciarapugh.bsky.social for delivering a brilliant flash talk at the @isbuc.bsky.social #CSSB25 seminar today! She shared our latest work on our native nanodisc-forming copolymer MAASTY and absolutely nailed it.
Heading to #3DEMGRC next week? Don’t miss Ciara’s poster!

Poster session time! 🧫🧠 So many brilliant ideas, creative experiments, and passionate scientists in one room. Come chat, exchange thoughts, and get inspired — this is where the magic happens! #CSSB25 #PosterSession #ScienceInAction

Next flashtalk up: Ciara Pugh 🎤🔬 Excited to hear her latest work developing MAASTY to use at the interface of chemical biology and structural insights. Let’s see what molecular stories unfold! #CSSB25 #ChemicalBiology #StructuralBiology

This was a great talk at #CSSB25 in Copenhagen. Thanks @beliulab.bsky.social 👍

Knud Jensen on stage:
"Selective Chemical Modification of Proteins: His-Tag Acylation" 🧪🔗
Smart strategies to precisely modify proteins using engineered His-tags — elegant and effective! #CSSB25 #ProteinChemistry

Now speaking: Kristian Strømgaard 🧠⚗️ Chemical probes & peptide engineering to dissect membrane proteins and synaptic signaling.
Bridging chemistry and neuroscience with precision tools! #CSSB25 #Neurochemistry #ChemicalBiology

Keynote by Don Hilvert 🧪 Mastering enzyme design and evolution — from mechanistic insights to de novo biocatalysts. A true pioneer in protein engineering! #CSSB25 #EnzymeDesign #ProteinEngineering

Now it’s my turn! Excited to share our latest on GCE & click chemistry for live-cell and super-resolution microscopy 🧬🔬 From precise labeling to functional imaging — come by, join in, and let’s talk science! #CSSB25 #ClickChemistry #Bioimaging

@uniregensburg.bsky.social @uni-wuerzburg.de

Next up: Patricia Bassereau 🧫🧠
Exploring how membrane mechanics and curvature shape cellular trafficking and signaling.
Physics meets biology at the membrane! #CSSB25 #MembraneBiophysics #CellMechanics

Now on stage - 2nd Keynote by Yamuna Krishnan 💡🧬
Pioneering DNA nanodevices for real-time imaging and intracellular sensing — decoding the cell from the inside out. Brilliant science! #CSSB25 #DNANanotech #ChemicalBiology

First Flash Talk at #CSSB25 by Sara Mellemgaard: Microproteins to trigger cancer cell apoptosis 💥🧬
Smart design, functional evolution, therapeutic promise. #Microproteins #Apoptosis