✨Special Topic Dedicated To Prof. Paul Knochel✨

Dirk Trauner @dirktrauner.bsky.social & team use their synthetic azide-based platform to access loline analogues and explore loline as a bidentate ligand for Pd chemistry
#ClickChemistry

#OpenAccess for a limited time 👉 buff.ly/KRqDfG7

We were honored to host 2022 Nobel Laureate Morten P. Meldal at National Taiwan University.

Prof. Meldal shared his vision for a sustainable world, emphasizing that the design logic behind #ClickChemistry isn't just for labs—it's a roadmap for resource efficiency and precision in a changing world.

Accelerating next-generation drug discovery with click-based construction of PROTACs In 2001, chemists K. Barry Sharpless, Hartmuth C. Kolb, and M. G. Finn introduced click chemistry, a concept in which organic molecules can be rapidly and reliably joined to form more complex structures. They recognized that many natural compounds are assembled through efficient carbon–heteroatom (C–X) bond formation, particularly with nitrogen, oxygen, and sulfur, and they sought to replicate this in the laboratory.

✨Chemists unlocked a way to build molecules with incredible speed & precision, mimicking nature's own building blocks! 🧬 #clickchemistry 🤯

Source: phys.org/news/2025-12-generation-...

🚀 Improving the reliability of #ClickChemistry on iron oxide #nanoparticles 
By using better controls, researchers from McGill University @mcgill.ca demonstrated unwanted #CrossReactions, paving the way for safer, truly functional #nanomedicines. 
👉 https://tinyurl.com/mv855keb
#BJNANO 💎🔓

🌱 From the Virtual Collection: #ClickChemistry and #DrugDiscovery
A simple, metal-free, and eco-friendly approach using chitosan·HCl enables rapid hydrazone #synthesis under mild conditions, delivering high yields and promising #antimycobacterial activity.

🔗 Read here: bit.ly/3WZ09Xl
#ChemSky

🧩 From the Virtual Collection: #ClickChemistry and #DrugDiscovery
An efficient click-type formal [2+2] cycloaddition enables the formation of complex #chromophores with remarkable nonlinear optical (NLO) properties.

🔗 Read the full paper: bit.ly/4qpq87O
#ChemSky #OrganicChemistry #OpenAccess

⚗️ From Virtual Collection: #ClickChemistry and #DrugDiscovery

N. Jahan & I. Ansary present a review on the synthesis of bioactive macrocycles using ring-closing metathesis, a powerful strategy enabling access to structures with promising #biological activities.

👉 Read here: bit.ly/4hjC3jv
#ChemSky

@jenabioscience.bsky.social has the most comprehensive catalogue of #nucleotides & #nucleosides for applications in #drugdiscovery #clickchemistry probe labeling ..
Choose your label sugar phosphate label position & more parameters
🔗www.stratech.co.uk/jena_bioscience/nucleoti...

🧩 From the Virtual Collection: #ClickChemistry and #DrugDiscovery
Vinod K. Tiwari & team report a modular and efficient click approach for the synthesis of calix[4]arene-based glycodendrimers bearing lactose (G1) and galactose (G2) units.

👉 Read now: bit.ly/46Vjb5I
#ChemSky

Tertrazines are ideal for pre-targeted imaging, drug delivery, and bioorthogonal chemistry. browse our range of click chemistry reagents and much much more on our site!

#Chemistry #ClickChemistry #Imaging #MolecularBiology #MedChem
fluorochem.co.uk/product-cate...
🧪

🧪 New in #RSCChemicalBiology: Breakthrough in phage display! By combining unnatural amino acids with CuAAC click chemistry, this study expands molecular diversity for next-gen ligand discovery.
doi.org/10.1039/D5CB...
#PhageDisplay #ChemicalBiology #ClickChemistry

And now: Morten Meldal - for me, THE highlight of the conference! 🧪 Host, organizer, and pioneer of click chemistry, he’s now taking the stage for an inspirational talk. A true icon shaping the future of chemical biology! #ClickChemistry @isbuc.bsky.social #CSSB25

Now it’s my turn! Excited to share our latest on GCE & click chemistry for live-cell and super-resolution microscopy 🧬🔬 From precise labeling to functional imaging — come by, join in, and let’s talk science! #CSSB25 #ClickChemistry #Bioimaging

@uniregensburg.bsky.social @uni-wuerzburg.de

inCu-click: DNA-enhanced ligand enables live-cell, intracellular click chemistry reaction with copper catalyst Nature Communications - Tracking biomolecules in living cells requires fast but gentle labeling. Here, authors introduce inCu-click, a DNA-conjugated ligand that localizes copper to enable...

Just published: “inCu-click: DNA-enhanced ligand enables live-cell click chemistry with copper catalyst” in @natcomms.nature.com! 🚀

A DNA-conjugated chelator locks Cu⁺ ions for in situ CuAAC at nanomolar doses—zero toxicity.

Read the full paper here ➡️ rdcu.be/enfHz #clickchemistry

🤠 WANTED: Azide- or Alkyne-Linked Molecules!

😬 Guilty of being incredibly attractive to the Click Chemistry beads available from Bangs Labs!

🏆 Claim your reward today: visit our website at www.bangslabs.com

#clickchemistry #molecules #beads #microspheres #bangslabs

🔬 Discover how #ClickChemistry is revolutionizing #glycoscience!
In this review, Sagar & team explore the synthesis of 1,2,3-triazole-linked glycohybrids with promising bioactivities.
💡 A top 20 most cited article of 2023/2024!

🔗 Read here: www.thieme-connect.com/products/ejo...

A new study from our Team is just published !
Advanced protein engineering + 3 colors single molecule FRET on metabotropic glutamate receptors.
#smFRET #GPCR #fluorescencefriday #clickchemistry

More outstanding work from the @santoshvardhana.bsky.social lab, second preprint dropped this week! Take time to read the bluetorial, including brilliant application of #clickchemistry 👏

Moses elected Fellow of Learned Society of Wales | Cold Spring Harbor Laboratory Cold Spring Harbor Laboratory (CSHL) Professor John Moses has been named a Fellow of the Learned Society of Wales. He is one of 56 leaders and experts elected to this prestigious role from academia, h...

Congratulations to CSHL Prof. John Moses, newly elected Fellow of the Learned Society of Wales (@lswalescddcymru.bsky.social)! A pioneer in click chemistry, Moses is advancing research on cancer, infections, & neurological disease—& honoring his roots.
#ClickChemistry www.cshl.edu/moses-electe...

🚀 Click chemistry meets cancer research!
Triazole-based #cycloadditions provide an efficient pathway to novel #anticancer agents. Check out this must-read, part of SynOpen’s 20 Most-Cited Articles 2023/2024!

🔗 www.thieme-connect.com/products/ejo...

#ClickChemistry #DrugDiscovery #chemotherapy

Novel Click Coupling Chemistry to Explore Glycan Recognition Specific recognition of glycans by proteins is important in many biological processes and immune responses. Here we present a general approach for derivatizing free glycans with a novel linker MTZ (3-...

📢 Our latest work describing a new versatile click chemistry glycan linker which enabled us to create glycan derivatives for use in microarrays, Luminex (bead based arrays) and ELISA assays.

Check it out in @acs.org ACS Central Science doi.org/10.1021/acsc...

#glycotime #clickchemistry #luminex

Thrilled to start my Professorship in `Bioimaging` at @uniregensburg.bsky.social ! Looking forward to exciting science, new ideas, and great collaborations! 🏛️🎓🔬

(Still 1% suspicious it might be an elaborate April Fools’ Joke🤔)
#Bioimaging #ChemicalBiology #ClickChemistry #April1

CFATA UNAM 📑 | #Clickchemistry | #followscience
El artículo de portada del Dr. Gonzalo Ramírez-García y colaboradores: muestra una vista de nubes sobre las montañas de El Puerto de Santa Rosa en Guanajuato (México), que se elevan hasta 2700 m sobre el nivel del mar. 👨‍🔬

🗣️ The #TonyHolýLecture at #IOCBPrague is a tradition honoring excellence in science.

Yesterday, we welcomed Prof. Morten Peter Meldal (Univ. of Copenhagen), #Nobel laureate and #clickchemistry pioneer, who presented his lecture "The #INAIC reaction: An intramolecular click reaction." 1/3

🆕New in #JEV🆕 Small extracellular vesicles engineered using click chemistry to express chimeric antigen receptors show enhanced efficacy in acute liver failure #extracellularvesicles #liverfailure #clickchemistry isevjournals.onlinelibrary.wiley.com/doi/10.1002/...

#ClickChemistry meets living cells: 🔬 Andrea Rentmeister at LMU Munich makes the invisible visible: her research on mRNA therapies & epitranscriptomics combines chemistry & biology - for the medicine of tomorrow. 🔐 #LMUMunich #chemistry #research Find out more: www.lmu.de/en/newsroom/...

What's the future of metal-free #clickchemistry? 🤔 Discover the power of #SuFEx! Explore the latest advancements and learn about the potential of sulfur(VI)-fluoride exchange reactions in our review by Renzo Luisi's group.

#OpenAccess 👉 www.thieme-connect.com/products/ejo...

Delighted to host @howarthsci.bsky.social @phar.cam.ac.uk as our first speaker of 2025 for our #biomedicalscience seminar series

Prof Mark Howarth presented his research on Protein Superglues to control cells and protect from outbreak threats #clickchemistry #celltherapy #vaccines

Frontispiece of Angewandte Chemie Int. Ed. showing a pop-art style drawing of protein structures and a hand symbolizing the protein RNF168.

What a great conclusion to my final days at EPFL: our 🔥article is highlighted on the @angewandtechemie.bsky.social Frontispiece!!

▶️ tinyurl.com/mvtecrsz

@beatfierz.bsky.social #chemicalbiology #clickchemistry #DNArepair #SciArt🐡 🧪

Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment A triple orthogonal linker (T-Linker)-based programmable platform enables integration of therapeutic modules into multimodal targeting chimeras (Multi-TACs) for tumor-targeted co-engagement of differe...

This is a fantastic use of Bioorthogonal chemistry and #clickchemistry to assemble multi-specific engagers to recruit different types of immune cells for #cancerimmunotherapy www.cell.com/cell/fulltex...