Uncoupling tumor immunogenicity from cell death with platinum(IV)-antibody conjugates By uncoupling tumor immunogenicity from cell death, chemically well-defined platinum(IV)–antibody conjugates unlock strong synergy with anti-PD-1 and hig

This is an excellent use of fucosylatransferase by Jie Li at Najing Univ. to construct platinum(IV)-antibody conjugates and induce MHC upregulation #glycotime academic.oup.com/nsr/advance-...

Reciprocal regulation of fibroblast–macrophage equilibrium governs skin integrity - Nature Immunology Turley, Buechler and colleagues show that dermatopontin-expressing fibroblasts provide CSF1 to form a supportive niche for skin-resident macrophages. This interaction is important for skin tissue arch...

#WeekendRead! #EveryCellIsAnImmuneCell! Vollmers Turley &co show @natimmunol.nature.com that lack of CSF1 in skin #fibroblasts decreases macrophage numbers dampening wound repair, and in turn boosts fibroblasts! In human #scleroderma the cellular circuit between fibroblasts & macrophages is altered!

Nice discussions and turnover @pacifichem.bsky.social

Learning a lot about bioorthogonal chemistry and clinical translation, great symposium organized by @pengwu.bsky.social and @siglecdude.bsky.social !

Look forward to seeing everyone in Honolulu

Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy SPPL3 deletion modifies glycosylation on primary T cells, reducing allogeneic immune responses without impairing tumor control by anti-CD19 allogeneic CAR-T cells. SPPL3-null, TCR-sufficient anti-CD19...

This is absolutely the most significant glycobiology paper so far this year. Increasing cell surface N-glycosylation makes viable allo CAR-T cells without deleting the endogenous TCR #glycotime

Octopus 🐙😋

Here is the bottle 😄

I inherited a huge bottle of GDP-fucose from the Paulson lab today, thanks Jim! # glycotime

inCu-click: DNA-enhanced ligand enables live-cell, intracellular click chemistry reaction with copper catalyst Nature Communications - Tracking biomolecules in living cells requires fast but gentle labeling. Here, authors introduce inCu-click, a DNA-conjugated ligand that localizes copper to enable...

In this incredible work, @srouhanifard.bsky.social developed a new catalyst, which makes CuAAC truly biocompatible
rdcu.be/enfHz

Glycosylation-driven programs coordinate immunoregulatory and pro-angiogenic functions of myeloid-derived suppressor cells Blidner et al. identify a glycosylation-dependent, galectin-driven circuit as a common mechanism that simultaneously induces immunosuppressive and pro-angiogenic functions in myeloid-derived suppresso...

The Rabinovichlab discovered that MDSC-specific deletion of ST6Gal1 enhanced GAL1-driven suppressive signals and accelerated tumor growth, effects that can be ameliorated by GAL1-blocking antibodies www.cell.com/immunity/ful...

Such an inspiring talk by Dr. Rabinovich #Glyco27 on the immuno-modulatory functions of galectins #immunotherapy

The 33rd commencement at Scripps starts now

Congratulations to Ellie for successfully defending her Ph.D. Her thesis work provided new insights into the inhibitory interactions between sialoglycans and SIglecs #glycotime We are so proud of you!

Opinion | The White House Tech Bros Owe Their Fortunes to the Research They’re Killing Underlying many investments are breakthroughs in medicine and technology from great universities.

“Given the very real consequences for our competitiveness, our standard of living and, yes, also our bottom lines, we all ought to be making the case for aggressively funding basic science.”

www.nytimes.com/2025/04/28/o...

OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide - Nature Structural & Molecular Biology Here the authors show that the disruption of OGT expression in mouse embryonic stem cells unleashes TET activity, causing genome-wide decreases in DNA methylation and increases in 5-hydroxymethylcytos...

#glycotime "OGT protects the genome against TET-mediated DNA demethylation and loss of heterochromatin integrity, preventing the aberrant increase in transposable element expression noted in cancer, autoimmune-inflammatory diseases, cellular senescence and aging" www.nature.com/articles/s41...

It’s nice meet to meet with @roviralab.bsky.social to discuss our fucosylation enzymes. Thank you for your kind host!

US map via scienceimpacts.org visualization of economic loss due to IDC cuts to 15% as part of Feb 7, 2025 executive order, with shading denoting intensity of cuts.

Working with an interdisciplinary team, we have developed a website to communicate how the White House's proposed cuts to health research would cause losses of $16B and 68,500 jobs.

Find out how your community may be impacted.

Explore more at SCIMaP: scienceimpacts.org

a 🧵

Probing altered receptor specificities of antigenically drifting human H3N2 viruses by chemoenzymatic synthesis, NMR, and modeling Nature Communications - Binding modes of antigenically drifted hemagglutinins of human influenza A viruses have been determined by NMR using synthetic N-glycans having 13C-labeled monosaccharides...

@rpdevrieslab.bsky.social fantastic work on the involvement of the LacNAc chains in human influenza A virus hemaglutinin receptor interactions #glycotime rdcu.be/dD4Q0

Excellent news!

Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis The immunosuppressive tumour microenvironment (TME) reduces immune response effectiveness in stromal-rich tumours, including CMS4 colorectal cancer (CRC). Mesenchymal stromal cells (MSCs), precursors ...

Stromal cell sialylation suppresses NK cell function through Siglec-10 engagement #glycotime www.biorxiv.org/content/10.1...

Musk is not here, please post on X 🤗

Bad news — the effective freeze at the NIH’s Center for Scientific Review hits a major chemical biology study section. Not good. @jeremymberg.bsky.social

The NIH Memo That Undercut Universities Came Directly From Trump Officials NIH officials said they were given no advance warning and less than an hour to post the memo publicly.

www.theatlantic.com/health/archi...

Opinion | American Science is Under Attack (Gift Article) The Trump administration hobbles research and endangers the public health.

If our "academic leaders" are wondering what a real leader looks like, look no further. Who will follow Dr. Varmus?
www.nytimes.com/2025/02/14/o...

Look forward to speak at the 2025 Carbohydrate GRC #glycotime

NIH cuts billions of dollars in biomedical funding, effective immediately The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.

Another assault on US competitiveness at a time when biomedicine is roaring with innovation, an own-goal in a high-stakes international tournament. Of course the real losers are American people needing medicines and cures.

www.washingtonpost.com/health/2025/...

Many people do not even disclose construct seq for antibodies and CARs.

Changes in Glycosylation on the Cell Surface Result in Highly Potent and Long-Lasting Allogeneic CAR-T Therapy in Patients Disclosures. No relevant conflicts of interest to declare.

Enhancing glycosylation levels is good for CAR-T, maintaining their anti-tumor efficacy without causing GvHD #glycotime