AI-designed enzymes are here! A trio of diffusion models—RFdiffusion2, RFdiffusion3 & Riff-Diff—are solving long-standing challenges in enzyme design, enabling new reactions never seen in nature. The age of programmable chemistry begins. 🔍⚗️🧬
#AIforScience #EnzymeDesign
cen.acs.org/physical-che...

🚀 Big news from #Hephaistos ⚙️ The #ETH startup
is launching its first industrial pilot with #SpiroChem, bringing de novo designed enzymes from the lab into real-world chemical synthesis > tinyurl.com/ynyja5nk
@ethz.ch #ETHstartup #Biotech #Biocatalysis #EnzymeDesign

Done for today
#teaching #biomoleculardesign #enzymedesign #pymol

Who can guess the enzyme?

Customizing the Structure of a Minimal TIM Barrel to Craft a De Novo Enzyme The TIM barrel is the most prevalent fold in natural enzymes, supporting efficient catalysis of diverse chemical reactions. While de novo TIM barrels have been successfully designed, their minimalisti...

In collaboration with @birtehoecker.bsky.social, we’ve unlocked enzymatic activity in a minimal de novo TIM barrel by designing a custom lid for catalysis! 🧵👇
#ProteinDesign #EnzymeDesign

Customizing the Structure of a Minimal TIM Barrel to Create a De Novo Enzyme
www.biorxiv.org/content/10.1...

Keynote by Don Hilvert 🧪 Mastering enzyme design and evolution — from mechanistic insights to de novo biocatalysts. A true pioneer in protein engineering! #CSSB25 #EnzymeDesign #ProteinEngineering

Assembly instructions for enzymes: Universal rules can help to design an optimal enzyme from scratch In biology, enzymes have evolved over millions of years to drive chemical reactions. Scientists from the Max Planck Institute for Dynamics and Self-Organization (MPI-DS) have now derived universal rules to enable the de novo design of optimal enzymes.

✨Millions of years of evolution unlocked! Scientists are now *designing* optimal enzymes from scratch!🤯 A new era for biology & chemistry!🔬 #EnzymeDesign

Source: phys.org/news/2025-05-enzymes-uni...

📣We offer a #PhDposition in #MachineLearning for #EnzymeDesign in Mehdi Davari's group. Funded within the Priority Programme SPP2363 “Molecular Machine Learning” by @dfg.de.

🔗All information: www.ipb-halle.de/en/career/jo...

📅Apply now!

#Bioinformatics
#Chemoinformatics
#Joboffer
#Scijobs

Designing Life’s Catalysts: Scientists Build Enzymes from Scratch Researchers have developed a workflow to design enzymes from scratch — enabling greener chemistry, novel reactions, and tailor-made catalysts that rival nature’s best.

Why borrow from nature when you can build better? Scientists just created enzymes from scratch — unlocking cleaner, smarter chemistry. #EnzymeDesign #GreenChemistry #SyntheticBiology

🚨Out now in Angewandte Chemie:

AI.zymes - A modular platform for evolutionary enzyme design.

AI.zymes integrates established and emerging bioengineering tools into a coherent pipeline for #enzymedesign.

📄Paper: doi.org/10.1002/anie...
💻GitHub: github.com/bunzela/AIzy...

Ammonia is key to fertilizers and essential to feed the world.🌍Its industrial production consumes ~2% of the global energy.
In this fully funded PhD project, you'll combine #enzymedesign and #directedevolution to turn nitrogen into ammonia.💡🌱

Distal mutations in a designed retro-aldolase alter loop dynamics to shift and accelerate the rate-limiting step Amino-acid residues distant from an enzyme’s active site are known to influence catalysis, but their mechanistic contributions to the catalytic cycle remain poorly understood. Here, we investigate the...

Together, our findings reveal how distal mutations sculpt enzyme function by reshaping the catalytic cycle for more efficient catalysis.

What does this mean for enzyme design? Find out in our preprint: www.biorxiv.org/content/10.1...
#Enzymology #Biophysics #Catalysis #EnzymeDesign

AI.zymes was developed primarily by Master students at
ETH Zurich and U Bristol!

Thanks to Lucas, Jannik, Abbie, Vivienne, Moor, Tudor, and Adrian for advancing #enzymedesign and bringing AI.zymes to life!🎉

Biomatter Raises €6.5M to Revolutionize Enzyme Design with Generative AI

Biomatter Raises €6.5M to Revolutionize #EnzymeDesign with #GenerativeAI: With fresh funding, Biomatter aims to revolutionize enzyme creation using its Intelligent Architecture™ platform, enabling rapid innovation across multiple industries. #synbio

Happy to announce our latest article on #enzymedesign, in collaboration with Mike Thompson's group! Check it out in JACS:

Design of Efficient Artificial Enzymes Using Crystallographically Enhanced Conformational Sampling

pubs.acs.org/doi/full/10....