Could protein folding vibrations act as cellular thermometers, sensing metabolic heat? What implications does this have for disease mechanisms? #ProteinDynamics #Biophysics #academicsky #ProteinDynamics #Biophysics #academicsky
[DISCUSSION] Could protein vibrations encode cellular information like molecular Morse code? What implications does this have for drug design? #ProteinDynamics #MolecularSimulations #Biophysics #ProteinDynamics #MolecularSimulations #Biophysics
#MolecularDynamics analyses of CLDN15 pore size and charge selectivity. New study from Sarah McGuinness, Le Shen, Fatemeh Khalili-Araghi, Christopher R. Weber and colleagues (University of Chicago): rupress.org/jgp/article/...
#MembraneTransport #Biophysics #ProteinStructure #ProteinDynamics
Currently wrapping up a project that I inhereted from someone I never met when I started at my current employer. It was in fact a large project with lots of good work and commitment from colleagues. The part that I worked on: #proteindynamics 🧬
Initally I thought, well ...
🇺🇸 Heading to #Novalix? Learn how confocal fluorescence spectroscopy accelerates induced-proximity drug screening. Meet our US team, Audrey & Jake, to discuss #biophysicalscreening, #molecularglues and #PROTACs, #single-molecule #proteindynamics, and more. Look out for their booth and poster!
📢 Structural biochemists: do you have beautiful, atomic-resolution static structures, but feel like a piece of the puzzle is missing? Add single-molecule dynamics with smFRET to reveal hidden conformational changes 👉 excitinginstruments.com/resource-lib...
#structuralbiology #proteindynamics
Correlating Protein Dynamics and Catalytic Activity of a Model Hydrogenase Using Paramagnetic and Biological Nuclear Magnetic Resonance Spectroscopy.
Buchko, Garry W et al.
Paper
Details
#ProteinDynamics #NMR #Hydrogenase
A critical residue mediates proper assembly and gating of GIRK2 channels. New study from Ha Nguyen, Paul A. Slesinger and colleagues @sinaibrain.bsky.social: rupress.org/jgp/article/...
#Biochemistry #MolecularPharmacology #ProteinStructure #ProteinDynamics #Biophysics #IonChannels
On the mechanism of K⁺ transport through the inter-subunit tunnel of KdpFABC. New study from Hridya Valia Madapally, Himanshu Khandelia @khandeliagroup.bsky.social and colleagues @sdu.dk: rupress.org/jgp/article/...
#MembraneTransport #ProteinStructure #ProteinDynamics #Biophysics
Novel binding mode for negative allosteric #NMDA receptor modulators, from James Lotti, Rasmus Clausen @ucph.bsky.social, Kasper Hansen and colleagues @umontana.bsky.social: rupress.org/jgp/article/...
#MolecularPharmacology #ProteinStructure #ProteinDynamics #Biophysics
📝 Online now - the Feature Review "Protein codes and mobility together shape cellular function and disease" from Henry Kilgore, Shannon Moreno, and Richard Young.
#BiomolecularCondensates #Proteolethargy #MacromolecularCrowding #ProteinDynamics
Read it here 👉 authors.elsevier.com/a/1mB6J3S6Gf...
Two hours to go! Join @shenk0128.bsky.social and @timcraggs.bsky.social as they dive into Rag GTPase regulation, #proteindynamics, and cutting-edge #singlemolecule science. Can’t make it live? Register to get the recording - us06web.zoom.us/meeting/regi...
#biophysics #lifescience #biophysics
Nucleotide asymmetry and flexible linker dynamics modulate drug efflux cycle of P-glycoprotein, A computational study. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.064
🔗 Nucleotide asymmetry and flexible linker dynamics modulate drug efflux cycle of P-glycoprotein, A computational study. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...
📚 CSBJ: www.csbj.org
#DrugResistance #StructuralBiology #ProteinDynamics #Biophysics #Pgp #ABCB1
Integrating AlphaFold pLDDT Scores into CABS-flex for enhanced protein flexibility simulations. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.11.047
🔗 Integrating AlphaFold pLDDT Scores into CABS-flex for enhanced protein flexibility simulations. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...
📚 CSBJ: www.csbj.org
#Biophysics #ProteinDynamics #AlphaFold #CABSflex #StructuralBiology #MolecularModeling
Proteins aren’t static snapshots—they’re dynamic ensembles driving function ⚡ Let’s think beyond single structures and embrace motion to truly understand biology. What do you think? 🔬 #proteindynamics #molecularmotion
idees.moleculair.es/proteins-in-...
Passionate about enzyme structure, function, and dynamics, and applying that knowledge to drug discovery? 💊🧬🧫🧪 We’re recruiting a Postdoc!
Come join us! Apply: wzhulab.com/contact
#PostdocJobs #Biochemistry #Enzymology #Metalloenzymes #ProteinDynamics
Dynamic energy conversion in protein catalysis: From brownian motion to enzymatic function. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.07.050
🔗 Dynamic energy conversion in protein catalysis: From brownian motion to enzymatic function. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...
📚 CSBJ: www.csbj.org
#ProteinDynamics #EnzymaticCatalysis #Biophysics #StructuralBiology #EnzymeEngineering #Biochemistry
NALCN/Cch1 channelosome subunits originated in early eukaryotes. New study from Adriano Senatore @utoronto.ca and colleagues: rupress.org/jgp/article/...
#Lipids #membranes #MolecularPhysiology #ProteinStructure #ProteinDynamics #CellBiology #Evolution #IonChannels
Single-molecule measurements in solution expose heterogeneity, rare events, and real-time dynamics without immobilisation, yielding precise kinetic and mechanistic insights. Learn more: excitinginstruments.com?utm_source=b... #proteindynamics #DNAproteininteractions #structuralbiology #biophysics
Ring flips or tyrosine or phenylalanine require some collective motion to occur. Sometimes called "breathing motion". By comparing ring-flip dynamics in solution, crystals and in an antibody-complex using #NMR, we, thus, get insights into collective motions. #Biophysics #ProteinDynamics
Excited that we are only two weeks away for our Next Generation Biophysics Symposium 2025. We have a fantastic line-up of speakers. Registration is closing soon. Come in person or view on-line
#Biophysics #SingleMolecule #CryoEM #nmr #proteindynamics
New preprint with Benjamin Lang, Richard Kriwacki, John Christodoulou, and M. Madan Babu!
www.biorxiv.org/content/10.1...
Protein Dynamics at Different Timescales Unlock Access to Hidden Post-Translational Modification Sites
#bioinformatics #compchem #folding #proteindynamics
Next up: Sonja Schmid @scisonja.bsky.social - presenting the broad-range dynamics of biomolecules uncovered by DyeCycling🌟! She’s using innovative single-molecule fluorescence & nanopore techniques to peer into protein dynamics. Fascinating! #SingleMolecule #ProteinDynamics #CSSB25
Next up: Ben Schuler - exploring how intrinsically disordered proteins behave in the crowded, dynamic environment of living cells. 🧬 Combining single-molecule spectroscopy with cellular complexity to decode protein folding and function in real time. #ProteinDynamics #SingleMolecule #CSSB25
Disruption of a side portal pathway permits closed-state inactivation by BK β subunit N-termini, say Yu Zhou, Xiao-Ming Xia, and Christopher Lingle @washumedicine.bsky.social: rupress.org/jgp/article/...
#Biophysics #ProteinStructure #ProteinDynamics #MolecularPhysiology #IonChannels #BKChannels
Dynamic lid domain of Chloroflexus aurantiacus Malonyl-CoA reductase controls the reaction #carbonfixation #proteindynamics #proteincrystallography www.sciencedirect.com/science/arti...
We are pleased to welcome Dr. Lipi Thukral (CSIR-IGIB) to the JBSD Editorial Board. Her work in computational protein and lipid dynamics will enrich our journal's scope. #JBSD #ProteinDynamics @lipithukral.bsky.social www.igib.res.in?q=LipiThukral
We are pleased to welcome Professor T. Michael Sabo (University of Louisville) to the JBSD Editorial Board. His expertise in protein dynamics and NMR spectroscopy will enhance our journal’s focus on biomolecular structure and function. #JBSD #ProteinDynamics #NMR
#research #proteindynamics #biophysics
Unraveling the Tether: Exploring Representative Protein Linkers and Their Structural and Thermodynamical Properties (Šulc, Vondrášek) – JPhysChem B: doi.org/10.1021/acs....
@iocbprague.bsky.social @czechacademy.bsky.social @sciencecharles.bsky.social
I had the pleasure of presenting my project at VAAM 2025 in Bochum, Germany.
It was an honor to share my research in such a stimulating and engaging scientific setting.
#VAAM2025 #Microbiology #ProteinDynamics #StructuralBiology #EscherichiaColi #ScienceCommunication #LMU #AdiY
