Clinical Value of ABCB1 and PAI-1 Gene Polymorphisms in Predicting Glucocorticoid-induced Adverse Reactions in Nephrotic Syndrome Patients

This study shows that #ABCB1 #C3435T & PAI 1 4G/5G polymorphisms are linked to #Glucocorticoid-induced adverse reactions in #NephroticSyndrome, & screening before #SteroidTherapy helps identify high-risk patients & guide personalized therapy. #medsky

Read: doi.org/10.1007/s115...

Nucleotide asymmetry and flexible linker dynamics modulate drug efflux cycle of P-glycoprotein, A computational study. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.064

🔗 Nucleotide asymmetry and flexible linker dynamics modulate drug efflux cycle of P-glycoprotein, A computational study. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#DrugResistance #StructuralBiology #ProteinDynamics #Biophysics #Pgp #ABCB1

Clinical Value of ABCB1 and PAI-1 Gene Polymorphisms in Predicting Glucocorticoid-induced Adverse Reactions in Nephrotic Syndrome Patients

This study investigates the role of #ABCB1 C3435T and PAI-1 4G/5G polymorphisms in #NephroticSyndrome, aiming to identify patients at high risk of developing #steroid-induced adverse reactions such as SANFH and S-DM. #medsky

Read more: link.springer.com/article/10.1...

🧬 #ABCB1 encodes P-glycoprotein, a “drug pump” moving chemo drugs out of cells. Variants can alter response - sometimes the difference between a drug that works and one that fails #GeneFact #Genomics #CancerResearch #CKB

Can targeting #SUMOylation open new doors in #OvarianCancer treatment? 🔍🧬

New #iScience study screened 30 patient-derived models — finding #MYC sensitivity & #ABCB1 resistance. A step toward #PersonalisedMedicine 💡

🧾 www.sciencedirect.com/science/arti...

#CancerResearch #TargetedTherapy #Drug

Now online - the Review "Plant steroids on the move: mechanisms of #brassinosteroid export" from @jennyrussinova.bsky.social and co.

#PlantHormones #ABCTransporter #ABCB19 #ABCB1

Read it here: authors.elsevier.com/a/1kx%7Ex3S6...

New Study! Published in The EMBO Journal, this research reveals how Salipro®-embedded #ABCB1 recognizes and transports various substrates, crucial for tackling drug resistance in cancer and other diseases. Congrats to Amer and the team! embopress.org/doi/full/10.... #CryoEM

Structural insights into binding-site access and ligand recognition by human ABCB1 | The EMBO Journal imageimageABCB1-dependent multidrug resistance is a major cause of reduced efficacy of drug-based therapy. The cryo-EM-derived structures of ABCB1 presented here reveal a previously uncharacterized au...

www.embopress.org/doi/full/10....

Our latest manuscript on human #ABCB1 / #MDR1 / #p-glycoprotein / #pgp / #p-gp structures, No stabilizing antibodies or mutations. 4 conformations including a novel apo state in saposin lipid nanoparticles out in The EMBO Journal @embojournal.bsky.social