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Structural insights into binding-site access and ligand recognition by human ABCB1 | The EMBO Journal imageimageABCB1-dependent multidrug resistance is a major cause of reduced efficacy of drug-based therapy. The cryo-EM-derived structures of ABCB1 presented here reveal a previously uncharacterized au...

www.embopress.org/doi/full/10....

Our latest manuscript on human #ABCB1 / #MDR1 / #p-glycoprotein / #pgp / #p-gp structures, No stabilizing antibodies or mutations. 4 conformations including a novel apo state in saposin lipid nanoparticles out in The EMBO Journal @embojournal.bsky.social