Can the functions of #metalloenzymes be further improved using non-canonical amino acids?

In her talk at #Biochemistry2026, Alexandra Deliz Liang talked about the usage of genetic code expansion in order to improve the activity of metalloenzymes.

www.biorxiv.org/content/10.1...
#ChemSky #ChemBio

A kinetically impaired Gln143Asn MnSOD variant is used to trap and explore additional hydrogen peroxide-binding sites beyond the second-shell solvent gate #ManganeseSuperoxideDismutases #PeroxideBinding #Metalloenzymes doi.org/10.1107/S205...

1️⃣ 𝗠𝗜𝗕𝗧𝗣-𝗕𝗕𝗦𝗥𝗖 - 𝟮𝟳𝘁𝗵 𝗡𝗼𝘃𝗲𝗺𝗯𝗲𝗿 𝟮𝟬𝟮𝟱 𝗱𝗲𝗮𝗱𝗹𝗶𝗻𝗲:
warwick.ac.uk/fac/cross_fa...

2️⃣ 𝗖𝗘𝗡𝗧𝗔-𝗡𝗘𝗥𝗖 - 𝟳𝘁𝗵 𝗝𝗮𝗻𝘂𝗮𝗿𝘆 𝟮𝟬𝟮𝟲 𝗱𝗲𝗮𝗱𝗹𝗶𝗻𝗲:
centa.ac.uk/studentship/...

Any questions or more information? Please email me, happy to help!

#metalloenzymes #biohybridcatalysts #sustainablechemistry #greenchemistry

Are you excited about #metalloenzymes and #biohybridcatalysts? Are you interested in investigating new approaches for #sustainable and #greenchemistry?

If so, I have 𝘁𝘄𝗼 𝗣𝗵𝗱 𝗽𝗼𝘀𝗶𝘁𝗶𝗼𝗻𝘀 to join my group in 📅 Sept 2026 under the schemes.

👇+Info👇

Contact — Wen Zhu Laboratory Use this space to add a brief description of your project.

Passionate about enzyme structure, function, and dynamics, and applying that knowledge to drug discovery? 💊🧬🧫🧪 We’re recruiting a Postdoc!
Come join us! Apply: wzhulab.com/contact
#PostdocJobs #Biochemistry #Enzymology #Metalloenzymes #ProteinDynamics

Advancing Metalloenzyme Therapeutics: Insights from Blacksmith Medicines at 21st International Conference Blacksmith Medicines showcased their pioneering work on metalloenzyme therapeutics at the International Conference on Biological Inorganic Chemistry, highlighting their drug development strategies.

Advancing Metalloenzyme Therapeutics: Insights from Blacksmith Medicines at 21st International Conference #USA #Long_Beach #Blacksmith_Medicines #LpxC #metalloenzymes

Me and my poster at SCS2025! What a great conference it was :-)

If you're interested in enzymatic hydrogen evolution, let me know and let's talk!

#SCS2025 #chemistry #poster #science #catalysis #metalloenzymes #hydrogen