Biophysical and biological properties of splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages Abstract. Antisense oligonucleotides hold great promise in the treatment of disease, but their efficacy is limited by modest bioavailability and toxicity.

Glad to share our new paper online! Splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages academic.oup.com/nar/article/...
#RNAtherapeutics #Oligonucleotides #SpliceSwitching #Phosphorothioate #NucleicAcids