Synthetic aptamer mechanoreceptors enable cell-specific force sensing and temporal control via DNA circuits - Nature Communications Engineering synthetic mechanosensing systems with both cell-specificity and programmability remains challenging, especially for classical mechanoreceptors. Here, the authors develop an all-DNA mechano...

Excited to share “Synthetic Aptamer Mechanoreceptors Enable Cell-Specific Force Sensing and Temporal Control via DNA Circuits.” in NatComm. This is our most significant excursion into mechanobiology #mechanobiology #DNAnanoscience #aptamers www.nature.com/articles/s41...

🧬 We show this first with switchable DNA logic:
AND ↔ OR gates realized using the same DNA network — logic reassigned purely by reconfiguring microfluidic flow paths. #DNAnanoscience

ATP‐Powered Signaling Between Artificial and Living Cells We introduce an ATP-powered artificial cell platform capable of selectively and transiently releasing DNA signals to facilitate communication between artificial and living cells. By engineering these...

Congratulations to Soumya and Charu for making the first ATP-fueled homeostatic cytokine delivery system for communication between artificial and living cells. Now in Angewandte Chemie @angewandtechemie.bsky.social #syntheticcell #noneqsys #DNAnanoscience
onlinelibrary.wiley.com/doi/10.1002/...

What a surprise, we always think that chol-ssDNA stays on the outside of the membrane, but here we learn that this is not correct! Generic across many lipid compositions, for different DNAs. Everything flips! A defect-mediated process. #syncell #DNAnanoscience #RNA A great information highway!