Divalent siRNA for prion disease Prion protein (PrP) lowering is effective in animal models of prion disease and is being tested clinically in prion disease patients, but there remains a need for more potent PrP-lowering drug candidates....

🧬 Learn more about divalent #siRNAs for prion disease from the Khvorova, Vallabh, & Minikel labs: buff.ly/pdhVPk8
siRNA from bench to clinic: buff.ly/f3i8poM
#RNA #RNATherapeutics @umasschan.bsky.social

Divalent siRNA for prion disease Prion protein (PrP) lowering is effective in animal models of prion disease and is being tested clinically in prion disease patients, but there remains a need for more potent PrP-lowering drug candidates....

🧬 Learn more about divalent #siRNAs for prion disease from the Khvorova, Vallabh, & Minikel labs: buff.ly/pdhVPk8
siRNA from bench to clinic: buff.ly/f3i8poM
#RNA #RNATherapeutics @umasschan.bsky.social

Long-distance transport of siRNAs with functional roles in pollen development - Nature Plants This study shows that many small RNAs in Capsella rubella pollen originate from maternal tissues. These mobile small RNAs support proper pollen development, revealing that non-cell-autonomous small RN...

New paper in @natplants.nature.com finds that #siRNAs can act as long-distance communication signals from maternal to male tissue in #Capsella with functional role in #pollen development.

Read here: nature.com/articles/s41477-026-02219-6

@claudiakohler11.bsky.social @jiali024.bsky.social

This review discusses small nucleic acid therapeutics, highlighting advances in chemical modifications and delivery platforms, profiles approved drugs like #AntisenseOligonucleotides, #aptamers, and #siRNAs, and addresses clinical challenges.

#STTT: doi.org/10.1038/s413...

📚MedChemExpress Digest | #JAKSTAT in #AutoimmuneTreatment
🔹JAK #inhibitors: Tofacitinib, Baricitinib, Ruxolitinib; Upadacitinib 🔹Cytokine #antibodies: daclizumab, anti-IL-5, tocilizumab, siltuximab 🔹Emerging modalities: #Peptide , #oligos , #siRNAs
🔗https://ow.ly/b8Gx50Xmfqy