Upcoming Webinar: Exploring How Genome Organization Shapes Biological Function Free registration: www.jax.org/genometechdev26 Join us for an exciting webinar bringing together leading researchers who are uncovering new layers of genome regulation and nuclear organization. Featured Speakers & Talks: Martha Bulyk – Revealing additional layers of cis‑regulatory codes governing transcription factor interactions Wenyi Feng – Linking cytoplasmic single‑stranded DNA detection to Fragile X Syndrome pathology Mitchell Guttman – RNA promotes the formation of spatial compartments throughout the nucleus This webinar will explore how regulatory DNA, RNA, and nuclear architecture intersect to shape biological function and disease mechanisms.

Final session of the Genome Technology Development Webinar Series APRIL 7 @ 1PM ET
register: www.jax.org/genometechdev26
This webinar will explore how regulatory DNA, RNA, and nuclear architecture intersect to shape biological function and disease mechanisms. 🧪💻🧬👩‍🔬

Supported by NHGRI and @jax.org

2026 Genome Technologies Development Series - The Jackson Laboratory

There's still time to register for today's webinar at 2PM EDT.
👉www.jax.org/genometechdev26👈
Charting Cellular Futures: Lineage Recording and Regulatory Network Insights. 🧪💻🧬
Speakers:
@jshendure.bsky.social and @jbuenrostro.bsky.social

Mark Adams honored as 2025 AAAS Fellow for his contributions to genomics At The Jackson Laboratory, Adams’ leadership in genomics builds on a career of pioneering work in DNA sequencing and genome mapping that has helped lay the foundation for modern precision medicine

Huge congratulations to Mark Adams, professor and interim scientific director at The Jackson Laboratory for Genomic Medicine, who has been elected a 2025 Fellow of @aaas.org — one of the most distinguished lifetime honors for scientists. 🎉 🧪

Flexomics: Advancing Single-Cell Biology with Integrated Imaging and Sequencing YouTube video by GenomeTDCC

Wonder how to directly connect live-cell behavior with the molecular states driving it?
Magali Soumillon, Co-Founder & CEO of Flexomics, introduces a single-cell platform that merges live-cell imaging with sequencing from the same cells.
🧪💻🧬👩‍🔬
youtu.be/RH8WBbZMXIQ

Congratulations Xin Jin!
🧪👩‍🔬🧬💻

The Genome Technology Development Webinar Series.
👉 www.jax.org/GenomeTechDev26 👈
Three webinars featuring leading scientists discussing current capabilities, ongoing challenges, and future opportunities in genome technology innovation. Roundtable discussion following the presentations 🧪🧬💻👩‍🔬 #edusky

The TDCC in conjunction with NHGRI and The Jackson Laboratory invite you to the free Genome Technologies Development Webinar Series. Registration: www.jax.org/GenomeTechDev26 Rapid advances in genomic analysis have increased the efficiency, accuracy, and depth of biological discovery, and these improvements are driven by innovative approaches in spatial profiling, single-cell genomics, functional genomics, and genome organization. This series brings together experts whose research continues to expand the frontiers of genome technology. The sessions are designed for postsecondary students, postdoctoral fellows, and biomedical researchers who are seeking a deeper understanding of how emerging tools are developed, applied, and refined. Each event includes scientific presentations and a roundtable discussion that examines current capabilities, ongoing challenges, and future opportunities in genome technology innovation. Revealing Biological Complexity Through Spatial Profiling 26, MARCH 3:00 – 4:00 PM ET Speakers: Fei Chen, Ph.D. Roy Wollman, Ph.D. Moderator: Ramalakshmi Ramasamy, Ph.D. Charting Cellular Futures: Lineage Recording and Regulatory Network Insights 31, MARCH 2:00 – 3:00 PM ET Speakers: Jay Shendure MD, Ph.D. Jason Buenrostro, Ph.D. Moderator: Yashwanth Ashok, Ph.D. Exploring How Genome Organization Shapes Biological Function 7, APRIL 1:00 – 2:00 PM ET Speakers: Martha Bulyk, Ph.D. Wenyi Feng, Ph.D. Mitch Guttman, Ph.D. Moderator: Inés Patop, Ph.D.

Have you registered for the Genome Technologies Development Webinar Series?? 🧪🧬💻👩‍🔬
www.jax.org/GenomeTechDev26

Each session includes scientific presentations and a roundtable discussion examining current capabilities, ongoing challenges, and future opportunities in genome technology innovation.

Exploring How Genome Organization Shapes Biological Function A webinar featuring Martha Bulyk, Wenyi Feng, and Mitchell Guttman. Registration: www.jax.org/genometechdev26 April 7, 1:00 PM - 2:00 PM ET

You're invited to the webinar session:
Exploring How Genome Organization Shapes Biological Function
Featuring Martha Bulyk, Wenyi Feng, and Mitchell Guttman.
🧪🧬💻👩‍🔬
Free Registration: www.jax.org/genometechdev26
📅 April 7, 1:00 PM - 2:00 PM ET

🧪🧬💻👩‍🔬

Free webinar featuring Jay Shendure and Jason Buenrostro. Charting Cellular Futures: Lineage Recording & Regulatory Network Insights. March 31 2pm ET. Register www.jax.org/GenomeTechDev26/

Coming Soon: March 31 @2pm ET. 📅
Charting Cellular Futures: Lineage Recording & Regulatory Network Insights.
Free webinar featuring @jshendure.bsky.social and @jbuenrostro.bsky.social.

Register www.jax.org/GenomeTechDev26/
🧪🧪💻

TDCC is hosting a webinar series featuring leading innovators. Free registration at www.jax.org/GenomeTechDev26

Genomic technologies are quickly advancing! Check out our webinar series featuring leading innovators. 🧪🧬💻
Register once for 3 Webinars:
www.jax.org/genometechde...
Speakers:
Fei Chen
Roy Wollman
Martha Bulyk
@mitchguttman.bsky.social
Wenyi Feng
@jshendure.bsky.social
@jbuenrostro.bsky.social

Revealing Biological Complexity Through Spatial Profiling webinar. Featuring Roy Wollman and Fei Chen. March 26 at 3 PM ET.

You're invited to the webinar "Revealing Biological Complexity Through Spatial Profiling", featuring Roy Wollman and Fei Chen. Session moderator: Ramalakshmi Ramasamy

March 26, 3 - 4 PM ET
Free Registeration: www.jax.org/genometechde...

Presented with support by @jaxeducation.bsky.social
🧪🧬💻

Genomics & single-cell researchers—expand your toolkit. 👨‍🔬Learn how Paired-Damage-seq links DNA damage with transcriptomics in our webinar with Epigenome Technologies.

Register Here: 👉 app.livestorm.co/epicypher/single-cell-dn...

Nucleosome context regulates chromatin reader preference Abstract. Chromatin is more than a simple genome packaging system but rather locally distinguished by histone post-translational modifications (PTMs) that

Captify: A new platform to study chromatin readers in the nucleosome context 🧪💻🧬
Recently published in Nucleic Acids Research @narjournal.bsky.social, the folks at @epicypher.bsky.social discuss development & integration of these easily adoptable biochemical and genomic tools
doi.org/10.1093/nar/...

🧪🧬💻
Congratulations on the recent publication from @jshendure.bsky.social, @troymcdiarmid.bsky.social, @uwgenome.bsky.social and colleagues!
👇
www.nature.com/articles/s41...

Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here:
www.biorxiv.org/content/10.1...

Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution RAEFISH delivers whole-transcriptome (>20,000 genes) imaging at single-molecule resolution in cells and tissues and enables direct gRNA detection for high-content, image-based CRISPR screens.

👀 Read all the details - recently published in @cellpress.bsky.social
www.cell.com/cell/fulltex...

Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution YouTube video by GenomeTDCC

New highlight video! 🧪🧬💻
RAEFISH from Steven Wang at Yale unlocks whole-transcriptome imaging at single-molecule resolution. See 20,000+ RNAs light up in cells and tissues. Plus get direct gRNA detection in high-content CRISPR screens. Spatial biology just leveled up

www.youtube.com/watch?v=P2j6...

DNA Bendability Regulates Transcription Factor Binding to Nucleosomes (PIONEAR-seq) YouTube video by GenomeTDCC

New video! Discover how transcription factors find their way through tightly packed DNA. 🧪🧬💻👩‍🔬

www.youtube.com/watch?v=gOta...

Luca Mariani & Martha Bulyk introduce PIONEAR-seq, revealing how DNA flexibility shapes gene regulation.

Recently published in @natsmb.nature.com

SO many great talks from leading scientists who develop and use various genomic technologies. 🧪🧬💻👩‍🔬

Genome architecture, RNA regulation + modification identification, nanopores, DNA writing, statistics, sequencing!

It's all there on the GenomeTDCC YouTube channel!
www.youtube.com/playlist?lis...

Non-profits wade in where for-profit life science investment fears to tread - Nature Biotechnology For decades, and in the exceptional instance of the Institut Pasteur for over a century, non-profit organizations have augmented R&D to advance scientific understanding and develop affordable and ...

Non-profits wade in where for-profit life science investment fears to tread nature.com/articles/s41...
rdcu.be/eyzXy

PADIT-seq: Protein affinity to DNA by in vitro transcription and RNA sequencing YouTube video by GenomeTDCC

Don't miss hearing from Shubham Khetan and Martha Bulyk in this publication highlight video where they discuss their work developing PADIT-seq. 🧪
youtu.be/45hdZ6R9fX4

PADIT-seq: Protein affinity to DNA by in vitro transcription and RNA sequencing YouTube video by GenomeTDCC

Martha Bulyk & Shubham Khetan just dropped a @nature.com paper redefining how we think about transcription factor binding, noncoding variants, and disease.
PADIT-seq, reveals that multiple overlapping binding sites drive TF occupancy and gene expression 🧪🧬💻👩‍🔬

Highlight 📽️https://youtu.be/45hdZ6R9fX4

🧪

Technology Development for Genome Analysis - Rob Mitra, PhD YouTube video by GenomeTDCC

What if doing something poorly could lead to something great?
Rob Mitra, @washugenetics.bsky.social, dives into the evolution of genome tech, short-read sequencing, and how his lab is fighting rising drug costs with innovation. 🧪🧬💻 #STS

📺 Watch the keynote: youtu.be/C8U5WDA9ri4
#genomics #Biotech

Sequencing a DNA analog composed of artificial bases YouTube video by GenomeTDCC

What if DNA didn’t use ACGT, but had PZSB instead? UW and FfAME researchers describe how they were able to sequence a synthetic DNA molecule made from 4 artificial bases in @natcomms.nature.com 🧪🧬🖥️

Check out the publication highlight on “ALIEN DNA” 👇
www.youtube.com/watch?v=S6tE...

Peeking Behind the Curtain: Technologies to Unveil RNA Modification Landscape - Kristin Koutmou, PhD YouTube video by GenomeTDCC

RNA isn’t just a messenger. It’s a modified masterpiece! 🧪
Over 10,000 sites in mRNA are chemically tagged, and we’re only beginning to understand why.

Kristin Koutmou @umich.edu explores the tools that reveal this hidden layer of gene regulation. Must-watch! 🎥👇
www.youtube.com/watch?v=s5Bt...
👩‍🔬🧬🖥️

Nanopore Sequencing Beyond ACGT - Andrew Laszlo, PhD YouTube video by GenomeTDCC

DNA beyond ACGT? But how do you sequence? 🧬 🖥️
youtu.be/GN6_Hc9tYow
Andrew Laszlo explains how #nanopore sequencing reads modified and synthetic bases like Z, P, B, and S by measuring ion current shifts instead of chemical pairing.

This technology could reshape synthetic biology and epigenetics. 🧪

Decoding the Centra Dogma with Single Molecule Sequencing - Winston Timp, Ph.D. YouTube video by GenomeTDCC

Winston Timp @timp0.bsky.social explains how single-molecule seq is transforming our understanding of gene regulation and epigenetic complexity 🧪🖥️🧬

www.youtube.com/watch?v=fj1_...

Direct detection of 5mC and 5hmC, supports cell-type deconvolution, and reveals tissue-specific regulatory features

From Typewriters to Code Editors: The History and Future of DNA Writing Tools - Sasha Levy, PhD YouTube video by GenomeTDCC

DNA has become programmable. 🧬🖥️
Sasha Levy (BacStitch DNA) discusses how #DNA engineering has evolved from basic cut-and-paste to programmable systems. Learn how enzymatic synthesis and in vivo assembly are shaping the future of synthetic biology 🧪 #STS
youtu.be/kSAm-2FbNus