Why is your separase such a big protease? Recent structural work explains a fundamental event during cell division, the timely and specific cleavage of the chromosomal cohesin complex by the protease separase.

that targets multiple substrate docking interactions & #separase specificity is harnessed, it could potentially lead to therapeutic applications in specific cancer types , & it might allow control over the growth & division of any eukaryotic pest or parasite.

www.science.org/doi/10.1126/...

#Medsky🧪 #immunosky #oncosky #microsky #drugdevelopment @science.org
#Separase, a large #protease (140–250 kDa in size), is characterised by its primary structure, which includes a substantial N-terminal regulatory region alongside its C-terminal catalytic domain.

Congratulations Andreas #Boland 's group and collaborators for you latest publication in Science Advances: Substrate recognition by human #separase @mocel.bsky.social @sciencesunige.bsky.social : www.unige.ch/medias/en/20...

Eliminating both #separase inhibition mechanisms –via securin and via cyclin B1-Cdk1– reveals absence of robust cohesin protection in metaphase II #oocytes
Katja Wassmann @meiosis-mom.bsky.social and colleagues
www.embopress.org/doi/full/10....

Differences in control of separase activity between meiosis and mitosis. Separase activity in mitosis is controlled by at least three different pathways: a specific protein inhibitor called securin; phosphorylation and binding to Cyclin/CDK1; and the Mad2/SGO2 complex. According to the results of the new study by Wetherall and colleagues [9], the Mad2/SGO2 complex does not play a role in separase control in oocytes.

Separase plays a key role in cleaving #cohesin complexes during cell division. Martin Anger explores a @plosbiology.org study showing that #separase activity is controled by #cyclin B/CDK1 & securin in #meiosis (and not SGO2, as in mitosis) 🧪 Paper: plos.io/3RAoccz Primer: plos.io/43L91UR

Differences in control of separase activity between meiosis and mitosis. Separase activity in mitosis is controlled by at least three different pathways: a specific protein inhibitor called securin; phosphorylation and binding to Cyclin/CDK1; and the Mad2/SGO2 complex. According to the results of the new study by Wetherall and colleagues [9], the Mad2/SGO2 complex does not play a role in separase control in oocytes.

Separase plays a key role in cleaving #cohesin complexes during cell division. Martin Anger explores a @plosbiology.org study showing that #separase activity is controled by #cyclin B/CDK1 & securin in #meiosis (and not SGO2, as in mitosis) 🧪 Paper: plos.io/3RAoccz Primer: plos.io/43L91UR

Differences in control of separase activity between meiosis and mitosis. Separase activity in mitosis is controlled by at least three different pathways: a specific protein inhibitor called securin; phosphorylation and binding to Cyclin/CDK1; and the Mad2/SGO2 complex. According to the results of the new study by Wetherall and colleagues [9], the Mad2/SGO2 complex does not play a role in separase control in oocytes.

Separase plays a key role in cleaving #cohesin complexes during cell division. Martin Anger explores a @plosbiology.org study showing that #separase activity is controled by #cyclin B/CDK1 & securin in #meiosis (and not SGO2, as in mitosis) 🧪 Paper: plos.io/3RAoccz Primer: plos.io/43L91UR