Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...

Whole-embryo #spatialtranscriptomics at subcellular resolution from #gastrulation to #organogenesis | Science www.science.org/doi/10.1126/...

Li et al. (*Nature*, 2026) have made monkey embryo models from stem cells to study late gastrulation! This could be a huge step for understanding primate development and early defects. Check out the video! #embryodevelopment #stemcells #gastrulation #monkeyembryo #research

youtu.be/hy3CRv64yIQ

🎊 Happy 2026 from #ASCBcourse!
Thanks to all former participants, speakers & future applicants! 🙏
One highlight: tracking stem cell-like behaviors in chick embryos during #gastrulation 🐣
Apply now 👉 shorturl.at/PyUHi
📆 June 22-July 3 @institutpasteur
#StemCells
@tajbakhshlab.bsky.social

1/2 Using #gastruloids @AnitaBanerjee19 Ram Sambasivan group find that Retinoic Acid gates the response of the epiblast to the Nodal:Eomes, Wnt:TbxT modules during mouse #gastrulation promoting the regionalization of the #PrimitiveStreak www.biorxiv.org/content/10.6...

Primer modelo de laboratorio desarrollado para estudiar la gastrulación en primates El model fet amb cèl·lules mare obre una via per estudiar la gastrulació, un procés crucial en el desenvolupament. A més, pot ajudar a estudiar els efectes de l'entorn i dels fàrmacs en el desenvolupa...

#Research
The first laboratory model to study primate #gastrulation developed

Made of monkey stem cells, the model can help understand this crucial process in development, study the effects of the environment and drugs, and identify the origin of many human diseases.
tuit.cat/Xszi8

Light-controlled embryos reveal power of mechanical forces in human development Only two weeks after fertilization, the first sign of the formation of the three axes of the human body (head/tail, ventral/dorsal, and right/left) begins to appear. At this stage, known as gastrulation, a flat and featureless sheet of cells folds into a living blueprint for the body, a fleeting transformation into axes and layers that will determine how every tissue develops. This all-important moment has, however, long stood beyond the reach of science, occurring too early and deeply within the uterus to study directly.

✨Within 2 weeks of life, a cellular blueprint folds, creating the human body’s axes! 🤯 This fleeting, hidden moment shapes *everything*. #Gastrulation 🧬

Source: phys.org/news/2025-11-embryos-rev...

On November 20, I will be participating in Cellular Dance, a multimedia ballet by D. Ibbett. Come and watch the dancers do the #gastrulation, and more! Don't worry, I will not be dancing, but will give a mini-lecture on cellular movement. At the Museum of Science Boston.
#DevBio #SciArt

Sox8 is essential for #vertebrate #gastrulation.

-> www.embopress.org/doi/full/10....

Sox8 is essential for vertebrate gastrulation | EMBO reports imageimageThe use of CRISPR Cas7-11 uncovers a role for sox8 in Xenopus gastrulation as a regulator of Wnt signaling. sox8 downregulation in the ventrolateral mesoderm disrupts blastopore closure and...

Congratulations to @sofiram.bsky.social and @artemiskorovesi.bsky.social on our last paper about the role of Sox8 in #xenopus #gastrulation

A link to the whole paper is here www.embopress.org/doi/full/10....

Looking forward to discussing why “genetics is not that simple” tomorrow in Lisboa. Thank you Fundacao Francisco Manues do Santos and GIMM for the opportunity
ffms.pt/en/agenda/al...
#NotInTheGenes #CellsRUs #Gastrulation

#Gastrulation reloaded
Thank you to @Jeromegros.bsky.social P. Tomancak, K. McDole, @Bensteventon.bsky.social L Solnica-krezel for a wonderful meeting to bring together @Institutpasteur@bsky.social a community whose work is growing in importance
#CONGASTRULATIONS A bientot

We are starting with THE LEGEND of the #gastrulation field - Ray Keller.

#cephalicfurrow forms and retracts to prevent tissue collision. Blocking it optogenetically not only causes buckling during #gastrulation, it also causes specific defects several hours after normal timeframe of retraction. More mysteries yet to be solved! (3/9)

5/6
Lumenogenesis coincides with circular expression of gastrulation marker Brachyury prior to AP-axis formation suggesting a novel role of Brachyury preceding #gastrulation

Further evidence that the #gastruloid system models the natural embryo from this spatiotemporal map of mouse #gastrulation
www.cell.com/cell-reports...
important as it provides a context for the, some times surprising, findings that the model is providing.

We found the most prominent alcohol-induced DNA methylation changes in the in vitro-cultured ectodermal cells (blue) compared to the endodermal (yellow) and mesodermal cells (green). Horizontal dashed lines indicate FDR<0.05.

Wallén & co expose #embryonicstemcells to alcohol during germ layer differentiation to study the effects of alcohol on the transcriptome, methylome and metabolome of embryonic germ layer cells during the developmentally crucial #gastrulation stage. doi.org/10.1242/dmm....
#PrenatalAlcoholExposure

🥁 New article 📢: #Mechanobiology of #development during #Drosophila #gastrulation using #Brillouin microscopy, now in @natcomms.nature.com : rdcu.be/ev6ZX
Collab. w/ @Prevedel_Lab @embl.org , Maria Leptin @marialep.bsky.social, @abhisha-thayambath.bsky.social, Julio Belmonte @ncstate.bsky.social

🚨 Hey #gastrulation folks!

The early bird registration and the abstract submission are coming up very soon.

Please register now for this nice #conference in @pasteur.fr, it will be super cool!
👇👇👇

Emergence of cellular nematic order is a conserved feature of gastrulation in animal embryos Nature Communications - The morphogenetic events that occur during gastrulation involve dramatic cell- and tissue-level changes. Here they show that propagation of nematic order, leading to...

Our paper finally got published @NatureComms rdcu.be/euofX. It was an interesting and fascinating journey with @RobertJHuebner1, @ThirumalaiArmy,
‪@jbwallingford.bsky.social‬, @GetYourChorion,
‪@peiferlabunc.bsky.social‬, and Jessica. #devbiol #nematic #gastrulation

GATA6 Mediates Endoderm and Mesoderm Progenitor Fate Driven by WNT and NODAL Signaling During gastrulation, NODAL and WNT signaling drives distinct gene regulatory networks (GRNs) to promote pluripotency exit, specify progenitor fate, and direct lineage differentiation. Here, we employ ...

Exciting new work by Miriam Gordillo and @toddevans24.bsky.social on signal-dependent lineage-promoting TF functions during mammalian gastrulation. www.biorxiv.org/content/10.1...
#development #gastrulation #stemcells

It's my pleasure. The work is very important and should, WILL change our view of #gastrulation which, as far as I am concerned, is driven by cells and where genes provide the tools that cells need to shape the body.

Two transcriptional modules that control mammalian #gastrulation that are functionally linked through their GRNs www.biorxiv.org/content/10.1... and paced by interactions between Wnt and Nodal signalling
Great collaboration with S Arnold and K McDole's labs #gastruloids

Very insightful summary of currently available approaches to model peri-implantation stages of human embryogenesis with stem cells. #development #embryogenesis #gastrulation.

It has been great to see the many possibilities of the system ay work: understanding #Gastrulation, #DiseaseModelling, #PhysicsofLivingMatter, #GeneRegulation and the promise of organ growth. Importantly a community emerging thru self organization and aiming to work together to create a field.

Great visit/talks from F. Corson on his work with @jeromegros.bsky.social
#Mechanobiology and #GRNs in avian #gastrulation www.nature.com/articles/s41... The output is clearly the product of an interaction between both but one has to start and rule; there is much that is #NotInTheGenes

#Gastrulation is not about cell types in UMAPs but about spatially organized dynamic structures over time

Statements on this topic should be accompanied by appropriate representations of the data rather than overrepresented and misleading drawings. While there is evidence for polarized initiation of TBXT expression in some of the structures, there is no evidence of #gastrulation.

Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts Xie et al. generate 4CL blastoids with morphology, transcriptional profiles, and DNA methylation patterns similar to those of blastocysts while maintaining gene imprinting and showing potential for po...

People should be more discerning when using the term gastrulation in #SCEMs as in this report from Cell Stem Cell www.cell.com/cell-stem-ce... there is no evidence for #gastrulation.

Spatial transcriptomic characterization of a Carnegie stage 7 human embryo - Nature Cell Biology Guo and colleagues characterize an intact Carnegie stage 7 human embryo at single-cell resolution in a spatially resolved manner.

Discovering early human development: Spatial transcriptomics of an intact Carnegie stage 7 embryo reveals single-cell insights, lineage diversification, and body axis formation. #Gastrulation #Embryo PMID:39794460, Nat Cell Biol 2025, @NatureCellBio doi.org/10.1038/s415...

Our results suggest that the regulatory hierarchy between Eomes and TbxT reflects two independent modules whose interactions and cross regulation determines the order and pace of #gastrulation. We also find a special role for Wnt signalling in controlling the pace of the process.