1/2 Using #gastruloids @AnitaBanerjee19 Ram Sambasivan group find that Retinoic Acid gates the response of the epiblast to the Nodal:Eomes, Wnt:TbxT modules during mouse #gastrulation promoting the regionalization of the #PrimitiveStreak www.biorxiv.org/content/10.6...

#quotes #books #booksky #excerpts #citations #howtogrowahuman #ball #embryo #primitivestreak #twins #personhood #embryology #development

Two important conclusions of the work are
1) that #gastruloids represent the #PrimitiveStreak and that is why they lack a Primitive Streak, they ARE the Primitive Streak.
2) events in the Primitive Streak are self organized.

Follwing findings of S. Arnold’s lab
www.cell.com/developmenta...
we substitute Activin (a Nodal surrogate) for Chiron and find that these condition lead to gastruloids that are complementary to Chiron driven ones. Together Chiron and Activin gastruloids span the length of the #PrimitiveStreak.

Inspired by findings of S. Arnold’s lab
www.cell.com/developmenta...
we substitute Activin (a Nodal surrogate) for Chiron and find that these condition lead to gastruloids that are complementary to Chiron driven ones. Together Chiron and Activin gastruloids span the length of the #PrimitiveStreak.