Mosaic gastruloids reveal a temporal restriction for developmental cell competition - Nature Cell Biology Frenster et al. utilize mosaic mouse gastruloids as a model of cell fitness and competition, identifying a temporal window between primed pluripotency and early gastrulation during which cell competit...

Because #gastruloids allow measurements, they can teach us about quantitative traits. Exploring #CellCompetiion @joshifrenster.bsky.social et al
www.nature.com/articles/s41...
Biology as a matter of #Genes #Cells and #Numbers but of much that is #NotInTheGenes

Mosaic gastruloids reveal a temporal restriction for developmental cell competition - Nature Cell Biology Frenster et al. utilize mosaic mouse gastruloids as a model of cell fitness and competition, identifying a temporal window between primed pluripotency and early gastrulation during which cell competit...

🥳 I am happy to share our latest manuscript published in @natcellbio.nature.com We use #Gastruloids to study #CellCompetition during early mammalian development and find not only that this is highly pronounced in our system but also tightly restricted in time. (1/12) www.nature.com/articles/s41...

Frenster Lab | Cell Competition Dynamics We study Cell Competition during Embryonic Development using 3D Gastruloids at the University of Freiburg. We view cells as interactive societies in development and cancer. Research, stem cells, Gastr...

The Frenster Lab is here! 🍾 I am so excited to start my #EmmyNoether funded group at @uni-freiburg.de this summer. Our group studies #CellCompetition dynamics during embryonic development using #gastruloids from multiple species. Thanks to the @dfg.de for creating this opportunity! FrensterLab.com

Sheep and pig #gastruloids, @IftachN: www.biorxiv.org/content/10.6...
The accumulating knowledge of the relationship between #SCBEMs and #Embryos, allow us to learn about species similarities and differences in gastrulation and body plan elaboration.

Metabolic Origins: Steering of early developmental fate #MetabolismMondays - the Node All the world's a metabolic dance, early career scientists are leading the way! Emerging perspectives in metabolism Dr Kristina StapornwongkulX:

@kstapornwongkul.bsky.social , #newPI at @viennabiocenter.bsky.social - discussing the metabolism of embryonic development using #gastruloids. #embryogenesis
#DevBio #stemcell #glucosemetabolism

1/2 Using #gastruloids @AnitaBanerjee19 Ram Sambasivan group find that Retinoic Acid gates the response of the epiblast to the Nodal:Eomes, Wnt:TbxT modules during mouse #gastrulation promoting the regionalization of the #PrimitiveStreak www.biorxiv.org/content/10.6...

At InSDB-SD2026 in IISER Berhampur
Great Day 2 morning session with a highlight from @InamdarManeesha. on the use of #SCbEM in the study of #HumanReproduction within the CReATE initiative @DBT_inStem
Using #Gastruloids for human health

Thank you @InamdarManeesha for hosting my visit to CREATE, an initiative within @DBT_inStem devoted to advancing knowledge and empowering innovation on #Human#Development
instem.res.in/research/maj...
an amazing project
#Fertility #Blastoids #Gastruloids

#N2B27 is an acronym that creates a lot of trouble in labs growing #gastruloids because of variability. Building on earlier work from A. Smith’s lab, my colleagues decided to address the root of the issue shorturl.at/QM4C6
and see their views on the work shorturl.at/dYB9X

@campaslab.bsky.social @jesseveenvliet.bsky.social labs use #gastruloids to explore axial extension in mammalian embryos
www.biorxiv.org/content/10.1...
They find novel mechanisms involving and interplay of proliferation and mechanical constraining.
#NotInTheGenes #CellsRUs

Promotional graphic for a special issue of Disease Models & Mechanisms titled "In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery." The left side of the image contains text announcing the call for papers, edited by Vivian Li, Austin Smith, and Joseph Wu, with a submission deadline of 3 November 2025. The right side features a vibrant, microscopic image of biological tissue or cell structures in vivid pink, blue, and yellow hues, representing the complexity of in vitro disease models. The design combines scientific detail with visual appeal to attract submissions for the issue.

Call for papers: In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery

Deadline approaching: Monday 3 November 2025

journals.biologists.com/dmm/pages/in...

#Biology #Research #Disease #Discovery #Organoids #Tumours #Gastruloids #Assembloids

A protocol for the robust generation of human #gastruloids, an important optimization needed by the field. This is not only a #protocol but also a reasoning behind it and a study of the initial conditions
www.biorxiv.org/content/10.1...

#gastruloids by the shores of Lake Lehman, Lausanne 2017
The start of something
@EPFL @geneticscam.bsky.social

📣 New preprint! We present SpinePy, a modular framework that enables automated 3D spatiotemporal quantification of #gastruloids & other multicellular in vitro systems. Spearheaded by @cryaaa.bsky.social @mpi-cbg.de. Check out his thread 👇 & the paper:
www.biorxiv.org/content/10.1...

Honouring our friend Dr. Svetlana Jovanic who passed away after battling cancer for almost 3 years.

a passionate researcher
a keen photographer
a generous and loyal friend.

She investigated #zebrafish & #gastruloids using #lightsheet #microscopy.

We will not forget her.

If you are interested in #DevBio, #organoids, #gastruloids or #CRISPR, check out the tweetorial to our new preprint on uncovering novel regulators of body plan formation in gastruloids using single cell CRISPR screens!

A big thank you to all co-authors that made this paper possible!

What happens when you plate #gastruloids at different times on different subtstrates is that we learn about cells, pattern formation and gastrulation. Excellent experiments from G. Serrano and ‪@bensteventon.bsky.social‬ raising interesting questions www.biorxiv.org/content/10.1...
#CellsRUs

There is an echo here of the situation in #gastruloids where it is possible to see un uncoupling between #GRNs and #CRNs (cell regulatory networks) www.sciencedirect.com/science/arti...
#CellsRUs

Computational biologist / Bioinformatician - Computational biologist / Bioinformatician detail

Great opportunity for a bioinformatician to join an amazing lab in #Amsterdam #JobOpportunity #bioinformatics #gastruloids

www.sanquin.org/working-at/v...

But there is much more. The experiments r beautiful & follow on the wake of the long standing interest/contributions of @arjunraj.bsky.social to this difficult issue of the role that these pervasive heterogeneities play in pattern formation. Good to see #gastruloids contributing to it.

Two new preprints from the @arjunraj.bsky.social‬ on #gastruloids. Both excellent. Exploring the relationship between macroscopic reproducibility v microscopic heterogeneity. Stunning experiments and much to think about
biorxiv.org/content/earl...
biorxiv.org/content/earl...

We’re hiring! 🚀 Junior Lab Tech / PhD student (cell & mol-bio) to push our Calipers tech into 3D #gastruloids. Must already have Italy work permit (sorry, can’t sponsor). Love stem cells + CRISPR? DM or send CV by 31 Aug 2025. #hiring #StemCells

Metabolic Origins: Steering of early developmental fate #MetabolismMondays - the Node All the world's a metabolic dance, early career scientists are leading the way! Emerging perspectives in metabolism Dr Kristina StapornwongkulX:

#MetabolismMondays
Meet @kstapornwongkul.bsky.social, #newPI at @imbavienna.bsky.social @vbcscitraining.bsky.social, alumni from @viktri08.bsky.social @embl.org - discussing metabolism of embryonic development using #gastruloids.
#theNodeCorrespondents #ecr @the-node.bsky.social #DevBio #stemcell

Excellent work supporting #modularity of the mammalian #embryo, a role for #hypoxia & how development exploits these features. It shows what we can learn from assemblies of #gastruloids @ spatio-temporal coordination of the modules in AP organization. Putting modules together, extremely informative

The modularity of the mammalian #embryo in display. Controlled assembly of classic #gastruloids and uncommitted precursors in #hypoxia, patterns the AP axis
www.biorxiv.org/content/10.1...
Beautiful & insightful from @bulutkarslioglu.bsky.social‬ group. Building models to learn and learning.

In which we discuss the homologies between amphibian and mammalian organizers from the perspective of #gastruloids with special relevance to recently described A and C gastruloids as containing Spemann/Mangold and Trunk/Tail organizers www.sciencedirect.com/science/arti...

It is indeed good to see how #gastruloids provide a fresh look at old and challenging questions of #DevBio and also, hopefully, paths to answers. Certainly to new experimental approaches.

Two transcriptional modules that control mammalian #gastrulation that are functionally linked through their GRNs www.biorxiv.org/content/10.1... and paced by interactions between Wnt and Nodal signalling
Great collaboration with S Arnold and K McDole's labs #gastruloids

SUMO – SUpervised MOrphogenesis – Supervised Morphogenesis

We updated our website supervised-morphogenesis.eu! New links to data-sets, code & publications. Check it out! #EIC #EICPathfinder #HorizonEU #gastruloids #embryomodels #EngineeredLivingMaterial @bgerratana.bsky.social

NEW PAPER ALERT!!

🥚And a new powerful tool for modeling early human development!

@antonio-scialdone.bsky.social ’s lab @www.helmholtz-munich.de & A. Surani’s lab at University Cambridge uncover key insights into early #humandevelopment with 3D human #gastruloids.

Read our news: shorturl.at/7FjGT