Why some cancer-fighting immune cells lose their strength inside tumours Mitochondria are key to powering the immune defenders called dendritic cells.

Why some #cancer-fighting #immunecells lose their #strength inside #tumours

#Mitochondria are key to #powering the #immune #defenders called #dendriticcells

www.nature.com/articles/d41...

Aberrant hormone receptors regulate a wide spectrum of endocrine tumors Aberrant G-protein coupled receptor (GPCR) expression is highly prevalent in cortisol-secreting primary bilateral macronodular adrenal hyperplasia (PBMAH) and unilateral adenomas. The aberrant express...

Aberrant or ectopic hormone receptors and their ligands play a much wider role than appreciated in regulating hormonal secretion via endocrine, paracrine, and autocrine modes in many #endocrine #tumours thelancet.com/journals/lan...
#GPCRs

#MedSky #EndoSky #OncSky

dianova Anti-TIGIT (Hu) Clone TG1 is the first monoclonal antibody detecting #TIGIT in routine #FFPE tissue specimen by #IHC.

Validated for the identification of TIGIT positive #Tcells infiltrating human #tumours under pathological conditions.

www.stratech.co.uk/p...

Researchers praise ‘stunning’ results of new prostate cancer treatment Early trials of the drug VIR-5500 showed it shrinking tumours in some patients

A new #ProstateCancer drug is showing really promising early results 🧪🙂 In trials, it helped shrink #tumours in some patients and caused only mild side effects, improving treatment options in the future. This kind of breakthrough could give people more time and better quality of life ❤️

Five projects share £100m UK-US Cancer Grand Challenges fund Five scientific teams will receive up to £20m each in a new round of funding under the UK and US Cancer Grand Challenges initiative.

#CancerGrandChallenges #CRUK #NCI #UK #USA #oncology #cancer #ATLAS #INSERM #autoantibodies #tumours #REWIRECAN #UCLCancerInstitute #ILLUMINE #NetherlandsCancerInstitute #darkproteome #proteins #immunotherapies #antigenicmarkers #CAUSE #InteroCANCEption #FrancisCrickInstitute
zurl.co/P9eTF

A Long #History of Almost Nothing : Medium

How Can #Infinity Come in Many Sizes? : Quanta Mag

Ultra-sensitive #CAR-T #Cells eliminate hard-to-treat #Tumours in #Mice : Nature

Latest #KnowledgeLinks

knowledgezone.co.in/resources/bo...

First ever inhalable gene therapy for cancer gets fast-tracked by FDA A gene therapy that patients breathe in has been found to shrink lung tumours by inserting immune-boosting genes into surrounding cells

In case you missed it...
First ever inhalable gene therapy for cancer gets fast-tracked by FDA

A gene therapy that patients breathe in has been found to shrink lung tumours by inserting immune-boosting genes into surrounding cells

#lungcancer #genetherapy #treatment #cancer #inhalable #tumours

Endocrine and metabolic determinants of cardiometabolic risk in mild autonomous cortisol secretion MACS represents a metabolic continuum between NFAT and adrenal CS. Increased activity of the adrenal enzyme 11β-hydroxylase (CYP11B1), which catalyses key steps in cortisol and 11-oxygenated androgen ...

Published in @ebiomedicine.bsky.social

Endocrine and metabolic determinants of cardiometabolic risk in mild autonomous cortisol secretion www.thelancet.com/journals/ebi...
non-functioning #adrenal #tumours
#Cushing's syndrome
#OpenAccess

#MedSky #EndoSky

More liberal use of bilateral adrenalectomy for bilateral adrenal tumours with cortisol excess Bilateral adrenal tumours with cortisol hypersecretion represent a common clinical challenge. Adrenal incidentalomas are detected in approximately 4% of abdominal imaging studies, with prevalence incr...

Linked Comment by Quan-Yang Duh & Michelle B Mulder:
More liberal use of bilateral adrenalectomy for bilateral adrenal tumours with cortisol excess thelancet.com/journals/lan...
#bilateral #adrenal #tumours #adrenalectomy #cortisol excess

#MedSky #EndoSky #OncSky

Effect of surgical versus conservative management on cardiovascular outcomes in patients with bilateral adrenal tumours and cortisol excess: an international, retrospective cohort study Although mortality and cardiovascular event rates were similar across treatments, surgery led to better biochemical control and more favourable comorbidity outcomes.

Although mortality and cardiovascular event rates were similar across treatments, surgery led to better biochemical control and more favourable comorbidity outcomes thelancet.com/journals/lan...
#bilateral #adrenal #tumours #adrenalectomy #cortisol excess

#MedSky #EndoSky #OncSky

Adrenal tumour imaging: clinical, molecular, and radiomics perspectives Adrenal tumours have become a common incidental finding in the radiological evaluation of patients. Estimates suggest that 1–10% of the general population currently harbours an adrenal tumour, peaking...

For much of the 20th century, the diagnosis of #adrenal #tumours, defined as enlarged or atypical-appearing adrenal lesions that can be benign or malignant, relied on clinical suspicion of large palpable masses, hormonal manifestations, or autopsy findings www.thelancet.com/journals/lan...

#EndoSky

🔬Dianova Anti-TIGIT (Hu) Clone TG1 is the first monoclonal #antibody detecting #TIGIT in routine #FFPE tissue specimen by #IHC

Validated for the identification of TIGIT positive #Tcells infiltrating human #tumours under pathological conditions

🔗www.stratech.co.uk/p...

Adapting eye-laser technology to remove cancer Researchers at Heriot-Watt University and the University of Edinburgh have carried out one of the most detailed studies to date of how deep-ultraviolet, ultrashort-pulsed lasers interact with soft bio...

Scientists from 🏴󠁧󠁢󠁳󠁣󠁴󠁿 @heriotwattuni.bsky.social and @edinburgh-uni.bsky.social have shown that a type of #laser similar to the one currently used in routine eye #surgery could one day help surgeons remove unwanted tissues, such as #tumours, with unprecedented accuracy.

More liberal use of bilateral adrenalectomy for bilateral adrenal tumours with cortisol excess Bilateral adrenal tumours with cortisol hypersecretion represent a common clinical challenge. Adrenal incidentalomas are detected in approximately 4% of abdominal imaging studies, with prevalence incr...

Quan-Yang Duh & Michelle B Mulder comment on:
More liberal use of bilateral #adrenalectomy for bilateral #adrenal #tumours with #cortisol excess thelancet.com/journals/lan...
#cardiometabolic #morbidity #mortality
#adrenal crises

#MedSky #EndoSky #OncSky

Effect of surgical versus conservative management on cardiovascular outcomes in patients with bilateral adrenal tumours and cortisol excess: an international, retrospective cohort study Although mortality and cardiovascular event rates were similar across treatments, surgery led to better biochemical control and more favourable comorbidity outcomes.

New—Effect of surgical versus conservative management on #cardiovascular outcomes in patients with #bilateral #adrenal #tumours and #cortisol excess: an international, retrospective cohort study thelancet.com/journals/lan...
#cardiometabolic #morbidity #mortality
#adrenal crises

#MedSky #EndoSky

Adrenal tumours are commonly encountered in every endocrinology practice and related subspecialties nowadays, and require the most accurate evidence-based management, treatment, and follow-up www.thelancet.com/journals/lan...
#adrenal #tumours

#MedSky #EndoSky #OncSky

In recent years, and even more since its legalization in several jurisdictions, cannabis and the endocannabinoid system have received an increasing amount of interest related to their potential exploitation in clinical settings. Cannabinoids have been suggested and shown to be effective in the treatment of various conditions. In cancer, the endocannabinoid system is altered in numerous types of tumours and can relate to cancer prognosis and disease outcome. Additionally, cannabinoids display anticancer effects in several models by suppressing the proliferation, migration and/or invasion of cancer cells, as well as tumour angiogenesis.

#AntiCancer Potential of #Cannabinoids, #Terpenes, and #Flavonoids Present in 🌱 #Cannabis

https://pmc.ncbi.nlm.nih.gov/articles/PMC7409346/

In #cancer, the #endocannabinoidsystem is altered in numerous types of #tumours and can relate to cancer prognosis […]

[Original post on mastodon.social]

Aberrant hormone receptors regulate a wide spectrum of endocrine tumors Aberrant G-protein coupled receptor (GPCR) expression is highly prevalent in cortisol-secreting primary bilateral macronodular adrenal hyperplasia (PBMAH) and unilateral adenomas. The aberrant express...

Regulation of #endocrine #tumours by aberrant GPCR is not restricted to cortisol-secreting adrenal lesions, but also occurs in tumours of several other organs www.thelancet.com/journals/lan...
G-protein coupled receptors #GPCRs

MIT scientists strip cancer of its sugar shield Scientists at MIT and Stanford have unveiled a promising new way to help the immune system recognize and attack cancer cells more effectively. Their strategy targets a hidden “off switch” that tumors ...

Exciting news! MIT & Stanford scientists just revealed a breakthrough way to strip away cancer’s “sugar shield” – helping the immune system spot & attack #tumours more effectively. Hope for better treatments ahead!
www.sciencedaily.com/releases/202...
#CancerResearch #Immunotherapy #TCSC

Creatine: The bodybuilding supplement that boosts brainpower Creatine is often taken by people looking to build muscle. Now scientists are investigating the effects this chemical has on our cognition and mood.

www.bbc.com/future/artic...
#CreatinePowder #Supplement #Muscles #ShortTermMemory #Boost #Research #HealthBenefits #CognitiveFunction #AntiOxidant #AntiDepressent #ProfessorDouglasKalman #NeuroTransmitters #Vegans #Alzheimers #Covid #EnergySource #Reproduction #WomanStudies #MenoPause #Tumours

Adrenal tumours are commonly encountered in every endocrinology practice and related subspecialties nowadays, and require the most accurate evidence-based management, treatment, and follow-up www.thelancet.com/journals/lan...
#adrenal #tumours

#MedSky #EndoSky #OncSky

🚨 Good news! Registrations are open for our 1st #educational Webinar on latest advances in #genetics of #adrenal #tumours. Expect lectures from excellent international speakers and case presentations from early careers. Programme & links: ensat.org/event-6456168 #EndoSky #MedSky

Adrenal tumour imaging: clinical, molecular, and radiomics perspectives Adrenal tumours have become a common incidental finding in the radiological evaluation of patients. Estimates suggest that 1–10% of the general population currently harbours an adrenal tumour, peaking...

For much of the 20th century, the diagnosis of #adrenal #tumours, defined as enlarged or atypical-appearing adrenal lesions that can be benign or malignant, relied on clinical suspicion of large palpable masses, hormonal manifestations, or autopsy findings www.thelancet.com/journals/lan...
#EndoSky

ESR Bridges: imaging and treatment in brain tumours—a multidisciplinary view - European Radiology European Radiology -

🧠 In this article, diffuse gliomas - among the most lethal #brain #tumours - are explored through the lens of #imaging, which is central to every step of management, from diagnosis and surgery to radiotherapy and follow-up.

📣 2 PhD student positions open in the Medical Image Analysis Laboratory (MIAL) of Meritxell Bach Cuadra @cibm.bsky.social @unil.bsky.social #chuv

on #pediatric #brain #tumours and
on #MultipleSclerosis #MS

More info 🔗 cibm.ch/open-positio...

Aberrant or ectopic hormone receptors and their ligands
play a much wider role than appreciated in regulating
hormonal secretion via endocrine, paracrine, and
autocrine modes in many endocrine tumours www.thelancet.com/journals/lan...
#GPCRs #endocrine #tumours

#MedSky #EndoSky #OncSky

For much of the 20th century, the diagnosis of #adrenal #tumours, defined as enlarged or atypical-appearing adrenal lesions that can be benign or malignant, relied on clinical suspicion of large palpable masses, hormonal manifestations, or autopsy findings www.thelancet.com/journals/lan...
#EndoSky

dianova Anti-TIGIT (Hu) Clone TG1 is the first monoclonal antibody detecting #TIGIT in routine #FFPE tissue specimen by #IHC. Validated for the identification of TIGIT positive #Tcells infiltrating human #tumours under pathological conditions.

www.stratech.co.uk/products/DIA...

#diagnostics

👏Looking frwd to talk: #Multiomics #spatial context in #Cancer: from #immunobiology to next-gen #therapies @myesmo.bsky.social (cslide.ctimeetingtech.com/coasis_21467...)
🔥Will reveal best-in-class #trispecific #macrophage #activator #antibody capable of >90% inhibition of #immunoresistant #tumours

#Adrenal #tumours are commonly encountered in every endocrinology practice & related subspecialties nowadays, & require the most accurate evidence-based management, treatment, and follow-up thelancet.com/journals/lan...
#phaeochromocytoma #paraganglioma #adrenocortical #carcinoma

#MedSky #EndoSky