fineartamerica.com/featured/thr...
#Mice #Stage #Blind #Humor

Just a couple of cute mice skipping around like they know what they’re doing

#mice #furry #cute #anthro #animals

Here's a Reader's Digest #cartoon to mark my return... #mice #holiday

🐱Cat Toy Page 15🐭
Final page for issue one!
We finished issue one!
Thank you so much for the support!

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#sizesky #giant #macrofurry #Macro #NSFW #furry #sex #cat #NonbinaryPred #vore #dick #penis #mice #mouse

A small pink wicker basket with multi-colored crinkle paper in it. Near the rim of the basket some of the paper is parted to show an albino mouses white eyes peeking out.

ru peekin...lil easter egg that she is
#mypets #mice

MultiSearch Tag Explorer MultiSearch Tag Explorer - Explore tags and search results by aéPiot - aéPiot: Independent SEMANTIC Web 4.0 Infrastructure (Est. 2009). High-density Functional Semantic Connectivity with 100/100 Trust...

#MICE #FOLLIES 1960 #FILM
multi-search-tag-explorer.aepiot.com/advanced-sea...
#SULU #ARCHIPELAGO
multi-search-tag-explorer.aepiot.com/advanced-sea...
aepiot.ro

check out this fantastic #bramblyhedge boxed #clock in stock
nivagcollectables.co.uk/p/8909
#mice #gift #giftidea #nursery

Tidying up our cellar/utility room I find a wooden box with a corner nibbled off, and inside that a bag with a hole, and inside that another box that once held rat poison. #mice

🐱Cat Toy Page 14🐭
Felix fed their tummy and now their feeding their booty.

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#sizesky #giant #macrofurry #Macro #NSFW #furry #sex #cat #NonbinaryPred #vore #dick #penis #mice #mouse

A tiny mouse made of wool sitting on a hand. He has droopy ears and is holding. Red heart.

A tiny mouse made of wool sitting on a hand. He has droopy ears and is holding a Red heart. Made using the needle felting technique.

I made a tiny mouse! #mice #needlefelting

Nettles peeking out. She looks a bit blurry as she's close to the camera. She's a grey and white patterned mouse.

Nettles peeking out. Much clearer photo as she's chilling partially outside a cardboard canister hide. She's a grey and white patterned mouse.

Nettles peeking out. She looks a bit more raring to go. She's a grey and white patterned mouse.

Nettles peeking out. She's back to feeling sleepy as she blinks halfway. She's a grey and white patterned mouse.

Sleepyhead Nettles 🥺🥺🥺
#Mice #Mouse #Pet

Ketogenic Diet Attenuates Late Gestational Sleep Deprivation-Induced Aggression in Adult Offspring #mice Publication date: Available online 26 March 2026 Source: Physiology & Behavior Author(s): Fei Zhou, Xi Yu, Miao Gong, Xueyong Yin, Yunluo Li, Yifei Sang, Xiao Liu, Yiran Liu, Shu Yan, Li Song, Ye Zhao, Haishui Shi

Ketogenic Diet Attenuates Late Gestational Sleep Deprivation-Induced Aggression in Adult Offspring #mice Phys&Beh

Integrating supervised and unsupervised machine learning for #behavior segmentation reveals latent frailty signatures and improves aging clocks in isogenic and outbred #mice Manual frailty index (FI) assessment in mice is a strong predictor of morbidity and mortality, and is frequently used in mechanistic and translational geroscience. However, it is labor-intensive, requires expert training, and is vulnerable to scorer variability. We previously developed a visual frailty index (vFI) that objectively predicts age and frailty using expert-defined, supervised behavioral features extracted from open-field videos. However, relying solely on human-defined features may miss subtle, latent behavioral signatures of aging. Here, we test whether unsupervised behavioral discovery using Keypoint-MoSeq (KPMS) could uncover these hidden signatures and improve the prediction of aging-related outcomes. Using a large dataset of isogenic C57BL/6J (B6J) and genetically diverse Diversity Outbred (DO) mice, we find that unsupervised features are highly predictive of chronological age, biological frailty, and the proportion of life lived. Notably, while supervised features overall outperformed unsupervised features in these tasks, combining both feature sets yielded the highest predictive accuracy across all outcomes. Despite these improvements, models trained on either feature set failed to generalize across strains, confirming that behavioral manifestations of aging are strongly population-specific. These findings demonstrate that supervised and unsupervised machine vision provide complementary information, establishing a highly sensitive, scalable, and non-invasive framework for objective and scalable geroscience in rodents.

Integrating supervised and unsupervised machine learning for #behavior segmentation reveals latent frailty signatures and improves aging clocks in isogenic and outbred #mice bioRxivpreprint

EARA | News - Drug behind Viagra improves rare childhood disease A study in Germany has identified a potential treatment for Leigh syndrome, with early positive results in children supported by findings in cells from patients, mice and pigs.  Leigh syndrome is a…

A study led by EARA member Charité Berlin has identified a potential treatment for Leigh syndrome, with early positive results in children supported by findings in cells from patients, mice and pigs.
www.eara.eu/news/drug-be...
#AnimalResearch #mice #pigs #nams #TranslationalResearch

#mICE

An albino white mouse in a orange tent-shaped fabric den. Held aloft inside the interior of a vehicle.

the princess Rutile is booked in for her surgery on Wednesday!! You got this tiny baby angel!!!!
#mypets #mice

Should the industry start to move away from the use of the term Advanced Persistent Threat as a way of describing an intruder? If media reporting labels everything from highly motivated financial threats to nation-state actors as "APT", maybe it's time the term is retired.

#APT #cybersecurity #MICE

Well I can’t complain about the weather. I can’t really complain about the weather even if I actually is a bit disappointed at it :-) Nice but cold morning and we were supposed to have sunshine for a big part of the day but l…

The weather wasn't as nice as I had hoped for but actually not bad at all, still I'm a bit disappointed 😀

#spring #warm #cloudy #mice #roedeer #nature #flowers

New blog: thecottagebythecranelake.blog/2026/03/26/w...

Can a mouse be cloned indefinitely? Decades-long experiment has answers Repeated cloning from a single mouse failed after 58 generations. Researchers say harmful DNA changes are to blame.

"After 20 years, 58 generations and more than 30,000 cloning attempts, a team of researchers has hit the limit on the number of times a single mouse can be serially re-cloned."

#Cloning #Mammals #Mice

Integrating supervised and unsupervised machine learning for #behavior segmentation reveals latent frailty signatures and improves aging clocks in isogenic and outbred #mice Manual frailty index (FI) assessment in mice is a strong predictor of morbidity and mortality, and is frequently used in mechanistic and translational geroscience. However, it is labor-intensive, requires expert training, and is vulnerable to scorer variability. We previously developed a visual frailty index (vFI) that objectively predicts age and frailty using expert-defined, supervised behavioral features extracted from open-field videos. However, relying solely on human-defined features may miss subtle, latent behavioral signatures of aging. Here, we test whether unsupervised behavioral discovery using Keypoint-MoSeq (KPMS) could uncover these hidden signatures and improve the prediction of aging-related outcomes. Using a large dataset of isogenic C57BL/6J (B6J) and genetically diverse Diversity Outbred (DO) mice, we find that unsupervised features are highly predictive of chronological age, biological frailty, and the proportion of life lived. Notably, while supervised features overall outperformed unsupervised features in these tasks, combining both feature sets yielded the highest predictive accuracy across all outcomes. Despite these improvements, models trained on either feature set failed to generalize across strains, confirming that behavioral manifestations of aging are strongly population-specific. These findings demonstrate that supervised and unsupervised machine vision provide complementary information, establishing a highly sensitive, scalable, and non-invasive framework for objective and scalable geroscience in rodents.

Integrating supervised and unsupervised machine learning for #behavior segmentation reveals latent frailty signatures and improves aging clocks in isogenic and outbred #mice bioRxivpreprint

EARA | News - Brain Prize winners assert animal research as irreplaceable 2025 Brain Prize winners, Michelle Monje of Stanford Medicine and Frank Winkler of Heidelberg University Hospital, made clear that animal research remains essential to their work.  In an FENS…

In a @fens.org article, based on an interview with @tvvde.bsky.social, neuroscientists Michelle Monje and Frank Winkler, the 2025 Brain Prize winners, made clear that animal research remains essential to their work.
🔗 www.eara.eu/news/brain-p... #AnimalResearch #Brain #BrainPrize #neuroscience #mice

#mICE

Small Mammal Conservation Conference, September 2026 Sofia, Bulgaria https://smcc.habitatfoundation.org/ Photo: Striped field-mouse (Rollin Verlinde / Vilda)

No rodents = no food for many birds of prey. That's why in the LIFE for falcons project, the focus is on purchasing and managing habitat for #rodents and reintroducing rodents to areas where they've disappeared.
smcc.habitatfoundation.org

#discovermammals #mouse #rat #mice #vole #Bulgaria #SMCC

#mICE

A picture of Daisy with her mouse friends Sally and Simon.

#cartoon #originalcharacter #drawing #mouse #flower #mice #cuteb #friends #cartoonart #artwork #art #cuteart #cartoonart

EARA | News - ‘Old’ gut bacteria cause memory decline in mice Researchers in the US have shown that age-related changes in gut bacteria composition can directly influence memory in mice.  There is growing evidence suggesting that the gut microbiome—the…

Researchers from Stanford Medicine have shown that age-related changes in gut bacteria composition can directly influence memory in mice.
🔗 www.eara.eu/news/old-gut...
#AnimalResearch #mice #ageing #microbiota #brain #memory #gut #gutbrain #research #science #sciencenews

大阪梅田発、新たなMICE体験を提供するアプリ『AIDA UMEDA』が始動 大阪梅田エリアのMICE体験を最大化するアプリ『AIDA UMEDA』が登場。参加者や主催者に新しい価値を提供する機能が満載です。

大阪梅田発、新たなMICE体験を提供するアプリ『AIDA UMEDA』が始動 #大阪府 #大阪市 #MICE #大阪梅田 #AIDA_UMEDA

大阪梅田エリアのMICE体験を最大化するアプリ『AIDA UMEDA』が登場。参加者や主催者に新しい価値を提供する機能が満載です。

Contributions of superior colliculus and primary visual cortex to visual spatial detection in freely moving #mice In freely moving mice performing a closed-loop visual spatial detection task, Kim et al. show that superior colliculus (SC) activity is more sustained and more predictive of reaction time than primary visual cortex (V1) activity. Silencing the SC produces stronger impairments in visual spatial detection than silencing V1.

Contributions of superior colliculus and primary visual cortex to visual spatial detection in freely moving #mice CurrentBiology

Pan Pacific Hotels Group Launches Campaign to Transform Business Events Experience Pan Pacific Hotels Group has launched the 'Every Meeting Matters' campaign to enhance the MICE experience, focusing on wellness, sustainability, and technology.

Pan Pacific Hotels Group Launches Campaign to Transform Business Events Experience #Singapore #Campaign #MICE #Pan_Pacific

Countless scientists and at least a dozen high-concept sci-fi comedies over the past 30 years have speculated on the potentially degrading effect of making clones out of other clones, ad infinitum. The same year that researchers first cloned Dolly the sheep, the Michael Keaton comedy _Multiplicity_ (1996) compared it to the visual static added when your office Xerox machine makes a copy of a copy of a copy. Now, biologists in Japan have determined what they believe might actually be a hard limit on just how many successful, viable clones can be made from generations of past clones. Drawing on 20 years of their own research serially cloning mice, the team had hoped to make infinite clones of clones with the help of a promising reagent additive, trichostatin A, which helps to suppress the activity of genetic mutations during the cloning process. “We initially concluded that serial cloning could be continued indefinitely,” Teruhiko Wakayama and his colleagues noted in their new study, published Tuesday in the journal Nature Communications, “since the success rate improved slightly with each successive generation.” It was all smooth sailing, in fact, until the researchers started cloning their 25th through 27th generations of mice. But by the 58th generation, according to Wakayama’s team, the mice did not even survive for more than a day. ## Thousands of healthy clones Scientists have used trichostatin A as an antifungal antibiotic, but it can also inhibit the functioning of certain enzymes in mammals, like mice and also humans. For Wakayama and his team’s purposes, however, the compound also acts as what they call an “epigenetic modification reagent,” suppressing unwanted DNA transcription factors, or the enzymatic proteins that activate pieces of the potentially harmful mutations in a mouse’s genetic code during cloning. “More than 1200 cloned mice were produced from a single original donor mouse,” according to Wakayama, a developmental biologist who works for the University of Yamanashi’s Advanced Biotechnology Center, and his coauthors. And, surprisingly, most fared well before the drop-off. “Late-generation clones except [the] last generation that survived to birth were notably healthy,” the team reported, “with normal lifespans, despite carrying numerous deleterious mutations.” These very re-cloned clones, in fact, also developed with most of their reproductive organs healthy and intact, the researchers found, “raising the possibility that subsequent generations could be produced via sexual reproduction.” Their study suggests that further experimentation with reagents like trichostatin A might further extend cloning deeper into successive generations. They found the compound remained effective, even as they worked with later, more difficult generations of their clones. The success rate for implanting a clone donor cell nucleus into an egg was three times more successful for even 51st generation cloned mice when trichostatin A was used (a 5.4% success rate), as opposed to without the reagent (1.6%). ## A steep drop Wakayama’s team did, however, measure some hard facts about the number of natural mutations that emerged between each successive generation of their clones. Each new round of cloned mice acquired about 70 small “single-nucleotide variants” and about 1.5 additional and more substantial “structural variants” to their genetic code. While this rate was not out of the ordinary, those structural variations built up over multiple rounds of re-cloning. Over time, they found, “the build-up of harmful variants appears to have outweighed adaptive effects,” without the chromosomal recombination effects of sexual reproduction to filter out the large and potentially harmful genetic variations. Here too, there was evidence that even a slight pivot back to sexual reproduction could course-correct these issues. The researchers’ late-generation cloned mice, for example, were born with noticeable abnormalities in their placenta, but when those mice mated naturally, their offspring’s placenta had returned to normal. Theories abound for why mammals and other creatures evolved to reproduce sexually, including a case that it helped earlier species protect themselves from parasites by offering robust genetic diversity. Wakayama and his group’s own journey to the far end of genetic recloning might suggest mammals need to mate to protect their genome from going stale over time.

How many times can you clone a clone? @Gizmodo has the results of a 20-year study of mice by biologists in Japan.

https://flip.it/g-AFg4

#Science #Genetics #Biology #Mice