Thank you. My colleagues and I are pleased that we developed a system that works and that 11 years and over 100 papers #gastruloid papers later, what we felt in the final paragraph of the paper is coming along. There is now a community improving and learning from the system.

More #gastruloid studies. Benchmarking correlations between RNA/proteins w/ acquiring information @ phosphorylation across #mouse & #human www.biorxiv.org/content/10.1...
Also looking at #Disease modelling. Fantastic #TourDForce Valuable bench marking and insight
@dschweppe.bsky.social #SCBEMs

Further evidence that the #gastruloid system models the natural embryo from this spatiotemporal map of mouse #gastrulation
www.cell.com/cell-reports...
important as it provides a context for the, some times surprising, findings that the model is providing.

….and more #gastruloid preprint with proof of how to use their robustness and scalabiliy in high throughput screens to learn about #posttranscriptional regulation of gene expression @ Sendoel and Lutolf labs www.biorxiv.org/content/10.1...

In preprints: exploring developmental robustness and timing with gastruloids How developmental processes are coordinated in time and space to ensure the robust formation of complex, functional patterns during embryogenesis remains an outstanding question. Investigating this in...

Check out our "In Preprints" @dev-journal.bsky.social w/ Yonit Maroudas-Sacks & Marc Trani Bustos @mpi-cbg.de @poldresden.bsky.social, putting recent #gastruloid work from @viktri08.bsky.social @thomasgregor.bsky.social @amartinezarias.bsky.social labs in broader perspective: doi.org/10.1242/dev....

Fossil #gastruloid found in China.
I suspected the body plan they represent is old but....this old?

4 days left until the registration deadline for #BaCell3D 2025!

Click here to join us at the forefront of #organoids research:
conferences.unibas.ch/frontend/ind...

#embryoid #assembloid #tumoroid #NAMs #gastruloid #stemcells #tissueengineering #reduce #replace #refine #3Rs #3Dmodels #organonchip

4 days left until the registration deadline for #BaCell3D 2025!

Click here to join us at the forefront of #organoid research:
conferences.unibas.ch/frontend/ind...

#embryoid #assembloid #tumoroid #NAMs #gastruloid #stemcells #tissueengineering #reduce #replace #refine #3Rs #3Dmodels #organonchip

Identifying cross-lineage dependencies of cell-type-specific regulators in mouse gastruloids Correct gene expression levels are crucial for normal development. Advances in genomics enable the inference of gene regulatory programs active during…

And to finish a hat-trick of #gastruloid papers @bracciolilab.bsky.social on the influence of epigenetics on lineage decisions shorturl.at/aA6yy

A few reflections on the Barcelona @PRBB #gastruloid meeting
🧵

In the wake of Barcelona #Gastruloid meeting, we can say w/ some confidence that this is a system w/ potential in several areas of biomedical research: models, rather than replicas, are useful &also teach. For details
linkinghub.elsevier.com/retrieve/pii...
onlinelibrary.wiley.com/doi/10.1002/...

The Barcelona #gastruloid meeting has been a blast. A witness to a field that is maturing and a statement of a promise that lurks in its horizon. Thank you @joshifrenster.bsky.social @dias-andre.bsky.social and Ulla Fiuza for the organization, @EMBO, @ERC and the community for support.

January has been a plentiful month for #gastruloid #preprints. Here @thomasgregor.bsky.social @denisduboule.bsky.social & colleagues introduce a new family of #hydrogels and probe the effect of mechanical constrains on morphogenesis www.biorxiv.org/content/10.1...
#NotInTheGenes #InNumbersWeTrust

1/3 Embryogenesis requires fit cells. Here, following work from @miguel-torres-1963.bsky.social & @tristanrodriguez72.bsky.social and led by @joshifrenster.bsky.social we develop a #gastruloid model of #CellCompetition
www.biorxiv.org/content/10.1...
showing it recapitulates much of the embryo 🧵

It's #FluorescenceFriday again!

Some more #Xenopus... This time a #gastruloid formed by treating an explant of blastula presumptive ectoderm cells with Activin.

Nuclei labelled with H2B-mCherry with colour indicating size.

Let's get the discussion rolling with a starter pack that will grow over time!
go.bsky.app/JyvbmXA

#gastruloid #stembryo #gastruloids

Gastruloid meeting Barcelona 20-21.03.2025 Dear all, The lab of Alfonso Martinez Arias is organizing a gastruloid meeting at the Barcelona Biomedical Research Park (PRBB), in Barcelona (Spain), on March 20th-21st, 2025 (Thursday afternoon and...

🚨 The Gastruloid Meeting will take place in Barcelona, Spain on March 20-21st 2025. Registration will be free but mandatory. Please let us know if you plan on attending, using this link:
forms.gle/EtHZukwqgyN6...
(Pre-registration is closing soon)
Spread the word! #gastruloid #conference