Epigenetics Update - Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genes bit.ly/4bdXLmx

Srinivas Ramachandran & Xiaojun Ren in Mol Cell

#Epigenetics #PRC2 #Chromatin
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Hi-res insights without cell sorting; epigenometech.com

Epigenetics Update - Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains bit.ly/3NmLO5Q

Edwina McGlinn and Chen Davidovich (Monash University) reporting in Mol Cell

#Epigenetics #PRC2 #H3K27me3
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Perfect for cancer, immunology, and aging; epigenometech.com

Epigenetics Update - The conserved N-terminal SANT1-binding domain (SBD) of EZH2 regulates PRC2 activity bit.ly/460jVa1

Agata L. Patriotis (Rockefeller University) reporting in Genes Dev

#Epigenetics #EZH2 #PRC2
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Perfect for cancer, immunology, and aging research; epigenometech.com

Epigenetics Update - EZHIP restricts noncanonical PRC2 binding and regulates H3K27me3 intergenerational inheritance and reprogramming bit.ly/47obbub

#Epigenetic #Chromatin #H3K27me3 #PRC2 #IntergenerationalInheritance

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High-resolution insights without cell sorting; epigenometech.com

A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in Paramecium Abstract. To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms

Our latest paper on a histone methyltransferase-independent function of PRC2 controlling small RNA dynamics during programmed DNA elimination in Paramecium is now published in #NAR.
#RNAbiology #TEsky #smallRNAs #PRC2 #DNAelimination
1/5
academic.oup.com/nar/article-...

Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation Much et al. reveal that the PRC2 subcomplexes PRC2.1 and PRC2.2 play distinct roles in the epigenetic repression of developmental genes in human stem cells. Interactions between the PRC2 core and its ...

Epigenetics Update - Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation bit.ly/4lson6m

Yicheng Long (Weill Cornell Medicine) reporting in Mol Cell

#Epigenetics #PRC2 #H3K27me3
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High-resolution insights without cell sorting; epigenometech.com

Spoiler alert!
We found local nucleosome dynamics at the FLC locus in Arabidopsis 🌱 that:
(1) integrate a cold-induced silencing mechanism
(2) reveal H2A.Z incorporation preventing silencing by #PRC1 and #PRC2
(3) involve local/fine-scale 3D structural changes to the chromatin

Prof Daniel J Gibbs Daniel Gibbs is Professor of Molecular Plant Science, Plant Science and Food Security Theme Lead, Biosciences Deputy Head of Research, and UoB BBSRC Strategy Group Chair.

Daniel Gibbs is sharing their beautiful work on #N_degron pathway & #PRC2 (Polycomb repressive complex 2) www.birmingham.ac.uk/staff/profil... #plantproteolysis2025

#CancerResearch #Chromatin #EZH2 #PRC1 #PRC2 #Quiescence #EZH2Inhibitors

Starting the Regulation of Gene Expression session, Chen Davidovich talking about how #RNA binds a regulatory site to inhibit the histone methyltransferase #PRC2. PRC2's RNA binding regulatory center is exposed when bound with most of it's accessory subunits. #LorneGenome