Spoiler alert!
We found local nucleosome dynamics at the FLC locus in Arabidopsis 🌱 that:
(1) integrate a cold-induced silencing mechanism
(2) reveal H2A.Z incorporation preventing silencing by #PRC1 and #PRC2
(3) involve local/fine-scale 3D structural changes to the chromatin

How do different #PRC1 complexes contribute to the regulation of #NSC fate? Side-by-side comparison of canonical and non-canonical PRC1 in #proliferation and #differentiation.

Our study is now published:
www.life-science-alliance.org/content/8/4/...

By Janine Hoffmann @crtd-tud.bsky.social

#CancerResearch #Chromatin #EZH2 #PRC1 #PRC2 #Quiescence #EZH2Inhibitors