#publichealth #ecology #occupationalhealth #Alzheimers #CCR2 #CCR4 #gerontology #neurology #SDGs

Exhaust fumes,
cadmium,
and insufficient sunlight

cause chronically elevated CCL2 and TNF (TNF-α),
autoimmune diseases,
systemic inflammation,
neuroinflammation,
mental illness,
and neurodegeneration.

MARTRE family proteins negatively regulate CCR4-NOT activity to protect poly(A) tail length and promote translation of maternal mRNA - Nature Communications This study identifies a family of protein, MARTRE, as regulators of poly(A) tail length in early mouse embryos. MARTREs inhibit CCR4-NOT complex-mediated deadenylation, ensuring efficient translation ...

Interesting!

#MARTRE #CCR4 #NOT #PolyA #Tail #Polyadenylation #RNA #Translation

www.nature.com/articles/s41...