Species phylogeny, genomic and transcriptomic data, and Ne proxies used in the present study. Left: Phylogenetic tree of the 100 metazoan species considered. Middle: Available genome and transcriptome datasets of each species concerned, including CAGE-seq, 3′-end-seq, RNA-seq, coding genes, and BUSCO genes. Right: Ne and proxies.

What is the evolutionary significance of alternative #transcription initiation, #splicing & #polyadenylation? This study of 75 metazoan species suggests that most transcript diversity reflects deleterious RNA processing errors rather than adaptive function @plosbiology.org 🧪 plos.io/3Pcs2e6

Species phylogeny, genomic and transcriptomic data, and Ne proxies used in the present study. Left: Phylogenetic tree of the 100 metazoan species considered. Middle: Available genome and transcriptome datasets of each species concerned, including CAGE-seq, 3′-end-seq, RNA-seq, coding genes, and BUSCO genes. Right: Ne and proxies.

What is the evolutionary significance of alternative #transcription initiation, #splicing & #polyadenylation? This study of 75 metazoan species suggests that most transcript diversity reflects deleterious RNA processing errors rather than adaptive function @plosbiology.org 🧪 plos.io/3Pcs2e6

Species phylogeny, genomic and transcriptomic data, and Ne proxies used in the present study. Left: Phylogenetic tree of the 100 metazoan species considered. Middle: Available genome and transcriptome datasets of each species concerned, including CAGE-seq, 3′-end-seq, RNA-seq, coding genes, and BUSCO genes. Right: Ne and proxies.

What is the evolutionary significance of alternative #transcription initiation, #splicing & #polyadenylation? This study of 75 metazoan species suggests that most transcript diversity reflects deleterious RNA processing errors rather than adaptive function @plosbiology.org 🧪 plos.io/3Pcs2e6

⏪ G&D RECAP ⏪

🗓️ November 2025
RESEARCH PAPER: A kinetic ruler controls mRNA poly(A) tail length
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full

#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC

OUTLOOK: End of the line: a kinetic ruler model for poly(A) tail termination
By Anita Corbett
➡️ https://genesdev.cshlp.org/content/39/21-22/1267.full

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full

#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC

RESEARCH PAPER: A kinetic ruler controls mRNA poly(A) tail length
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full

#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC

#Regulation and #functions of alternative #polyadenylation in #fungi
doi.org/10.1080/2150...
@tandfresearch.bsky.social

Single-molecule multimodal timing of in vivo mRNA synthesis mRNA synthesis requires extensive pre-mRNA maturation, the organisation of which remains unclear. Here, we directly sequence pre-mRNA without metabolic labelling or amplification to resolve transcript...

"Single-molecule multimodal timing of in vivo mRNA synthesis" a collaboration with Rippei Hayashi's lab, work led by AJ Sethi #RNA #pre-mRNA #splicing #RNAprocessing #m6A #polyadenylation
www.biorxiv.org/content/10.1...

Nice! #TENT5A #SARSCoV2 #Polyadenylation #RNA

#Regulation and #functions of alternative #polyadenylation in #fungi
doi.org/10.1080/2150...
@tandfresearch.bsky.social

MARTRE family proteins negatively regulate CCR4-NOT activity to protect poly(A) tail length and promote translation of maternal mRNA - Nature Communications This study identifies a family of protein, MARTRE, as regulators of poly(A) tail length in early mouse embryos. MARTREs inhibit CCR4-NOT complex-mediated deadenylation, ensuring efficient translation ...

Interesting!

#MARTRE #CCR4 #NOT #PolyA #Tail #Polyadenylation #RNA #Translation

www.nature.com/articles/s41...