Nice! #TENT5A #SARSCoV2 #Polyadenylation #RNA
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Hashtag
#TENT5A
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Notably, this effect was specific to #mRNA vaccines - #TENT5A deficiency did not impair antibody production in response to the protein-based #vaccine #Nuvaxovid (@novavax.bsky.social). (16/n)
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🐭 In vivo studies showed that TENT5A-deficient mice produced significantly less antigen-specific #antibodies following #mRNA #vaccination. This highlights the essential role of #TENT5A in mounting an effective immune response to mRNA-based vaccines. (15/n)
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Our findings reveal a mechanistic principle: spatial proximity to ER-resident #TENT5A governs re-adenylation efficiency. This positions the #endoplasmic #reticulum as a central hub not only for #mRNA translation, but also for post-transcriptional regulation. (14/n)
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We found that #macrophages—not dendritic cells—are the primary cells that take up mRNA vaccine #LNPs and express #TENT5A, positioning them as key players in regulating mRNA stability via re-adenylation. (11/n)
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We identified #TENT5A -a polyA polymerase our lab has studied extensively - as responsible for this effect. Its expression is induced by vaccine delivery, most likely through innate immune signaling (please compare our previous paper: doi.org/10.1126/scia...).
#InnateImmunity(9/n)
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