Multiomics #MendelianRandomization links #SERPING1 to #COPD risk; higher levels associate with better #lungfunction and slower FEV₁ decline, while mouse overexpression improves lung health, supporting a complement-pathway biomarker and target.

#STTT: doi.org/10.1038/s413...

Researchers integrate #multiomics #MendelianRandomization and longitudinal cohorts to identify #SERPING1 as a causal #COPD modifier whose higher levels slow FEV₁ decline and improve #LungFunction in smoke-exposed mice.

#OpenAccess in #STTT: doi.org/10.1038/s413...