The LAV-BPIFB4 gene effectively counteracts #Cardiovascular decline in Hutchinson–Gilford progeria syndrome models by improving diastolic function and reducing #MyocardialFibrosis. @bristoluni.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

Dapagliflozin Suppressed Cuproptosis and Myocardial Fibrosis in Myocardial Infarction Through HIF-1α/TGF-β Pathway

This Current Medical Science shows that #Dapagliflozin improves heart function, alleviates #MyocardiaInjury and mitigates #MyocardialFibrosis by suppressing HIF-1α/TGF-β-mediated #Cuproptosis. #medsky
To read more, click here: doi.org/10.1007/s115...

#TET3 is a regulator and can be targeted for the intervention of #MyocardialFibrosis

By C. Zhu, W. Hong, Y. Zhu, D. Jiang, Y. Xu, M. Kong and colleagues at Nanjing Medical University

🗞️ doi.org/10.1038/s443...

cTnI193His-M mice increase glucose uptake and metabolism via the PI3K/AKT pathway to meet high energy demands during the early stages of diastolic dysfunction, resulting in the #pathogenesis of #MyocardialFibrosis and #HeartFailure. #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...

Frontiers | Possible mechanisms of SARS-CoV-2-associated myocardial fibrosis: reflections in the post-pandemic era Since December 2019, coronavirus disease 2019 (COVID-19) has been spreading worldwide with devastating immediate or long-term effects on people’s health. Alt...

Overview the underlying molecular mechanisms of #COVID19 -associated #myocardialfibrosis.

www.frontiersin.org/journals/mic...