BMP9 induces osteogenic differentiation through up-regulating LGR4 via the mTORC1/Stat3 pathway in mesenchymal stem cells

LGR4 enhances #BMP9-induced #osteogenesis in #MesenchymalStemCells via mTORC1/Stat3 signaling, promoting bone formation while its inhibition shifts differentiation toward #adipogenesis, highlighting LGR4 as a key target in #BoneTissueEngineering.

#OpenAccess: doi.org/10.1016/j.ge...

#SIRT5 boosts #BMP9‑induced #osteogenesis by stabilizing #HIF1α via reduced acetylation/malonylation, elevating osteogenic markers and enhancing #BoneRegeneration, offering a novel strategy for improved #BoneTissueEngineering outcomes.
#OpenAccess: doi.org/10.1016/j.ge...

Inspired by LEGO® bricks, this #IJEM study developed innovative modular scaffolds, based on machine vision for rapid & intelligent assembly according to #BoneDefects, highlighting their potential in #BoneTissueEngineering.

#OpenAccess: doi.org/10.1088/2631...

Coiled PCL fibrous bundles fabricated using an alginate-based composite system & #3DPrinting, demonstrate enhanced mechanotransduction & upregulation of #Osteogenic-genes in hASCs, highlighting its potential in #BoneTissueEngineering.

#IJEM #OpenAccess: doi.org/10.1088/2631...

Leaving the office having just pressed the button on our next big grant application today! Keep everything crossed! 🤞🏻 🤞🏻 🤞🏻 #bonetissueengineering #bone #tissueengineering