#EPI
m6A demethylation steers pig fat-cell fate, switching metabolic genes off while co-opting cancer pathways. Adipogenesis meets oncogenic echoes. 🐷🧬
Details: www.maxapress.com/article/doi/10.48130/epi...
#adipogenesis #epigenetics
Xenoestrogens like BPA don’t just disrupt hormones they promote adipogenesis, increasing fat cell formation and overall fat mass.
#EDCs #Adipogenesis #HormoneDisruption #BPA #HealthAwareness
A comprehensive review of how lipid metabolism shapes osteoporosis, from clinical implications to cellular mechanisms.
#LipidMetabolism #Osteoporosis #BoneMetabolism #Adipogenesis #BoneHealth #MetabolicDisease
www.sciencedirect.com/science/arti...
Piezo1 suppresses bone marrow #Adipogenesis by inhibiting the c-Jun-Ccl2-NF-κB-Lcn2 inflammatory autocrine loop via CaMKII/Klf2, providing insights into the link between #Mechanotransduction, #Inflammation, and cell fate determination. #MedSky
#OpenAccess: doi.org/10.1038/s413...
#Research
#Pharmacological inhibition of Ubiquitin-Specific Peptidase 10 (#USP10) with spautin-1 attenuates adipogenesis through CCAAT/Enhancer-Binding Protein Beta (C/EBPβ) destabilization doi.org/10.1186/s435...
#Spautin_1 #Adipogenesis #LipidAccumulation #Deubiquitination
RESEARCH COMMUNICATION: Igf2 regulates early postnatal DPP4+ preadipocyte pool expansion
By Altun et. al and Siegfried Ussar
➡️ https://genesdev.cshlp.org/content/39/23-24/1414.full
#adipose #stemcells #adipogenesis #insulinsignaling #celldifferentiation #IGF
New study with #JHU! Single-cell Raman imaging 🔬 shows fructose impairs brown adipocyte differentiation 🧬, leading to higher lipid unsaturation + esterification and stalled maturation. Glucose drives healthier BAT development. ⚡️
#RamanImaging #Adipogenesis #Metabolism #Fructose #BAT #SingleCell
#Cilia and #Centrosome friends- tomorrow is the big day!! 🎉 🎉
Organoids for #PCD, #CryoET of the base of motile cilia, TZ organization in #IRDs, macrophages & cystic niches in #PKD, how pro-inflammatory lipids & #adipogenesis AND cilia as signal-sending organelles shedding #EVs! 🤩 😍 Join us!!
The #mechanosensitive channel #Piezo1 in #BMMSCs suppresses #BoneMarrow #adipogenesis and promotes #BoneFormation by blocking the Ccl2–Lcn2 inflammatory loop, linking #mechanotransduction to #inflammation control and bone strength.
#OpenAccess in #STTT: doi.org/10.1038/s413...
This #TopicalReview by Elisa Villalobos et al. discusses understanding #adipogenesis in muscle degeneration for disease modulation, from fibro/adipogenic progenitors to adipocytes 📖 🔬
🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔆 #PaperSpotlight:
A new #research paper was #published on August 27, titled “Deregulated miR-145 and miR-27b in Hutchinson-Gilford progeria syndrome: implications for adipogenesis.”
🔗 doi.org/10.18632/agi...
#aging #quote #progeria #HGPS #adipogenesis #openaccess #journal #publishing #meded
🎥 #AgingShort:
Abstract #video about the #research paper, titled "Deregulated miR-145 and miR-27b in Hutchinson-Gilford progeria syndrome: implications for adipogenesis.” @tum.de
🔗 doi.org/10.18632/agi...
#aging #PaperSpotlight #progeria #adipogenesis #openaccess #journal #publishing
💪 New porcine intramuscular #adipocyte #cell model developed! Shows robust #fat accumulation and gene expression, helping us study lipid #metabolism and metabolic syndrome risk 🧬 #Adipogenesis #MetabolicResearch
If you are interested in 🧫 #fibroadipogenicpogenitors or #FAPs and #Adipogenesis please check our review 😱🥳👇🏽 Here we provide a summary of the emerging role of #FAPs in Neurmuscular🦵🏻and Cardiovascular diseases🫀 #NMDs #CVDs Enjoy the reading!!
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Epigenetics Update - IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells go.nature.com/45s8wyx
#Epigenetics #IRX3 #Adipogenesis
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Perfect for cancer, immunology, and aging research; epigenometech.com
IRX3 buffers the SUMOylation to promote adipogenesis and block osteogenesis. IRX3 loss boosts SUMOylation, inhibits PPARγ, and pushes cells toward bone fate, which is reversible with SUMOylation inhibition.
IRX3 is an epigenetic gatekeeper.
#Epigenetics #Adipogenesis #ObesityRisk #SUMOylation
@mark-christian-lab.bsky.social @jhobbs22.bsky.social #acadmicposters #adipogenesis #adiposeresearch #conference
An honour to present our research on miRNA regulation during #BrownFat development and #browning of #WhiteFat at #SHiMR2025 symposium. Grateful for the opportunity and inspiring science all around! #adipogenesis #SHIMR_NTU #NTU_Metabolic @mark-christian-lab.bsky.social @jhobbs22.bsky.social
🧬 Dr @nkalender.bsky.social on the regulatory role of miRNAs in #AdiposeTissue plasticity. #adipogenesis #SHIMR_NTU #NTU_Metabolic @mark-christian-lab.bsky.social
🐟 We then exposed #Zebrafish embryos to PE leachates and found changes in mRNA expression (behavior was not impacted).
🧬Affected genes are involved in #adipogenesis, lipid metabolism, and endocrine regulation. #EDC
In a pivotal study published in Bone Research in April 2025, researchers explored the role of KIAA1199, a protein secreted by bone marrow cells, in regulating fat tissue formation and energy metabolism.
#Bone #adipogenesis
Details: doi.org/10.1038/s414...
Speaker Spotlight: Dr. Rana Gupta @duke-university.bsky.social
Join us @ #AdiposeBiology Conference in Montreal🇨🇦, Aug 19-20, 2025, to hear from Rana about #adiposedevelopment. Don’t miss his talk!
🔗 Register now – adiposebiology.com
#ABC2025 #Metabolism #Adipogenesis #ObesityResearch
As TAK-981 is in clinical trial for cancer, these findings highlight the need to consider its potential metabolic effects.
Nice collaboration between my group at @uio.no @biovitenskap.bsky.social, Antoine Martinez @ucauvergne.bsky.social
#Adipogenesis #SUMOylation #Metabolism #InVivo #CancerTherapy
PDZRN3 (E3 ligase) suppresses #Adipogenesis of Sca1+🐭#SkeletalMuscle mesenchymal progenitors (PDGFRα+TCF4+) via⏬Wnt/β-Catenin
Pdgfra-CreER::Pdzrn3 KO🐭▶️
⏫Denervation-induced intramuscular #Adipogenesis #IMAT
⏬muscle mass
Regen Ther 2025
www.sciencedirect.com/science/arti...
Excited to share our latest findings on how nutrients affect stem cell behavior! Replacing glucose with fructose induces stress and fails to induce adipocyte differentiation. Instead, it prompts release of senescence-associated cytokines. #StemCells #Metabolism #Adipogenesis #Cytokines
Mark Lee's acknowledgement slide with his team, advisors and funding support.
We end with a bang on #CiliarySignaling GPCRs regulating #MetabolicFate for #preadipocytes- how inflammatory cytokine #PGE2, elevated in #obesity, through EP4 determines #adipogenesis through unexpected second signals to control #actin Mark Lee (Hilgendorf lab) closes on a high! #ukcilia2025 /5
Are we ready for the next wegovy? At the #AsilomarChromatin conference and riveted by #TapasKumarKundu #JNCASR presentation on #MASH (formerly #NASH), #histone butyrylation, #adipogenesis, and LTK-14A a small molecule #p300-inhibitor. #obesity
#Imidacloprid, a #neonicotinoid insecticide, potentiates #adipogenesis in 3T3-L1 adipocytes [J Agric Food Chem. 2013] http://www.ncbi.nlm.nih.gov/pubmed/23215241
