Piezoelectric electrospun scaffold incorporating ibuprofen loaded ultrasound-responsive mesoporous silica nanoparticles for tissue regeneration Inflammation plays a pivotal role in tissue repair, and its modulation is crucial to avoid excessive immune activation or suppression. Three-dimensional scaffolds that can control the release of anti-...

⚡ Ultrasound-activated smart scaffolds? A new study shows an electric signal–producing scaffold that releases #ibuprofen when hit with #ultrasound. Using our #PGE2 kit(K051-H), researchers saw rapid shifts in #cell behavior. Which response changed most?📷https://bit.ly/44o12gl
#Research #cellbiology

¿Cómo han logrado regenerar el cartílago en la artrosis? Bloquear 15-PGDH regenera cartílago en artrosis; claves del estudio de Stanford, riesgos, plazos e impacto clínico en tratamiento en España. Un equipo de Stanford Medicine ha descrito una vía biológic...

¿Cómo han logrado regenerar el cartílago en la artrosis? #Artrosis #Regeneración #Cartílago #15PGDH #PGE2 #Osteoartritis #StanfordMedicine #Ciencia #EnsayosClínicos #Salud #España #MedicinaDePrecisión #Sarcopenia #9dediciembre #felizmartes
donporque.com/han-logrado-...

The Reduction in the Mitochondrial Membrane Potential in Aging: The Role of the Mitochondrial Permeability Transition Pore It is widely reported that the mitochondrial membrane potential, ∆Ψm, is reduced in aging animals. It was recently suggested that the lower ∆Ψm in aged animals modulates mitochondrial bioenergetics an...

"Activation of the voltage-gated mPTP depolarizes the mitochondria, inhibits oxidative phosphorylation, releases large amounts of calcium and mROS, and depletes cellular NAD+, thus accelerating degenerative diseases and aging." pmc.ncbi.nlm.nih.gov/articles/PMC... #aging #mitocondria #PGE2 (?)

"Our work reveals a previously unappreciated ability of #PGE2 to regulate mitochondrial membrane potential and a mitochondrial membrane potential-based mechanism through which mitochondria are able to regulate nuclear gene expression."(126 voltage-regulated genes) www.cell.com/immunity/pdf... #aging

This common molecule reverses muscle ageing and prevents frailty, scientists find Single dose of treatment could be sufficient to restore muscle function, researchers say

“PGE2 is an alarm clock to wake up the stem cells and repair the damage. Aging essentially reduces the volume of the alarm and the stem cells have also put on ear plugs,” said study author Yu Xin Wang. www.independent.co.uk/news/science... #aging #PGE2 #sarcopenia

Mark Lee's acknowledgement slide with his team, advisors and funding support.

We end with a bang on #CiliarySignaling GPCRs regulating #MetabolicFate for #preadipocytes- how inflammatory cytokine #PGE2, elevated in #obesity, through EP4 determines #adipogenesis through unexpected second signals to control #actin Mark Lee (Hilgendorf lab) closes on a high! #ukcilia2025 /5