BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series

And we’ll be back for four sessions in 2026- first 14/01/2026! Register: www.eventbrite.co.uk/e/bscb-genso...
#UKCilia2025 /9

We finished with our panel discussion with some very #HotTakes revisited and directions of travel for the field debated … #UKCilia2025 /8

We finish #MetabolicDisease- cilia on preadipocytes controlling 2 competing ciliary signaling cascades to differentiate or proliferate via FFAR4 or PGE2/EP4, via ROCK2 on actin stress fibers to grow lipid droplets. Wowed by @guacamarklee.bsky.social from the Hilgendorf lab! #UKCilia2025 /7

Alexis Semmel from Jessica Tanis lab wows us with how distinct ciliary #EV contents are released from either the cilia base or tip by local phosphoinositide codes in worms without affecting cilia length or presence. How is the cadence of release set? #UKCilia2025 /6

We go big picture to see how ciliary dysfunction can regulate tissue niche remodelling and cystic disease progression in kidney via macrophage reprogramming in #ADPKD with Rudi Karl from @wachtenlab.bsky.social. #UKCilia2025 /5

No momentum lost as we dazzled with the ciliary necklace, CEP290 and transition zone integrity in #photoreceptors, inner scaffold maintenance & membrane attachment key for gating with the amazing @abimoye.bsky.social (Wensel group and current @carlorivolta.bsky.social ). #IRDs #UKCilia2025 /4

Next up @computingcaitie.bsky.social from @cellarchlab.com marvels us with in situ structural biology of mammalian motile cilia base- power of #cryoET with #XL-MS & #UExM! Stunning cataloguing of MIPs in different axial positions & cilia types, filamentous actin in action. #UKCilia2025 /3

A superbly synchronized talk from Joy Zheng & Yan Li, from Mu He's lab, Hong Kong Univeristy on airway epithelial-mesenchymal organoids from #hIPSCs for modelling syndromic #ciliopathies. More mature lineages in a dish. Fascinating work on TZ components and motile cilia function. #UKCilia2025 /2

Our 53rd BSCB GenSoc UK Cilia Network e-symposium: JCS Special Issue on Cilia and Flagella was a smash hit! A staggering 🤩 435 participants 🤩 for outstanding and sometimes contentious takes on fantastic #cilia & #centrosome research. From 🇨🇱 Chile to 🇨🇳 China to the 🇨🇿 Czech Republic- #UKCilia2025 /1

We wrap-up with our deep-dive panel discussion. #FanFavorite #UKCilia2025 /7

We have a fabulous finish with @konjikusicmia.bsky.social (@reiterlab.bsky.social, UCSF) on #GPCRs, #signaling, and #hypogonadism in #BBS models across the hypothalamus-pituitary-gonad axes and its many ciliated cell types! #Ciliopathies? www.biorxiv.org/content/10.1... #UKCilia2025 /6

What do #DNADamageRepair, #CentrioleBiogenesis and #R-loops have in common- required for multiciliogenesis, where DNA damage scales with number of forming #centrioles! Masterclass talk Cayla Jewett (Pearson lab, Anschutz, UColorado). www.biorxiv.org/content/10.1... #UKCilia2025 /5

CSF-flow and ependymal cilia in #MultipleSclerosis pathophysiology (ventricular enlargement & decreased flow) in human & mouse models of disease- intriguing talk by Maxime Bigotte (Stratton lab, McGill) from his recently pre-printed work www.biorxiv.org/content/10.1... #UKCilia2025 /4

Soon to be #NewPI Yinwen Liang (Joyner lab, MSKCC) on informatics approach to find novel transcriptional regulators of #ciliogenesis- SP5 and SP8 specificity protein TFs drive expression of core ciliary machinery in primary & motile cilia! www.biorxiv.org/content/10.1... #UKCilia2025 /3

Next new Dr Poulomi Das (Lechtreck lab UGA) marvels with mysterious mastigonemes in Chlamy and subcomplexes involved in targeting PKD2 channels to ciliary subdomains. 🧪 #UKCilia2025 /2

Our 52nd BSCB GenSoc UK Cilia and Centrosome e-symposium kicks off with a spectacular #super-resolution showcase on how RPGR variants affect #multiciliogenesis & cilia motility to cause #PCD or #IRDs via #actin dynamics! Zhen Liu wows- ICYMI: www.biorxiv.org/content/10.1... #UKCilia2025 /1

A great panel discussion followed with many questions for our panellists... #UKCilia2025 6/7

We close: a fan fave PTM #ubiquitin- roles in ciliary cargo retrieval by #IFT machinery as it remodels at the #cilia/ #flagellar tip, open questions re dynamics across time & space- preprint to drop soon... Amazing @sven-m-lange.bsky.social (@alanbrownhms.bsky.social lab, Harvard) #UKCilia2025 5/7

More on #cilia, #flagella & #fertility with Alyssa Long (@tamaragenes.bsky.social lab, Emory, US) on dissecting cilial vs non-cilial functions for ARL13B in rescuing #mouse mutant #ciliopathy phenotypes in vivo- great questions & discussions live! ICYMI: doi.org/10.1101/2025... #UKCilia2025 4/7

We move to magnificent #meiosis #ChromosomalBouquet & #zygotene cilia with Avishag Mytlis (@yanivelkouby.bsky.social lab, Hebrew University, IL) on unpublished work for countering mechanical forces allowing telomere rotation & clustering. Role in human infertility- #ciliopathies? #UKCilia2025 3/7

Next rockstar talk from Karthika Balasubramaniam (Cynthia He, NUS, SG) on curious roles of PIH homologs in regulation of axonemal #dynein assembly in #Trypanosomes- #DynAPs, chaperoning, (co-)translation, folding in right time & space?! See: www.molbiolcell.org/doi/10.1091/... #ukcilia2025 2/7

What a spectacular 🧪 session today- for our 51st @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposia with Yi Zhang (Junmin Pan lab, Tsinghua U) on conserved RCK kinase relays regulating axonemal #microtubule stability during #CiliaAssembly! #ukcilia2025 1/7

BSCB GenSoc UK Cilia Network e-Symposia Series BSCB GenSoc UK Cilia Network e-Symposia Series

We will be back 22/04/2025 51st @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium- volunteer to speak here: forms.gle/jt7MenwJ4hN9... OR sign up for the series here: www.eventbrite.co.uk/e/bscb-genso... #UKcilia2025 /fin

Intriguing panel discussion on how concentric hierarchies are established in extended photoreceptor #ConnectingCilia & how dense structure allows #trafficking, how #autism proteins in chromatin and synapse #moolight at cilia, how ciliary B cell SSTR3 allows for signaling and more... #ukcilia2025 /6

Mark Lee's acknowledgement slide with his team, advisors and funding support.

We end with a bang on #CiliarySignaling GPCRs regulating #MetabolicFate for #preadipocytes- how inflammatory cytokine #PGE2, elevated in #obesity, through EP4 determines #adipogenesis through unexpected second signals to control #actin Mark Lee (Hilgendorf lab) closes on a high! #ukcilia2025 /5

Matthew's acknowledgement slide with teams from Chen and Hofer labs, and their funders.

In keeping with #cilia and #NeuronalFunction, Matthew Strobel (Chen/Hofer labs) on how deleting IFT88 postnatally in brains impairs normal #sleep patterns, EEG activity & brainwave power, with loss of synchronisation & impaired #memory! Hot off the press: doi.org/10.1038/s415... #ukcilia2025 /4

Acknowledgement slide for Elina Kostyanovskaya from Willsey lab on her team, collaborators, patients and patient groups and funders.

Power of #HumanGenetics- is #autism a #ciliopathy? @elinakosty.bsky.social (goodfrognosis.bsky.social) makes a compelling case for unexpected synaptic & chromatin disease genes at #cilia, both #primary & #motile-"cilia are beautiful in #Xenopus". ICYMI: doi.org/10.1101/2024... #ukcilia2025 /3

Acknowledgement slide for Ceren Incedal's talk with lab members and collaborators, and code to preprint with picture of islet ciliated beta cells and proximity to delta cells.

Next up PhD student Ceren Incedal (Ideal-Hagren lab) regales with how local somatostatin secreted from islet delta cells stimulates beta cell ciliary signaling via GLI2 in beautiful pre-print work. Fascinating ciliary synapses! #T2D #cilialength doi: doi.org/10.1101/2024... #UKCilia2025 /2

Acknowledgement slide of Olivier Mercey's lab, collaborators and funders showing ultra expansion microscopy images of mouse photoreceptor connecting cilia.

Our 50th @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium kicked off with #UExM masterclass! Mysteries & hierarchies of #tubulin #PTMs in #ConnectingCilium #Bulge #IRDs- Olivier Mercey @centriolelab.bsky.social www.embopress.org/doi/full/10.... #ukcilia2025 /1