Celebrating our PhD Graduates - Sandip Patra from Dr. Rupinder Kaur's Lab. His thesis work helps understand the underlying mechanisms of CgYapsins-mediated DNA damage tolerance mechanisms in Human pathogenic fungi.
#candidaglabrata #GPI-linkedaspartylproteases #DNAdamagerepair #genotoxic #phdthesis
The first high-resolution structure of the folded domains of Xrs2 from S. cerevisiae will advance understanding of its functions in the DNA damage response and telomere-length maintenance @UMNews #Nbs1Xrs2 #DNADoubleStrandBreaks #DNADamageRepair doi.org/10.1107/S205...
A novel ENPP1+ phenotype confers radioresistance by enhancing #DNADamageRepair (DDR), while its inhibition impairs DDR, thereby enhancing #Radiosensitivity and antitumor immune responses in #TNBC. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
A novel ENPP1+ phenotype confers radioresistance by enhancing #DNADamageRepair (DDR), while its inhibition impairs DDR, thereby enhancing #Radiosensitivity and antitumor immune responses in #TNBC. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
Data-driven dynamic modelling identifies polyploidisation as key process in cell cycle progression upon DNA damage
Beltman, J. B., Bouwman, P. et al.
Paper
Details
#DataDrivenModeling #CellCycleProgression #DNADamageRepair
What do #DNADamageRepair, #CentrioleBiogenesis and #R-loops have in common- required for multiciliogenesis, where DNA damage scales with number of forming #centrioles! Masterclass talk Cayla Jewett (Pearson lab, Anschutz, UColorado). www.biorxiv.org/content/10.1... #UKCilia2025 /5
Stucki and colleague @show how MDC1 recruits E3 ligases to repair DNA breaks 🧬🔬 #GenomeStability #DNADamageRepair
bioRxiv doi.org/10.1101/2024.07.20.60439
To cleave or not and how? The DNA exonucleases and endonucleases in immunity
This review provides a comprehensive overview on the functions of different exonucleases & #endonucleases, & highlights their roles in #DNADamageRepair, maintaining genome integrity, & regulating the innate immune cGAS-STING pathway. #medsky
#OpenAccess : https://buff.ly/3PTPOZt
